857450 | C6-Pyridinium-Ceramide

D-erythro-2-N-[6'-(1"-pyridinium)-hexanoyl]-sphingosine bromide


Powder

Size SKU Packaging Price
1mg 857450P-1mg 857450P-1mg 1 x 1mg $210.00
Base Price: ${originalprice|money}
Custom Packaging: (${concentration} @$4.00/ea. + $100) ${custompackagingtotal|money}
Packaging: ${concentration}
Item Total: ${totalprice|money}
Please select an option above.
${sku} - ${concentration}

C6-Pyridinium-Ceramide

C6-Pyridinium-Ceramide

D-erythro-2-N-[6'-(1"-pyridinium)-hexanoyl]-sphingosine bromide

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C29H51N2O3Br
Percent Composition
C 62.69%, H 9.25%, Br 14.38%, N 5.04%, O 8.64%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
853992-70-8
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
555.631
Exact Mass
554.308
Synonyms

D-erythro-C6-pyridinium-ceramide

LCL29

Separovic, D., Bielawski, J., Pierce, J.S., Merchant, S., Tarca, A.L., Ogretmen, B., Korbelik, M. (2009). Increased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas. Br J Cancer. 100:626-32. [PubMed]

PubMed ID: 19223911

Szulc, Z.M., Bielawski, J., Gracz, H., Gustilo, M., Mayroo, N., Hannun, Y.A., Obeid, L.M., Bielawska A. (2006). Tailoring structure-function and targeting properties of ceramides by site-specific cationization. Bioorg Med Chem. 14:7083-104. [PubMed]

PubMed ID: 16919460

Novgorodov, S.A., Szulc, Z.M., Luberto, C., Jones, J.A., Bielawski, J., Bielawska, A., Hannun, Y.A., Obeid, L.M. (2005). Positively charged ceramide is a potent inducer of mitochondrial permeabilization. J Biol Chem 280:16096-105. [PubMed]

PubMed ID: 15722351

Rossi, M.J., Sundararaj, K., Koybasi, S., Phillips, M.S., Szulc, Z.M., Bielawska, A., Day, T.A., Obeid, L.M., Hannun, Y.A., Ogretmen, B. (2005). Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngol Head Neck Surg 132:55-62. [PubMed]

PubMed ID: 15632910