860473 | 1-desoxymethylsphinganine

1-desoxymethylsphinganine (m17:0)


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1-desoxymethylsphinganine

1-desoxymethylsphinganine

1-desoxymethylsphinganine (m17:0)

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C17H37NO
Percent Composition
C 75.21%, H 13.74%, N 5.16%, O 5.89%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
1219484-98-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
271.482
Exact Mass
271.288
Synonyms
1-deoxymethylsphinganine(2R)-1-amino-2-hydroxy-heptadecane1-deoxy
Me SA1-desoxy
MeSa
110896

Wu J, Ma S, Sandhoff R, Ming Y, Hotz-Wagenblatt A, Timmerman V, Bonello-Palot N, Schlotter-Weigel B, Auer-Grumbach M, Seeman P, Löscher WN, Reindl M, Weiss F, Mah E, Weisshaar N, Madi A, Mohr K, Schlimbach T, Velasco Cárdenas RM, Koeppel J, Grünschläger F, Müller L, Baumeister M, Brügger B, Schmitt M, Wabnitz G, Samstag Y, Cui G. Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness. Immunity. 2019 Mar 23. pii: S1074-7613(19)30095-0. doi: 10.1016/j.immuni.2019.03.005. [Epub ahead of print]

PubMed ID: 30952607

Jimenez-Rojo, N., J. Sot, J.V. Busto, W.A. Shaw, J. Duan, A.H. Merrill Jr, A. Alonso, and F.M. Goni. (2014). Biophysical Properties of Novel 1-Deoxy-(Dihydro)ceramides Occurring in Mammalian Cells. Biophys J 107:2850-9. [PubMed]

PubMed ID: 25517151

Penno, A., M.M. Reilly, H. Houlden, M. Laura, K. Rentsch, V. Niederkofler, E.T. Stoeckli, G. Nicholson, F. Eichler, R.H. Brown Jr, A. von Eckardstein, and T. Hornemann. (2010). Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids. J Biol Chem 285:11178-87. [PubMed]

PubMed ID: 20097765

Pruett, S.T., A. Bushnev, K. Hagedorn, M. Adiga, C.A. Haynes, M.C. Sullards, D.C. Liotta, and A.H. Merrill Jr. (2008). Thematic Review Series: Sphingolipids. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. J Lipid Res 49:1621-39. [PubMed]

PubMed ID: 18499644

Zitomer, N.C., T. Mitchell, K.A. Voss, G.S. Bondy, S.T. Pruett, E.C. Garnier-Amblard, L.S. Liebeskind, H. Park, E. Wang, M.C. Sullards, A.H. Merrill Jr, and R.T. Riley. (2009). Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals.[Abstract]

PubMed ID: 19095642