850520 | n-dodecyl-ß-D-maltoside (DDM)

n-dodecyl-β-D-maltopyranoside

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1g 850520P-1g 850520P-1g 1 x 1g $124.31
5g 850520P-5g 850520P-5g 1 x 5g $456.55
25g 850520P-25g 850520P-25g 1 x 25g $1,732.50
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n-dodecyl-ß-D-maltoside (DDM)

n-dodecyl-ß-D-maltoside (DDM)

n-dodecyl-β-D-maltopyranoside

DDM is the most widely used detergent for the isolation and purification of GPCR’s.
In addition, LacY likely favors a higher-energy intermediate periplasmic-open conformation in situ, but collapses to a lower-energy periplasmic-closed conformation in DDM after purification. It is interesting to note that the branched-chain maltoside detergents stabilize LacY in the membrane-embedded form (see Related Products).
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C24H46O11
Percent Composition
C 56.45%, H 9.08%, O 34.47%
Purity
>99%; contains <2% alpha isomer
Stability
1 Years
Storage Temperature
-20°C
CAS Number
69227-93-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
510.615
Exact Mass
510.304
Synonyms
DDM
lauryl maltosidedodecyl
4-O-α-D-glucopyranosyl-β-D-glucopyranoside

Carey Hulyer AR, Briggs DA, O'Mara ML, Kerr ID, Harmer JR, Callaghan R. Cross-linking, DEER-spectroscopy and molecular dynamics confirm the inward facing state of P-glycoprotein in a lipid membrane. J Struct Biol. 2020 Apr 24:107513. doi: 10.1016/j.jsb.2020.107513. Epub ahead of print. PMID: 32339763.

 PubMed ID: 32339763

Do T, Schaefer K, Santiago AG, Coe KA, Fernandes PB, Kahne D, Pinho MG, Walker S. Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan. Nat Microbiol. 2020 Feb;5(2):291-303. doi: 10.1038/s41564-019-0632-1. Epub 2020 Jan 13. PMID: 31932712.

 PubMed ID: 31932712

Sinha R, Siddiqui TJ, Padmanabhan N, Wallin J, Zhang C, Karimi B, Rieke F, Craig AM, Wong RO, Hoon M. LRRTM4: A Novel Regulator of Presynaptic Inhibition and Ribbon Synapse Arrangements of Retinal Bipolar Cells. Neuron. 2020 Jan 8:S0896-6273(19)31094-3. doi: 10.1016/j.neuron.2019.12.028. Epub ahead of print. PMID: 31974009.

 PubMed ID: 31974009

Roppongi RT, Dhume SH, Padmanabhan N, Silwal P, Zahra N, Karimi B, Bomkamp C, Patil CS, Champagne-Jorgensen K, Twilley RE, Zhang P, Jackson MF, Siddiqui TJ. LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ. Neuron. 2020 Jan 23:S0896-6273(20)30003-9. doi: 10.1016/j.neuron.2020.01.003. Epub ahead of print. PMID: 31995730.

 PubMed ID: 31995730

Ghysels A, Krämer A, Venable RM, Teague WE Jr, Lyman E, Gawrisch K, Pastor RW. Permeability of membranes in the liquid ordered and liquid disordered phases. Nat Commun. 2019 Dec 9;10(1):5616. doi: 10.1038/s41467-019-13432-7.

 PubMed ID: 31811124

Jiang X, Guan L, Zhou Y, Hong WX, Zhang Q, Kaback HR. Evidence for an intermediate conformational state of LacY. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):E698-704. doi: 10.1073/pnas.1201107109. Epub 2012 Feb 21.

 PubMed ID: 22355148

Thompson, A.A., J.J. Liu, E. Chun, D. Wacker, H. Wu, V. Cherezov, and R.C. Stevens. (2011). GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles. Methods 55:310-7. doi: 10.1016/j.ymeth.2011.10.011

 PubMed ID: 22041719