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(R)-FTY720-OMe | 857392

(R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol

857392O

Oil

1 mg
$125.00
5 mg
$495.00

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(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity.
Molecular Formula
C20H35NO2
Percent Composition
C 74.72%, H 10.97%, N 4.36%, O 9.95%
Purity
>99%
Stability
6 Months
Storage
-20°C
CAS Number
1382486-90-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
321.497
Exact Mass
321.267
Synonyms
(R)-FTY720-methyl ether
ROME
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Notes
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File. 
Watson, D.G., Tonelli, F., Alossaimi, M., Williamson, L., Chan, E., Gorshkova, I., Berdyshev, E., Bittman, R., Pyne, N.J., Pyne, S. (2013). The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. Cell Signal 25:1011-1017. [PubMed]

Tonelli, F., Alossaimi, M., Williamson, L., Tate, R.J., Watson, D.G., Chan, E., Bittman, R., Pyne, N.J., Pyne, S. (2013). The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism. Br J Pharmacol. 168(6):1497-505. [PubMed]

Lim, K.G., Sun, C., Bittman, R., Pyne, N.J., Pyne, S. (2011). (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cell Signal 23:1590-5. [PubMed]