860462 | N-C16-deoxysphinganine

N-palmitoyl-1-deoxysphinganine (m18:0/16:0)


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N-C16-deoxysphinganine

N-C16-deoxysphinganine

N-palmitoyl-1-deoxysphinganine (m18:0/16:0)

Commonly referred to as 1-deoxydihydroceramide (1-deoxyDHCer), this product is the N-acylated form of 1-deoxysphinganine, a potent inhibitor of sphingolipid metabolism. The biological activity of 1-deoxyDHCer is not clearly understood at this time.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C34H69NO2
Percent Composition
C 77.94%, H 13.27%, N 2.67%, O 6.11%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
378755-69-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
523.917
Exact Mass
523.533
Synonyms
N-hexadecanoyl-1-deoxysphinganine (m18:0/16:0)
N-C16-1-deoxy
DHCer
110960

Jiménez-Rojo N, Sot J, Busto JV, Shaw WA, Duan J, Merrill AH Jr, Alonso A, Goñi FM. Biophysical properties of novel 1-deoxy-(dihydro)ceramides occurring in mammalian cells. Biophys J. 2014 Dec 16;107(12):2850-2859. doi: 10.1016/j.bpj.2014.10.010. PMID: 25517151; PMCID: PMC4269796.

PubMed ID: 25517151

Pruett ST, Bushnev A, Hagedorn K, Adiga M, Haynes CA, Sullards MC, Liotta DC, Merrill AH Jr. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. J Lipid Res. 2008 Aug;49(8):1621-39. doi: 10.1194/jlr.R800012-JLR200. Epub 2008 May 21. PMID: 18499644; PMCID: PMC2444003.

PubMed ID: 18499644

Zitomer NC, Mitchell T, Voss KA, Bondy GS, Pruett ST, Garnier-Amblard EC, Liebeskind LS, Park H, Wang E, Sullards MC, Merrill AH Jr, Riley RT. Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals. J Biol Chem. 2009 Feb 20;284(8):4786-95. doi: 10.1074/jbc.M808798200. Epub 2008 Dec 18. PMID: 19095642; PMCID: PMC2643501.

PubMed ID: 19095642