860478 | cis-4-methylsphingosine

cis-4-methylsphingosine


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cis-4-methylsphingosine

cis-4-methylsphingosine

cis-4-methylsphingosine

cis-4-methylsphingosine (cis-4M-Sph) is a synthetic sphingosine analogue that is readily taken up by cells and interacts with S1P receptors through its metabolite cis-4M-S1P in a manner similar to FTY720. cis-4M-Sph interacts primarily with the S1P receptors S1P(2) and S1P(3), and only weakly with S1P(1). cis-4M-Sph induces apoptosis of neuroblastoma cells.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C19H39NO2
Percent Composition
C 72.79%, H 12.54%, N 4.47%, O 10.21%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
1407154-31-7
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
313.518
Exact Mass
313.298
Synonyms
<p>cis-4M-Sph</p>
Ter Braak, M., R.F. Claas, B. Hegen, S. Labocha, N. Ferreiros, J. Pfeilschifter, A. Huwiler, G. van Echten-Deckert, and D. Meyer Zu Heringdorf. (2011). Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator. Biochem Pharmacol 81:617-25. [PubMed] van Echten-Deckert, G., A. Zschoche, T. Bar, R.R. Schmidt, A. Raths, T. Heinemann, and K. Sandhoff. (1997). cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons. J Biol Chem 272:15825-33. [PubMed]