850757 | 16:0-18:1 PE

1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine


Powder

Size SKU Packaging Price
25mg 850757P-25mg 850757P-25mg 1 x 25mg $69.00
200mg 850757P-200mg 850757P-200mg 2 x 100mg $206.00
500mg 850757P-500mg 850757P-500mg 5 x 100mg $370.00
1g 850757P-1g 850757P-1g 1 x 1g $540.00

Chloroform

Size SKU Packaging Price
25mg 850757C-25mg 850757C-25mg 1 x 25mg 10mg/mL 2.5mL $69.00
200mg 850757C-200mg 850757C-200mg 2 x 100mg 25mg/mL 4mL $206.00
500mg 850757C-500mg 850757C-500mg 5 x 100mg 25mg/mL 4mL $370.00
1g 850757C-1g 850757C-1g 2 x 500mg 25mg/mL 20mL $540.00
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16:0-18:1 PE

16:0-18:1 PE

1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine

Hygroscopic
Yes
Light Sensitive
No
Molecular Formula
C39H76NO8P
Percent Composition
C 65.24%, H 10.67%, N 1.95%, O 17.83%, P 4.31%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
26662-94-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
717.996
Exact Mass
717.531
Synonyms
<p>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine</p> <p>POPE</p> <p>PE(16:0/18:1(9Z))&nbsp;</p> <p>110637</p>

Bao H, Goldschen-Ohm M, Jeggle P, Chanda B, Edwardson JM, Chapman ER. Exocytotic fusion pores are composed of both lipids and proteins. Nat Struct Mol Biol. 2016 Jan;23(1):67-73. doi: 10.1038/nsmb.3141. Epub 2015 Dec 14.

PubMed ID: 26656855

Harmouche N, Bechinger B. Lipid-Mediated Interactions between the Antimicrobial Peptides Magainin 2 and PGLa in Bilayers. Biophys J. 2018 Aug 16. pii: S0006-3495(18)30936-6. doi: 10.1016/j.bpj.2018.08.009. [Epub ahead of print]

PubMed ID: 30195937

Kimble-Hill AC, Petrache HI, Seifert S, Firestone MA. Reorganization of Ternary Lipid Mixtures of Nonphosphorylated Phosphatidylinositol Interacting with Angiomotin. J Phys Chem B. 2018 Aug 27. doi: 10.1021/acs.jpcb.7b12641. [Epub ahead of print]

PubMed ID: 29877706

Cao W, Ma X, Li Z, Zhou X, Ouyang Z. Locating Carbon-Carbon Double Bonds in Unsaturated Phospholipids by Epoxidation Reaction and Tandem Mass Spectrometry. Anal Chem. 2018 Aug 23. doi: 10.1021/acs.analchem.8b02021. [Epub ahead of print]

PubMed ID: 30095894

Prior studies have shown that the biological mixture of the two hydrophobic surfactant proteins, SP-B and SP-C, produces faster adsorption of the surfactant lipids to an air/water interface, and that they induce 1-palmitoyl-2-oleoyl phosphatidylethanolamine (POPE) to form inverse bicontinuous cubic phases. Previous studies have shown that SP-B has a much greater effect than SP-C on adsorption. If the two proteins induce faster adsorption and formation of the bicontinuous structures by similar mechanisms, then they should also have different abilities to form the cubic phases. To test this hypothesis, we measured small-angle X-ray scattering on the individual proteins combined with POPE. SP-B replicated the dose-related ability of the combined proteins to induce the cubic phases at temperatures more than 25 degrees C below the point at which POPE alone forms the curved inverse-hexagonal phase. With SP-C, diffraction from cubic structures was either absent or present at very low intensities only with larger amounts of protein. The correlation between the structural effects of inducing curved structures and the functional effects on the rate of adsorption fits with the model in which SP-B promotes adsorption by facilitating formation of an inversely curved, rate-limiting structure.


Chavarha, M., R.W. Loney, K. Kumar, S.B. Rananavare, and S.B. Hall. (2012). Differential effects of the hydrophobic surfactant proteins on the formation of inverse bicontinuous cubic phases. Langmuir 28:16596-604.

PubMed ID: 23140329

Disordering Effects of Digitonin on Phospholipid Monolayers M. Orczyk, K. Wojciechowski , and G. Brezesinski Langmuir, Article ASAP

PubMed ID: 28333465

Charles G. Cranfield, Sónia Troeira Henriques, Boris Martinac, Paul Duckworth, David J. Craik and Bruce Cornell. Kalata B1 and Kalata B2 Have a Surfactant-Like Activity in Phosphatidylethanolomine-Containing Lipid Membranes. Langmuir, Article ASAP

PubMed ID: 28605904

Jordi H. Borrell and Òscar Domènech. Critical Temperature of 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine Monolayers and Its Possible Biological Relevance. J. Phys. Chem. B, Article ASAP

PubMed ID: 28636818

Saba Ghazvini, Ryan Alonso, Nabil Alhakamy, and Prajnaparamita Dhar. pH induced changes in the surface viscosity of unsaturated phospholipids monitored using active interfacial microrheology. Langmuir, Just Accepted Manuscript

PubMed ID: 29019691

Silva T, Claro B, Silva BFB, Vale N, Gomes P, Gomes MS, Funari SS, Teixeira J, Uhríková D, Bastos M. Unravelling a Mechanism of Action for a Cecropin A-Melittin Hybrid Antimicrobial Peptide: The Induced Formation of Multilamellar Lipid Stacks. Langmuir. 2018 Jan 22. doi: 10.1021/acs.langmuir.7b03639.

PubMed ID: 29304549

Li G, Kim J, Huang Z, St Clair JR, Brown DA, London E. Efficient replacement of plasma membrane outer leaflet phospholipids and sphingolipids in cells with exogenous lipids. Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14025-14030. Epub 2016 Nov 21.

PubMed ID: 27872310