cis-4-methylsphingosine | 860478
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- cis-4-methylsphingosine (cis-4M-Sph) is a synthetic sphingosine analogue that is readily taken up by cells and interacts with S1P receptors through its metabolite cis-4M-S1P in a manner similar to FTY720. cis-4M-Sph interacts primarily with the S1P receptors S1P(2) and S1P(3), and only weakly with S1P(1). cis-4M-Sph induces apoptosis of neuroblastoma cells.
- Molecular Formula
- Percent Composition
- C 72.79%, H 12.54%, N 4.47%, O 10.21%
- 1 Years
- CAS Number
CAS Registry Number is a Registered Trademark of the American Chemical Society
- Molecular Weight
- Exact Mass
van Echten-Deckert, G., A. Zschoche, T. Bar, R.R. Schmidt, A. Raths, T. Heinemann, and K. Sandhoff. (1997). cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons. J Biol Chem 272:15825-33. [PubMed]