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7.8 MAG | 850531




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1 g

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This new Lipid detergent may be used for crystallizing membrane proteins by using lipidic mesophases. This method has variously been referred to as the lipidic cubic phase or in meso method. The method has been shown to be quite versatile in that it has been used to solve X-ray crystallographic structures of prokaryotic and eukaryotic proteins, proteins that are monomeric, homo- and hetero-multimeric, chromophore-containing and chromophore-free, and alpha-helical and beta-barrel proteins.
Molecular Formula
Percent Composition
C 68.75%, H 10.90%, O 20.35%
6 Months
CAS Number
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
Exact Mass
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File. 
Johner, N., S. Mondal, G. Morra, M. Caffrey, H. Weinstein, and G. Khelashvili. (2014). Protein and Lipid Interactions Driving Molecular Mechanisms of in meso Crystallization. J Am Chem Soc [PubMed]

Caffrey, M. and C. Porter. (2010). Crystallizing membrane proteins for structure determination using lipidic mesophases. J Vis Exp 2010 Nov 21;(45). pii: 1712. doi: 10.3791/1712. [PubMed]

Caffrey, M. and V. Cherezov. (2009). Crystallizing membrane proteins using lipidic mesophases. Nat Protoc 4:706-31. [PubMed]

Hofer, N., D. Aragao, and M. Caffrey. (2010). Crystallizing transmembrane peptides in lipidic mesophases. Biophys J 99:L23-5. [PubMed]

Misquitta, L.V., Y. Misquitta, V. Cherezov, O. Slattery, J.M. Mohan, D. Hart, M. Zhalnina, W.A. Cramer, and M. Caffrey. (2004). Membrane protein crystallization in lipidic mesophases with tailored bilayers. Structure 12:2113-24. [PubMed]