850457 | 16:0-18:1 PC (POPC)

1-palmitoyl-2-oleoyl-glycero-3-phosphocholine


Chloroform

Size SKU Packaging Price
25mg 850457C-25mg 850457C-25mg 1 x 25mg 10mg/mL 2.5mL $67.00
200mg 850457C-200mg 850457C-200mg 2 x 100mg 25mg/mL 4mL $174.00
500mg 850457C-500mg 850457C-500mg 5 x 100mg 25mg/mL 4mL $305.00
1g 850457C-1g 850457C-1g 2 x 500mg 25mg/mL 20mL $450.00

Powder

Size SKU Packaging Price
25mg 850457P-25mg 850457P-25mg 1 x 25mg $67.00
200mg 850457P-200mg 850457P-200mg 2 x 100mg $174.00
500mg 850457P-500mg 850457P-500mg 5 x 100mg $305.00
1g 850457P-1g 850457P-1g 1 x 1g $450.00
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16:0-18:1 PC (POPC)

16:0-18:1 PC (POPC)

1-palmitoyl-2-oleoyl-glycero-3-phosphocholine

POPC is typically considered one of the model lipids for biophysical experiments. The fatty acid composition, i.e., saturated chain in the sn-1 position and unsaturated chain in the sn-2 position, mimics mammalian phospholipid composition. Since the major constituent in Egg PC is 1-palmitoyl-2-oleoyl PC, POPC is an excellent synthetic substitute for EPC.

Hygroscopic
Yes
Light Sensitive
No
Molecular Formula
C42H82NO8P
Percent Composition
C 66.37%, H 10.87%, N 1.84%, O 16.84%, P 4.08%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
26853-31-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
760.076
Exact Mass
759.578
Synonyms
<p>1-hexadecanoyl-2--(9Z-octadecenoyl)-sn-glycero-3-phosphocholine</p> <p>POPC</p> <p>PC(16:0/18:1(9Z))</p>

Yano Y, Hanashima S, Yasuda T, Tsuchikawa H, Matsumori N, Kinoshita M, Al Sazzad MA, Slotte JP, Murata M. Sphingomyelin Stereoisomers Reveal That Homophilic Interactions Cause Nanodomain Formation. Biophys J. 2018 Oct 16;115(8):1530-1540. doi: 10.1016/j.bpj.2018.08.042. Epub 2018 Sep 7.

PubMed ID: 30274830

Skar-Gislinge N, Johansen NT, Høiberg-Nielsen R, Arleth L. Comprehensive Study of the Self-Assembly of Phospholipid Nanodiscs: What Determines Their Shape and Stoichiometry? Langmuir. 2018 Oct 10. doi: 10.1021/acs.langmuir.8b01503. [Epub ahead of print]

PubMed ID: 30239200

Skar-Gislinge N, Johansen NT, Høiberg-Nielsen R, Arleth L. A comprehensive study of the self-assembly of phospholipid nanodiscs: What determines their shape and stoichiometry? Langmuir. 2018 Sep 21. doi: 10.1021/acs.langmuir.8b01503. [Epub ahead of print]

PubMed ID: 30239200

Becher S, Esch P, Heiles S. Relative Quantification of Phosphatidylcholine sn-Isomers Using Positive Doubly Charged Lipid-Metal Ion Complexes. Anal Chem. 2018 Sep 21. doi: 10.1021/acs.analchem.8b02731. [Epub ahead of print]

PubMed ID: 30199242

Bao H, Goldschen-Ohm M, Jeggle P, Chanda B, Edwardson JM, Chapman ER. Exocytotic fusion pores are composed of both lipids and proteins. Nat Struct Mol Biol. 2016 Jan;23(1):67-73. doi: 10.1038/nsmb.3141. Epub 2015 Dec 14.

PubMed ID: 26656855

Bao H, Goldschen-Ohm M, Jeggle P, Chanda B, Edwardson JM, Chapman ER. Exocytotic fusion pores are composed of both lipids and proteins. Nat Struct Mol Biol. 2016 Jan;23(1):67-73. doi: 10.1038/nsmb.3141. Epub 2015 Dec 14.

PubMed ID: 26656855

Bao H, Das D, Courtney NA, Jiang Y, Briguglio JS, Lou X, Roston D, Cui Q, Chanda B, Chapman ER. Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties. Nature. 2018 Feb 8;554(7691):260-263. doi: 10.1038/nature25481. Epub 2018 Jan 31.

PubMed ID: 29420480

Harmouche N, Bechinger B. Lipid-Mediated Interactions between the Antimicrobial Peptides Magainin 2 and PGLa in Bilayers. Biophys J. 2018 Aug 16. pii: S0006-3495(18)30936-6. doi: 10.1016/j.bpj.2018.08.009. [Epub ahead of print]

PubMed ID: 30195937

Bryce DA, Kitt JP, Harris JM. Confocal Raman Microscopy for Label-Free Detection of Protein-Ligand Binding at Nanopore-Supported Phospholipid Bilayers. Anal Chem. 2018 Sep 13. doi: 10.1021/acs.analchem.8b02791. [Epub ahead of print]

PubMed ID: 30175578

Ceccon A, Clore GM, Tugarinov V. Decorrelating Kinetic and Relaxation Parameters in Exchange Saturation Transfer NMR: A Case Study of N-Terminal Huntingtin Peptides Binding to Unilamellar Lipid Vesicles. J Phys Chem B. 2018 Sep 12. doi: 10.1021/acs.jpcb.8b07112. [Epub ahead of print]

PubMed ID: 30156416

Kimble-Hill AC, Petrache HI, Seifert S, Firestone MA. Reorganization of Ternary Lipid Mixtures of Nonphosphorylated Phosphatidylinositol Interacting with Angiomotin. J Phys Chem B. 2018 Aug 27. doi: 10.1021/acs.jpcb.7b12641. [Epub ahead of print]

PubMed ID: 29877706

Cao W, Ma X, Li Z, Zhou X, Ouyang Z. Locating Carbon-Carbon Double Bonds in Unsaturated Phospholipids by Epoxidation Reaction and Tandem Mass Spectrometry. Anal Chem. 2018 Aug 23. doi: 10.1021/acs.analchem.8b02021. [Epub ahead of print]

PubMed ID: 30095894

Kawai C, Ferreira JC, Baptista MS, Nantes IL. Not only oxidation of cardiolipin affects the affinity of cytochrome C for lipid bilayers. J Phys Chem B. 2014 Oct 16;118(41):11863-72. doi: 10.1021/jp504518g. Epub 2014 Oct 6.

PubMed ID: 25247479

Rupert DLM, Mapar M, Shelke GV, Norling K, Elmeskog M, Lötvall JO, Block S, Bally M, Agnarsson B, Höök F. Effective Refractive Index and Lipid Content of Extracellular Vesicles Revealed Using Optical Waveguide Scattering and Fluorescence Microscopy. Langmuir. 2018 Jul 24;34(29):8522-8531. doi: 10.1021/acs.langmuir.7b04214. Epub 2018 Jul 11.

PubMed ID: 29923735

Meker S, Chin H, Sut TN, Cho NJ. Amyloid-β Peptide Triggers Membrane Remodeling in Supported Lipid Bilayers Depending on Their Hydrophobic Thickness. Langmuir. 2018 Jul 18. doi: 10.1021/acs.langmuir.8b01196. [Epub ahead of print]

PubMed ID: 30021071

Movsesian N, Tittensor M, Dianat G, Gupta M, Malmstadt N. Giant Lipid Vesicle Formation Using Vapor-Deposited Charged Porous Polymers. Langmuir. 2018 Jul 17. doi: 10.1021/acs.langmuir.8b00736. [Epub ahead of print]

PubMed ID: 29961336

Walsh SM, Mathiasen S, Christensen SM, Fay JF, King C, Provasi D, Borrero E, Rasmussen SGF, Fung JJ, Filizola M, Hristova K, Kobilka B, Farrens DL, Stamou D. Single Proteoliposome High-Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs. Biophys J. 2018 Jul 17;115(2):300-312. doi: 10.1016/j.bpj.2018.05.036.

PubMed ID: 30021106

Pittman AE, Marsh BP, King GM. Conformations and Dynamic Transitions of a Melittin Derivative That Forms Macromolecule-Sized Pores in Lipid Bilayers. Langmuir. 2018 Jul 9. doi: 10.1021/acs.langmuir.8b00804. [Epub ahead of print]

PubMed ID: 29933696

Piffoux M, Silva AKA, Wilhelm C, Gazeau F, Tareste D. Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems. ACS Nano. 2018 Jul 10. doi: 10.1021/acsnano.8b02053. [Epub ahead of print]

PubMed ID: 29975503

Movsesian N, Tittensor M, Dianat G, Gupta M, Malmstadt N. Giant Lipid Vesicle Formation Using Vapor-Deposited Charged Porous Polymers. Langmuir. 2018 Jul 2. doi: 10.1021/acs.langmuir.8b00736. [Epub ahead of print]

PubMed ID: 29961336

Parkkila P, Elderdfi M, Bunker A, Viitala T. Biophysical Characterization of Supported Lipid Bilayers Using Parallel Dual-Wavelength Surface Plasmon Resonance and Quartz Crystal Microbalance Measurements. Langmuir. 2018 Jun 25. doi: 10.1021/acs.langmuir.8b01259. [Epub ahead of print]

PubMed ID: 29894192

Taylor GJ, Heberle FA, Seinfeld JS, Katsaras J, Collier CP , Sarles SA. Capacitive Detection of Low-Enthalpy, Higher-Order Phase Transitions in Synthetic and Natural Composition Lipid Membranes. Langmuir. 2017 Sep 26;33(38):10016-10026. doi: 10.1021/acs.langmuir.7b02022. Epub 2017 Sep 5.

PubMed ID: 28810118

Parkkila P, Elderdfi M, Bunker A, Viitala T. Biophysical Characterization of Supported Lipid Bilayers Using Parallel Dual-Wavelength Surface Plasmon Resonance and Quartz Crystal Microbalance Measurements. Langmuir. 2018 Jun 25. doi: 10.1021/acs.langmuir.8b01259. [Epub ahead of print]

PubMed ID: 29894192

Pittman AE, Marsh BP, King GM. Conformations and dynamic transitions of a melittin derivative that forms macromolecule-sized pores in lipid bilayers. Langmuir. 2018 Jun 22. doi: 10.1021/acs.langmuir.8b00804. [Epub ahead of print]

PubMed ID: 29933696

Ausili A, Martinez Valera P, Torrecillas A, Gómez-Murcia V, deGodos AM, Corbalan-Garcia S, Teruel JA, Gomez-Fernandez JC. The anticancer agent edelfosine exhibits a high affinity for cholesterol and disorganizes liquid ordered membrane structures. Langmuir. 2018 Jun 20. doi: 10.1021/acs.langmuir.8b01539. [Epub ahead of print]

PubMed ID: 29924618

Kot EF, Arseniev AS, Mineev KS. On the behavior of most widely spread lipids in isotropic bicelles. Langmuir. 2018 Jun 20. doi: 10.1021/acs.langmuir.8b01454. [Epub ahead of print]

PubMed ID: 29924628

Kumar S, Scheidt HA, Kaur N, Kaur A, Kang TS, Huster D, Mithu VS. Amphiphilic Ionic Liquid-Induced Membrane Permeabilization: Binding Is Not Enough. J Phys Chem B. 2018 Jun 20. doi: 10.1021/acs.jpcb.8b03733. [Epub ahead of print]

PubMed ID: 29878782

Parkkila P, Elderdfi M, Bunker A, Viitala T. Biophysical characterization of supported lipid bilayers using parallel dual-wavelength surface plasmon resonance and quartz crystal microbalance measurements. Langmuir. 2018 Jun 12. doi: 10.1021/acs.langmuir.8b01259. [Epub ahead of print]

PubMed ID: 29894192

Bhatia T, Agudo-Canalejo J, Dimova R, Lipowsky R. Membrane Nanotubes Increase the Robustness of Giant Vesicles. ACS Nano. 2018 Apr 16. doi: 10.1021/acsnano.8b00640.

PubMed ID: 29659246

Kulkarni JA, Darjuan MM, Mercer JE, Chen S, van der Meel R, Thewalt JL, Tam YYC, Cullis PR. Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA. ACS Nano. 2018 Apr 6. doi: 10.1021/acsnano.8b01516.

PubMed ID: 29614232

Blaschke BM, Böhm P, Drieschner S, Nickel B, Garrido JA. Lipid monolayer formation and lipid exchange monitored by a graphene field-effect transistor. Langmuir. 2018 Mar 15. doi: 10.1021/acs.langmuir.8b00162.

PubMed ID: 29542929

Gironi B, Paolantoni M, Morresi A, Foggi P1, Sassi P. Influence of Dimethyl Sulfoxide on the Low-Temperature Behavior of Cholesterol-Loaded Palmitoyl-oleyl-phosphatidylcholine Membranes. J Phys Chem B. 2018 Jun 7. doi: 10.1021/acs.jpcb.8b02333. [Epub ahead of print]

PubMed ID: 29847732

Zong W, Thingholm B, Itel F, Schattling PS, Brodszkij E, Mayer D, Stenger S, Goldie KN, Han X, Städler B. Phospholipid-Block Copolymer Hybrid Vesicles with Lysosomal Escape Ability. Langmuir. 2018 Jun 1. doi: 10.1021/acs.langmuir.8b01073. [Epub ahead of print]

PubMed ID: 29776311

Skyttner C, Enander K, Aronsson C, Aili D. Tuning Liposome Membrane Permeability by Competitive Coiled Coil Heterodimerization and Heterodimer Exchange. Langmuir. 2018 May 22. doi: 10.1021/acs.langmuir.8b00592. [Epub ahead of print]

PubMed ID: 29758162

James Kurniawan, João Ventrici, Gregory Kittleson and Tonya L. Kuhl Interaction Forces between Lipid Rafts. Langmuir. Publication Date (Web): December 21, 2016 DOI: 10.1021/acs.langmuir.6b03717

PubMed ID: 28001077

What Is the Preferred Conformation of Phosphatidylserine–Copper(II) Complexes? A Combined Theoretical and Experimental Investigation Kari Kusler, Samuel O. Odoh, Alexey Silakov, Matthew F. Poyton, Saranya Pullanchery, Paul S. Cremer and Laura Gagliardi J. Phys. Chem. B, Article ASAP DOI: 10.1021/acs.jpcb.6b10675

PubMed ID: 27957849

Nuria Roldan,Thomas K.M. Nyholm,J. Peter Slotte,Jesús Pérez-Gil,Begoña García-Álvarez. (2016). Effect of Lung Surfactant Protein SP-C and SP-C-Promoted Membrane Fragmentation on Cholesterol Dynamics. Biophysical Journal 111(8):1703-1713.

PubMed ID: 27760357

Victor, K.G., J.P. Korb, and R.G. Bryant. (2013). Translational Dynamics of Water at the Phospholipid Interface. J Phys Chem B Sep 23, 2013

PubMed ID: 24059874

Acyl Chain Length and Saturation Modulate Interleaflet Coupling in Asymmetric Bilayers: Effects on Dynamics and Structural Order. Salvatore Chiantia and Erwin London, Biophysical Journal, Volume 103, Issue 11, 2311-2319, 5 December 2012.

PubMed ID: 23283230

Jerabek, H., G. Pabst, M. Rappolt, and T. Stockner. (2010). Membrane-mediated effect on ion channels induced by the anesthetic drug ketamine. J Am Chem Soc 132:7990-7.

PubMed ID: 20527936

Mark J. Richards and Susan Daniel, Two-Phase Contiguous Supported Lipid Bilayer Model for Membrane Rafts via Polymer Blotting and Stenciling, Langmuir, Article ASAP DOI: 10.1021/acs.langmuir.6b04385

PubMed ID: 28092950

Shin, Y.K. and W.L. Hubbell. (1992). Determination of electrostatic potentials at biological interfaces using electron-electron double resonance. Biophys J 61:1443-53.

PubMed ID: 1319760

James Kruczek, See-Wing Chiu, Eric Jakobsson and Sagar A. Pandit, Effects of Lithium and Other Monovalent Ions on Palmitoyl Oleoyl Phosphatidylcholine Bilayer, Langmuir, Article ASAP DOI: 10.1021/acs.langmuir.6b04166

PubMed ID: 28076953

Nanoroughness Strongly Impacts Lipid Mobility in Supported Membranes Florence Blachon†, Frédéric Harb‡, Bogdan Munteanu§, Agnès Piednoir†, Rémy Fulcrand†, Thierry Charitat∥, Giovanna Fragneto⊥, Olivier Pierre-Louis†, Bernard Tinland#, and Jean-Paul Rieu*† Langmuir, Article ASAP

PubMed ID: 28219008

Charles G. Cranfield, Sónia Troeira Henriques, Boris Martinac, Paul Duckworth, David J. Craik and Bruce Cornell. Kalata B1 and Kalata B2 Have a Surfactant-Like Activity in Phosphatidylethanolomine-Containing Lipid Membranes. Langmuir, Article ASAP

PubMed ID: 28605904

Ling Han, Luis C. Morales, Michele R. Richards, Elena N. Kitova, Simonetta Sipione and John S. Klassen. Investigating the Influence of Membrane Composition on Protein–Glycolipid Binding Using Nanodiscs and Proxy Ligand Electrospray Ionization Mass Spectrometry. Anal. Chem., Article ASAP

PubMed ID: 28768095

Yixing Chen, Halil I. Okur, Cornelis Lütgebaucks, and Sylvie Roke. Zwitterionic and charged lipids form remarkably different structures on nanoscale oil droplets in aqueous solution. Langmuir, Just Accepted Manuscript.

PubMed ID: 29019694

Saba Ghazvini, Ryan Alonso, Nabil Alhakamy, and Prajnaparamita Dhar. pH induced changes in the surface viscosity of unsaturated phospholipids monitored using active interfacial microrheology. Langmuir, Just Accepted Manuscript

PubMed ID: 29019691

Maria J. Sarmento, Ana Coutinho, Aleksander Fedorov, Manuel Prieto, and Fabio Fernandes. Membrane Order Is a Key Regulator of Divalent Cation-Induced Clustering of PI(3,5)P2 and PI(4,5)P2. Langmuir. Article ASAP.

PubMed ID: 28961003

Masato Abe, Yoshiki Sawada, Shinpei Uno, Shuhei Chigasaki, Masahide Oku, Yasuyoshi Sakai, and Hideto Miyoshi. Role of Acyl Chain Composition of Phosphatidylcholine in Tafazzin-Mediated Remodeling of Cardiolipin in Liposomes. Biochemistry, Article ASAP

PubMed ID: 29091407

Sunami T, Shimada K, Tsuji G, Fujii S Flow Cytometric Analysis To Evaluate Morphological Changes in Giant Liposomes As Observed in Electrofusion Experiments. Langmuir. 2017 Dec 19. doi: 10.1021/acs.langmuir.7b03317.

PubMed ID: 29215888

Matsufuji T, Kinoshita M, Möuts A, Slotte JP, Matsumori N Preparation and Membrane Properties of Oxidized Ceramide Derivatives. Langmuir. 2017 Dec 27. doi: 10.1021/acs.langmuir.7b02654.

PubMed ID: 29231736

Mumtaz Virk M, Reimhult E. Phospholipase A2-Induced Degradation and Release from Lipid-Containing Polymersomes. Langmuir. 2017 Dec 27. doi: 10.1021/acs.langmuir.7b03893.

PubMed ID: 29231739

Enrico Forbrig, Jana K. Staffa, Johannes Salewski, Maria Andrea Mroginski, Peter Hildebrandt, and Jacek Kozuch. Monitoring the Orientational Changes of Alamethicin Incorporating into Bilayer Lipid Membranes. Langmuir, Just Accepted Manuscript DOI: 10.1021/acs.langmuir.7b04265

PubMed ID: 29353482

Enoki TA, Moreira-Silva I, Lorenzon EN, Cilli EM, Perez KR, Riske KA, Lamy MT. Antimicrobial Peptide K0-W6-Hya1 Induces Stable Structurally Modified Lipid Domains in Anionic Membranes. Langmuir. 2018 Jan 22. doi: 10.1021/acs.langmuir.7b03408. [Epub ahead of print]

PubMed ID: 29284086

Forbrig E, Staffa JK, Salewski J, Mroginski MA, Hildebrandt P, Kozuch J. Monitoring the Orientational Changes of Alamethicin during Incorporation into Bilayer Lipid Membranes. Langmuir. 2018 Feb 1. doi: 10.1021/acs.langmuir.7b04265. [Epub ahead of print]

PubMed ID: 29353482

Markones M, Drechsler C, Kaiser M, Kalie L, Heerklotz H, Fiedler S. Engineering Asymmetric Lipid Vesicles: Accurate and Convenient Control of the Outer Leaflet Lipid Composition. Langmuir. 2018 Jan 29. doi: 10.1021/acs.langmuir.7b03189. [Epub ahead of print]

PubMed ID: 29294294

Okano T, Inoue K, Koseki K, Suzuki H. Deformation Modes of Giant Unilamellar Vesicles Encapsulating Biopolymers. ACS Synth Biol. 2018 Feb 5. doi: 10.1021/acssynbio.7b00460. [Epub ahead of print]

PubMed ID: 29382193

Li G, Kim J, Huang Z, St Clair JR, Brown DA, London E. Efficient replacement of plasma membrane outer leaflet phospholipids and sphingolipids in cells with exogenous lipids. Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14025-14030. Epub 2016 Nov 21.

PubMed ID: 27872310

Bockelmann S, Mina JGM, Korneev S, Hassan DG, Mueller D, Hilderink A, Vlieg HC, Raijmakers R, Heck AJR, Haberkant P, Holthuis JCM. A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7. J Lipid Res. 2018 Jan 17. pii: jlr.M082354. doi: 10.1194/jlr.M082354.

PubMed ID: 29343537

Ausili A, Torrecillas A, deGodos AM, Corbalan-Garcia S, Gomez-Fernandez JC. The phenolic group of α-tocopherol anchors in the lipid-water interface of fully saturated membranes. Langmuir. 2018 Feb 15. doi: 10.1021/acs.langmuir.7b04142. [Epub ahead of print]

PubMed ID: 29447442

Kot EF, Goncharuk SA, Arseniev AS, Mineev KS. Phase Transitions in Small Isotropic Bicelles. Langmuir. 2018 Mar 6. doi: 10.1021/acs.langmuir.7b03610.

PubMed ID: 29486112

Peñalva DA, Antollini S, Ambroggio E, Aveldaño MI, Fanani ML. MEMBRANE RESTRUCTURING EVENTS DURING THE ENZYMATIC GENERATION OF CERAMIDES WITH VERY LONG-CHAIN POLYUNSATURATED FATTY ACIDS. Langmuir. 2018 Mar 15. doi: 10.1021/acs.langmuir.7b04374. [Epub ahead of print]

PubMed ID: 29540057