850500 | CHAPS

3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate


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1g 850500P-1g 850500P-1g 1 x 1g $41.00
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CHAPS

CHAPS

3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate

CHAPS is a nondenaturing zwitterionic detergent for membrane biochemistry. Useful for solubilizing membrane proteins and breaking protein-protein interactions. CHAPS’ small micellar molecular weight (6,150; aggregation number = 10) and high critical micelle concentration (6-10 mM) allow it to be removed from samples by dialysis. It is also suitable for protein solubilization for isoelectric focusing and two-dimensional electrophoresis. CHAPS is commonly used for non-denaturing (without urea) IEF and has been shown to give excellent resolution of some subcellular preparations and plant proteins. Concentrations between 2-4% (w/v) are typically used in an IEF gel.
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C32H58N2O7S
Percent Composition
C 62.51%, H 9.51%, N 4.56%, O 18.21%, S 5.21%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
75621-03-3
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
614.877
Exact Mass
614.396

Kot EF, Arseniev AS, Mineev KS. On the behavior of most widely spread lipids in isotropic bicelles. Langmuir. 2018 Jun 20. doi: 10.1021/acs.langmuir.8b01454. [Epub ahead of print]

PubMed ID: 29924628

Cordwell, S.J. (2008) Sequential extraction of proteins by chemical reagents. Methods Mol Biol. 424:139-46.

PubMed ID: 18369859

Kot EF, Goncharuk SA, Arseniev AS, Mineev KS. Phase Transitions in Small Isotropic Bicelles. Langmuir. 2018 Mar 6. doi: 10.1021/acs.langmuir.7b03610.

PubMed ID: 29486112