857397 | NIBR189

(E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one


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NIBR189

NIBR189

(E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one

Potent and selective antagonist of the G protein-coupled receptor identified as EBI2 (GPR183) (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors, respectively). This compound exhibits selectivity for EBI2 over other receptors, enzymes and transporters. In addition, NIBR189 blocks oxysterol-induced migration of U937 monocyte cells.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C21H21BrN2O3
Percent Composition
C 58.75%, H 4.93%, Br 18.61%, N 6.53%, O 11.18%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
1599432-08-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
429.307
Exact Mass
428.074
Gessier, F., I. Preuss, H. Yin, M.M. Rosenkilde, S. Laurent, R. Endres, Y.A. Chen, T.H. Marsilje, K. Seuwen, D.G. Nguyen, and A.W. Sailer. (2014). Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.  J Med Chem 57:3358-68. [PubMed]