857392 | (R)-FTY720-OMe
(R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol
(R)-FTY720-OMe
(R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol
(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity.
CAS Registry Number is a Registered Trademark of the American Chemical Society
ROME
Watson, D.G., Tonelli, F., Alossaimi, M., Williamson, L., Chan, E., Gorshkova, I., Berdyshev, E., Bittman, R., Pyne, N.J., Pyne, S. (2013). The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. Cell Signal 25:1011-1017. [PubMed]
PubMed ID: 23314175Tonelli, F., Alossaimi, M., Williamson, L., Tate, R.J., Watson, D.G., Chan, E., Bittman, R., Pyne, N.J., Pyne, S. (2013). The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism. Br J Pharmacol. 168(6):1497-505. [PubMed]
PubMed ID: 23113536Lim, K.G., Sun, C., Bittman, R., Pyne, N.J., Pyne, S. (2011). (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cell Signal 23:1590-5. [PubMed]
PubMed ID: 21620961- Certificate of Analysis (Lot No. 857392O-1MG-A-015 and 5832OGA015)