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NIBR189 | 857397

(E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one

857397P

Powder

10 mg
$195.00
50 mg
$780.00

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Potent and selective antagonist of the G protein-coupled receptor identified as EBI2 (GPR183) (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors, respectively). This compound exhibits selectivity for EBI2 over other receptors, enzymes and transporters. In addition, NIBR189 blocks oxysterol-induced migration of U937 monocyte cells.
Molecular Formula
C21H21BrN2O3
Percent Composition
C 58.75%, H 4.93%, Br 18.61%, N 6.53%, O 11.18%
Purity
>99%
Stability
6 months
Storage
-20°C
CAS Number
1599432-08-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
429.307
Exact Mass
428.074
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Notes
GIF Graphics File. 
GIF Graphics File. 
CDX File. 
Gessier, F., I. Preuss, H. Yin, M.M. Rosenkilde, S. Laurent, R. Endres, Y.A. Chen, T.H. Marsilje, K. Seuwen, D.G. Nguyen, and A.W. Sailer. (2014). Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.  J Med Chem 57:3358-68. [PubMed]