860463 | N-C16-desoxymethylsphinganine

N-palmitoyl-1-desoxymethylsphinganine (m17:0/16:0)


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N-C16-desoxymethylsphinganine

N-C16-desoxymethylsphinganine

N-palmitoyl-1-desoxymethylsphinganine (m17:0/16:0)

Commonly referred to as 1-desoxymethyldihydroceramide (1-desoxyMeDHCer), this product is the N-acylated form of 1-desoxymethylsphinganine, a potent inhibitor of sphingolipid metabolism. The biological activity of 1-desoxyMeDHCer is not clearly understood at this time.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C33H67NO2
Percent Composition
C 77.73%, H 13.24%, N 2.75%, O 6.28%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
1246298-42-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
509.891
Exact Mass
509.517
Synonyms
<p>N-hexadecanoyl-1-desoxymethylsphinganine (m17:0/16:0)N-C16-1-desoxyMeDHCer110961</p>
Jimenez-Rojo, N., J. Sot, J.V. Busto, W.A. Shaw, J. Duan, A.H. Merrill Jr, A. Alonso, and F.M. Goni. (2014). Biophysical Properties of Novel 1-Deoxy-(Dihydro)ceramides Occurring in Mammalian Cells. Biophys J 107:2850-9. [PubMed] Pruett, S.T., A. Bushnev, K. Hagedorn, M. Adiga, C.A. Haynes, M.C. Sullards, D.C. Liotta, and A.H. Merrill Jr. (2008). Thematic Review Series: Sphingolipids. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. J Lipid Res 49:1621-39. [PubMed] Zitomer, N.C., T. Mitchell, K.A. Voss, G.S. Bondy, S.T. Pruett, E.C. Garnier-Amblard, L.S. Liebeskind, H. Park, E. Wang, M.C. Sullards, A.H. Merrill Jr, and R.T. Riley. (2009). Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals.[Abstract]