860463 | N-C16-desoxymethylsphinganine

N-palmitoyl-1-desoxymethylsphinganine (m17:0/16:0)


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N-C16-desoxymethylsphinganine

N-C16-desoxymethylsphinganine

N-palmitoyl-1-desoxymethylsphinganine (m17:0/16:0)

Commonly referred to as 1-desoxymethyldihydroceramide (1-desoxyMeDHCer), this product is the N-acylated form of 1-desoxymethylsphinganine, a potent inhibitor of sphingolipid metabolism. The biological activity of 1-desoxyMeDHCer is not clearly understood at this time.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C33H67NO2
Percent Composition
C 77.73%, H 13.24%, N 2.75%, O 6.28%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
1246298-42-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
509.891
Exact Mass
509.517
Synonyms
<p>N-hexadecanoyl-1-desoxymethylsphinganine (m17:0/16:0)N-C16-1-desoxyMeDHCer110961</p>

Jiménez-Rojo N, Sot J, Busto JV, Shaw WA, Duan J, Merrill AH Jr, Alonso A, Goñi FM. Biophysical properties of novel 1-deoxy-(dihydro)ceramides occurring in mammalian cells. Biophys J. 2014 Dec 16;107(12):2850-2859. doi: 10.1016/j.bpj.2014.10.010. PMID: 25517151; PMCID: PMC4269796.

PubMed ID: 25517151

Pruett ST, Bushnev A, Hagedorn K, Adiga M, Haynes CA, Sullards MC, Liotta DC, Merrill AH Jr. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. J Lipid Res. 2008 Aug;49(8):1621-39. doi: 10.1194/jlr.R800012-JLR200. Epub 2008 May 21. PMID: 18499644; PMCID: PMC2444003.

PubMed ID: 18499644

Zitomer NC, Mitchell T, Voss KA, Bondy GS, Pruett ST, Garnier-Amblard EC, Liebeskind LS, Park H, Wang E, Sullards MC, Merrill AH Jr, Riley RT. Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals. J Biol Chem. 2009 Feb 20;284(8):4786-95. doi: 10.1074/jbc.M808798200. Epub 2008 Dec 18. PMID: 19095642; PMCID: PMC2643501.

PubMed ID: 19095642