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(2S)-OMPT | 857235

1-oleoyl-2-methyl-sn-glycero-3-phosphothionate (ammonium salt)

857235P

500 μg Powder

1 ea
$95.00

1000 μg Powder

1 ea
$171.00

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OMPT is a selective agonist of the LPA3 receptor. It exhibits EC50 values of 68 nM and >6.8 µM for calcium mobilization in LPA3 and LPA2-expressing Sf9 cells, respectively.1 The (2S)-OMPT enantiomer is 5- to 20-fold more active than (2R)-OMPT in calcium release assays in both LPA3-transfected Sf9 and rat hepatoma Rh7777 cells.2
1. Hasegawa, Y., Erickson, J.R., Goddard, G.J., Yu, S., Liu, S., Cheng, K.W., Eder, A., Bandoh, K., Aoki, J., Jarosz, R., Schrier, A.D., Lynch, K.R., Mills, G.B., Fang, X. (2003) Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor. J Biol Chem 278:11962-11969.
2. Qian, L., Xu, Y., Hasegawa, Y., Aoki, J., Mills, G.B., Prestwich, G.D. (2003) Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity. J Med Chem 46:5575-5578.
Molecular Formula
C22H46NO6PS
Percent Composition
C 54.63%, H 9.59%, N 2.90%, O 19.85%, P 6.40%, S 6.63%
Purity
>99%
Stability
1 Years
Storage
-20°C
CAS Number
799268-70-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
483.643
Exact Mass
483.278
Synonyms
(2S)-1-(9Z-octadecenoyl)-2-O-methyl-glycero-3-phosphothionate (ammonium salt)
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Notes
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File. 
Hasegawa, Y., Erickson, J.R., Goddard, G.J., Yu, S., Liu, S., Cheng, K.W., Eder, A., Bandoh, K., Aoki, J., Jarosz, R., Schrier, A.D., Lynch, K.R., Mills, G.B., Fang, X. (2003)Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor. J Biol Chem 278:11962-11969.Qian, L., Xu, Y., Hasegawa, Y., Aoki, J., Mills, G.B., Prestwich, G.D. (2003)Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity. J Med Chem 46:5575-5578.