857395 | GT-11
N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide

GT-11
N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide
CAS Registry Number is a Registered Trademark of the American Chemical Society
- ChemDraw File
- 3D Structure
- Structure
- Safety Data Sheet
- Certificate of Analysis (Lot No. 857395P-1MG-A-010 and 5834PGA010)
- Certificate of Analysis (Lot No. 857395P-1MG-B-010 and 5834PGB010)
- Certificate of Analysis (Lot No. 857395P-1MG-C-010 and 5834PGC010)
- Certificate of Analysis (Lot No. 857395P-1MG-D-010 and 5834PGD010)
- Certificate of Analysis (Lot No. 857395P-1MG-A-010 and 5834PGA010)
Muñoz-Guardiola P, Casas J, Megías-Roda E, Solé S, Perez-Montoyo H, Yeste-Velasco M, Erazo T, Diéguez-Martínez N, Espinosa-Gil S, Muñoz-Pinedo C, Yoldi G, Abad JL, Segura MF, Moran T, Romeo M, Bosch-Barrera J, Oaknin A, Alfón J, Domènech C, Fabriàs G, Velasco G, Lizcano JM. The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells. Autophagy. 2020 May 25:1-18. doi: 10.1080/15548627.2020.1761651. Epub ahead of print. PMID: 32397857.
PubMed ID: 32397857Triola G, Fabrias G, Dragusin M, Niederhausen L, Broere R, Llebaria A, van Echten-Deckert G. Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11) in primary cultured cerebellar neurons. Mol Pharmacol. 2004 Dec;66(6):1671-8. doi: 10.1124/mol.104.003681. Epub 2004 Sep 15. PMID: 15371559.
PubMed ID: 15371559Orienti I, Francescangeli F, De Angelis ML, Fecchi K, Bongiorno-Borbone L, Signore M, Peschiaroli A, Boe A, Bruselles A, Costantino A, Eramo A, Salvati V, Sette G, Contavalli P, Zolla L, Oki T, Kitamura T, Spada M, Giuliani A, Baiocchi M, La Torre F, Melino G, Tartaglia M, De Maria R, Zeuner A. A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors. Cell Death Dis. 2019 Jul 23;10(7):529. doi: 10.1038/s41419-019-1775-y.
PubMed ID: 31332161