VPC 51299 | 857347
All Prices in US Dollars
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- VPC51299 is a potent low micromolar inhibitor containing a vinyl phosphonate head group and possessing a half-life of approximately 90 min in rats when dosed intravenously. Previously developed LPA1/LPA3 receptor antagonists contain a labile phosphate head group which impairs evaluation of scaffold LPA receptor antagonists in vivo. VPC51299 has replaced the phosphate with a more stable head group while retaining potency at both LPA1 and LPA3 to facilitate future in vivo studies of the biological functions of these receptors.
Refer: J.E. East, et al. (2011). Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist. Medchemcomm 2:325-330.
This product is covered by Patent Number US 8,283,339 B2. Avanti manufactures this under license from University of Virginia.
- Molecular Formula
- C34H50 F3N2O6P
- Percent Composition
- C 60.88%, H 7.51%, F 8.50%, N 4.18%, O 14.31%, P 4.62%
- 6 months
- Molecular Weight
- Exact Mass