850540 | MEGA-8

N-octanoyl-N-methylglucamine

MEGA-8

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1g 850540P-1g 850540P-1g 1 x 1g $91.63
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Info

MEGA-8

N-octanoyl-N-methylglucamine

Acyl-N-methylglucamide (MEGA) detergents are non-ionic detergents that provide a good starting point for your structural biology work. The hydrophilic head groups offer ample strength to extract proteins while still providing the capability to stabilize proteins in solution and promote crystal growth.

Data
Hygroscopic
No
Light Sensitive
No
Percent Composition
C 56.05%, H 9.72%, N 4.36%, O 29.87%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
85316-98-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
321.41
Exact Mass
321.215
CMC
~79mM
References

Chuang JH, Kao YJ, Ruderman NB, Tung LC, Lin Y. Optimal concentrations of N-decanoyl-N-methylglucamine and sodium dodecyl sulfate allow the extraction and analysis of membrane proteins. Anal Biochem. 2011 Nov 15;418(2):298-300. doi: 10.1016/j.ab.2011.08.006. Epub 2011 Aug 10. PMID: 21871431.

PubMed ID: 21871431

Churchward MA, Butt RH, Lang JC, Hsu KK, Coorssen JR. Enhanced detergent extraction for analysis of membrane proteomes by two-dimensional gel electrophoresis. Proteome Sci. 2005 Jun 7;3(1):5. doi: 10.1186/1477-5956-3-5. PMID: 15941475; PMCID: PMC1184097.

PubMed ID: 15941475

Hierrezuelo JM, Aguiar J, Ruiz CC. Stability, interaction, size, and microenvironmental properties of mixed micelles of decanoyl-N-methylglucamide and sodium dodecyl sulfate. Langmuir. 2004 Nov 23;20(24):10419-26. doi: 10.1021/la048278i. PMID: 15544368.

PubMed ID: 15544368

Hanatani M, Nishifuji K, Futai M, Tsuchiya T. Solubilization and reconstitution of membrane proteins of Escherichia coli using alkanoyl-N-methylglucamides. J Biochem. 1984 May;95(5):1349-53. doi: 10.1093/oxfordjournals.jbchem.a134742. PMID: 6235214.

PubMed ID: 6235214

Hildreth JE. N-D-Gluco-N-methylalkanamide compounds, a new class of non-ionic detergents for membrane biochemistry. Biochem J. 1982 Nov 1;207(2):363-6. doi: 10.1042/bj2070363. PMID: 7159387; PMCID: PMC1153869.

PubMed ID: 7159387
Certificates of Analysis

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