857120 | 14:0 Lyso PA

1-myristoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)


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14:0 Lyso PA

14:0 Lyso PA

1-myristoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)

Hygroscopic
Yes
Light Sensitive
No
Molecular Formula
C17H34O7PNa
Percent Composition
C 50.49%, H 8.47%, Na 5.68%, O 27.69%, P 7.66%
Purity
>99% LPA; may contain up to 10% of the 2-LPA isomer
Stability
1 Year
Storage Temperature
-20°C
CAS Number
325465-45-0
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
404.411
Exact Mass
404.194
Synonyms
myristoyl lysophosphatidic acid
1-tetradecanoyl-sn-glycero-3-phosphate (sodium salt)
PA(14:0/0:0)
14:0 LPA
110677

Vaz FM, McDermott JH, Alders M, Wortmann SB, Kölker S, Pras-Raves ML, Vervaart MAT, van Lenthe H, Luyf ACM, Elfrink HL, Metcalfe K, Cuvertino S, Clayton PE, Yarwood R, Lowe MP, Lovell S, Rogers RC; Deciphering Developmental Disorders Study, van Kampen AHC, Ruiter JPN, Wanders RJA, Ferdinandusse S, van Weeghel M, Engelen M, Banka S. Mutations in PCYT2 disrupt etherlipid biosynthesis and cause a complex hereditary spastic paraplegia. Brain. 2019 Nov 1;142(11):3382-3397. doi: 10.1093/brain/awz291.

PubMed ID: 31637422

Huffnagel IC, Dijkgraaf MGW, Janssens GE, van Weeghel M, van Geel BM, Poll-The BT, Kemp S, Engelen M. Disease progression in women with X-linked adrenoleukodystrophy is slow. Orphanet J Rare Dis. 2019 Feb 7;14(1):30. doi: 10.1186/s13023-019-1008-6.

PubMed ID: 30732635

Kano K, Matsumoto H, Inoue A, Yukiura H, Kanai M, Chun J, Ishii S, Shimizu T, Aoki J. Molecular mechanism of lysophosphatidic acid-induced hypertensive response. Sci Rep. 2019 Feb 25;9(1):2662. doi: 10.1038/s41598-019-39041-4.

PubMed ID: 30804442

Williams, J.R., Khandoga, A.L., Goyal, P., Fells, J.I., Perygin, D.H., Siess, W., Parrill, A..L, Tigyi, G., Fujiwara, Y. (2009) Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J Biol Chem. 284:17304-19. [PubMed]

PubMed ID: 19366702