850522 | Facade®-EM

3α-hydroxy-7α,12α-di-((O-ß-D-maltosyl)-2-hydroxyethoxy)-cholaneExclusively from Avanti


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Size SKU Packaging Price
25mg 850522P-25mg 850522P-25mg 1 x 25mg $152.00
200mg 850522P-200mg 850522P-200mg 1 x 200mg $500.00
1g 850522P-1g 850522P-1g 1 x 1g $1,900.00
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Facade®-EM

Facade®-EM

3α-hydroxy-7α,12α-di-((O-ß-D-maltosyl)-2-hydroxyethoxy)-cholaneExclusively from Avanti

Exclusively from Avanti

Façade-EM is a two-dimensional amphiphile with hydrophobic and hydrophilic faces that has superior ability to stabilize integral membrane proteins. This new class of detergents represents a departure from traditional one-dimensional polar-head/nonpolar-tail molecules.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C52H90O25
Percent Composition
C 56.00%, H 8.13%, O 35.86%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
1429405-95-7
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
1115.256
Exact Mass
1114.577
Synonyms
<p>FA-3</p> <p>3α-hydroxy-7α,12α-di-((O-ß-D-maltopyranosyl)ethyloxy)-cholane</p>

Ho H, Miu A, Alexander MK, Garcia NK, Oh A, Zilberleyb I, Reichelt M, Austin CD, Tam C, Shriver S, Hu H, Labadie SS, Liang J, Wang L, Wang J, Lu Y, Purkey HE, Quinn J, Franke Y, Clark K, Beresini MH, Tan MW, Sellers BD, Maurer T, Koehler MFT, Wecksler AT, Kiefer JR, Verma V, Xu Y, Nishiyama M, Payandeh J, Koth CM. Structural basis for dual-mode inhibition of the ABC transporter MsbA. Nature. 2018 May;557(7704):196-201.

PubMed ID: 29720648

Lee, S.C., B.C. Bennett, W.X. Hong, Y. Fu, K.A. Baker, J. Marcoux, C.V. Robinson, A.B. Ward, J.R. Halpert, R.C. Stevens, C.D. Stout, M.J. Yeager, and Q. Zhang. (2013). Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins. Proc Natl Acad Sci U S A 110:E1203-11. [PubMed]

PubMed ID: 23479627

Zhang, Q., X. Ma, A. Ward, W.X. Hong, V.P. Jaakola, R.C. Stevens, M.G. Finn, and G. Chang. (2007) Designing facial amphiphiles for the stabilization of integral membrane proteins. Angew Chem Int Ed Engl 46:7023-5. [PubMed]

PubMed ID: 17691085


Kot EF, Goncharuk SA, Arseniev AS, Mineev KS. Phase Transitions in Small Isotropic Bicelles. Langmuir. 2018 Mar 6. doi: 10.1021/acs.langmuir.7b03610.

PubMed ID: 29486112