850536 | 8.8 MAG

1-(8Z-hexadecenoyl)-rac-glycerol


Oil

Size SKU Packaging Price
25mg 850536O-25mg 850536O-25mg 1 x 25mg $163.50
1g 850536O-1g 850536O-1g 10 x 100mg $2,050.00
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8.8 MAG

8.8 MAG

1-(8Z-hexadecenoyl)-rac-glycerol

This new Lipid detergent may be used for crystallizing membrane proteins by using lipidic mesophases. This method has variously been referred to as the lipidic cubic phase or in meso method. The method has been shown to be quite versatile in that it has been used to solve X-ray crystallographic structures of prokaryotic and eukaryotic proteins, proteins that are monomeric, homo- and hetero-multimeric, chromophore-containing and chromophore-free, and alpha-helical and beta-barrel proteins.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C19H36O4
Percent Composition
C 69.47%, H 11.05%, O 19.48%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
749266-38-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
328.487
Exact Mass
328.261

Johner N, Mondal S, Morra G, Caffrey M, Weinstein H, Khelashvili G. Protein and lipid interactions driving molecular mechanisms of in meso crystallization. J Am Chem Soc. 2014 Feb 26;136(8):3271-84. doi: 10.1021/ja4129839. Epub 2014 Feb 14. PMID: 24494670; PMCID: PMC3985912.

PubMed ID: 24494670

Caffrey M, Porter C. Crystallizing membrane proteins for structure determination using lipidic mesophases. J Vis Exp. 2010 Nov 21;(45):1712. doi: 10.3791/1712. PMID: 21113125; PMCID: PMC3144658.

PubMed ID: 21113125

Caffrey M, Cherezov V. Crystallizing membrane proteins using lipidic mesophases. Nat Protoc. 2009;4(5):706-31. doi: 10.1038/nprot.2009.31. PMID: 19390528; PMCID: PMC2732203.

PubMed ID: 19390528

Höfer N, Aragão D, Caffrey M. Crystallizing transmembrane peptides in lipidic mesophases. Biophys J. 2010 Aug 4;99(3):L23-5. doi: 10.1016/j.bpj.2010.05.011. PMID: 20682243; PMCID: PMC2913208.

PubMed ID: 20682243

Misquitta LV, Misquitta Y, Cherezov V, Slattery O, Mohan JM, Hart D, Zhalnina M, Cramer WA, Caffrey M. Membrane protein crystallization in lipidic mesophases with tailored bilayers. Structure. 2004 Dec;12(12):2113-24. doi: 10.1016/j.str.2004.09.020. PMID: 15576026.

PubMed ID: 15576026