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n-dodecyl-ß-D-maltoside (DDM) | 850520

n-dodecyl-β-D-maltopyranoside

850520P

Powder

25 g
$1460.00
1 g
$105.00
5 g
$385.00
10 g
$690.00

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DDM is the most widely used detergent for the isolation and purification of GPCR’s.
 
In addition, LacY likely favors a higher-energy intermediate periplasmic-open conformation in situ, but collapses to a lower-energy periplasmic-closed conformation in DDM after purification. It is interesting to note that the branched-chain maltoside detergents stabilize LacY in the membrane-embedded form (see Related Products).
Molecular Formula
C24H46O11
Percent Composition
C 56.45%, H 9.08%, O 34.47%
Purity
>99%; contains <2% alpha isomer
Stability
1 Years
Storage
-20°C
CAS Number
69227-93-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
510.615
Exact Mass
510.304
CMC
~0.2 mM
Synonyms
DDM
lauryl maltoside
dodecyl 4-O-α-D-glucopyranosyl-β-D-glucopyranoside
Jiang, X., L. Guan, Y. Zhou, W.X. Hong, Q. Zhang, and H.R. Kaback. (2012). Evidence for an intermediate conformational state of LacY. Proc Natl Acad Sci U S A 109:E698-704. [PubMed]

Thompson, A.A., J.J. Liu, E. Chun, D. Wacker, H. Wu, V. Cherezov, and R.C. Stevens. (2011). GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles. Methods 55:310-7. [PubMed]