850520 | n-dodecyl-ß-D-maltoside (DDM)

n-dodecyl-β-D-maltopyranoside

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1g 850520P-1g 850520P-1g 1 x 1g $115.50
5g 850520P-5g 850520P-5g 1 x 5g $424.20
25g 850520P-25g 850520P-25g 1 x 25g $1,609.75
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n-dodecyl-ß-D-maltoside (DDM)

n-dodecyl-ß-D-maltoside (DDM)

n-dodecyl-β-D-maltopyranoside

DDM is the most widely used detergent for the isolation and purification of GPCR’s.
In addition, LacY likely favors a higher-energy intermediate periplasmic-open conformation in situ, but collapses to a lower-energy periplasmic-closed conformation in DDM after purification. It is interesting to note that the branched-chain maltoside detergents stabilize LacY in the membrane-embedded form (see Related Products).
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C24H46O11
Percent Composition
C 56.45%, H 9.08%, O 34.47%
Purity
>99%; contains <2% alpha isomer
Stability
1 Years
Storage Temperature
-20°C
CAS Number
69227-93-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
510.615
Exact Mass
510.304
Synonyms
<p>DDMlauryl maltosidedodecyl 4-O-α-D-glucopyranosyl-β-D-glucopyranoside</p>

Jiang X, Guan L, Zhou Y, Hong WX, Zhang Q, Kaback HR. Evidence for an intermediate conformational state of LacY. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):E698-704. doi: 10.1073/pnas.1201107109. Epub 2012 Feb 21.

 PubMed ID: 22355148

Thompson, A.A., J.J. Liu, E. Chun, D. Wacker, H. Wu, V. Cherezov, and R.C. Stevens. (2011). GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles. Methods 55:310-7. doi: 10.1016/j.ymeth.2011.10.011

 PubMed ID: 22041719