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C6-Pyridinium-Ceramide | 857450

D-erythro-2-N-[6'-(1"-pyridinium)-hexanoyl]-sphingosine bromide

857450P

Powder

857450P-
1 mg
$210.00
857450P-
5 mg
$840.00
857450P-
10 mg
$1470.00

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  • Data
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Molecular Formula
C29H51N2O3Br
Percent Composition
C 62.69%, H 9.25%, Br 14.38%, N 5.04%, O 8.64%
Purity
>99%
Stability
1 Year
Storage
-20°C
CAS Number
853992-70-8
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
555.631
Exact Mass
554.308
Synonyms
D-erythro-C6-pyridinium-ceramide
LCL29
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Notes
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File. 
Separovic, D., Bielawski, J., Pierce, J.S., Merchant, S., Tarca, A.L., Ogretmen, B., Korbelik, M. (2009). Increased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas. Br J Cancer. 100:626-32. [PubMed]Szulc, Z.M., Bielawski, J., Gracz, H., Gustilo, M., Mayroo, N., Hannun, Y.A., Obeid, L.M., Bielawska A. (2006). Tailoring structure-function and targeting properties of ceramides by site-specific cationization. Bioorg Med Chem. 14:7083-104. [PubMed]Novgorodov, S.A., Szulc, Z.M., Luberto, C., Jones, J.A., Bielawski, J., Bielawska, A., Hannun, Y.A., Obeid, L.M. (2005). Positively charged ceramide is a potent inducer of mitochondrial permeabilization. J Biol Chem 280:16096-105. [PubMed]Rossi, M.J., Sundararaj, K., Koybasi, S., Phillips, M.S., Szulc, Z.M., Bielawska, A., Day, T.A., Obeid, L.M., Hannun, Y.A., Ogretmen, B. (2005). Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngol Head Neck Surg 132:55-62. [PubMed]