850457 | 16:0-18:1 PC (POPC)

1-palmitoyl-2-oleoyl-glycero-3-phosphocholine

Chloroform

Size SKU Packaging Price
25mg 850457C-25mg 850457C-25mg 1 x 25mg 10mg/mL 2.5mL $89.75
200mg 850457C-200mg 850457C-200mg 2 x 100mg 25mg/mL 4mL $234.00
500mg 850457C-500mg 850457C-500mg 5 x 100mg 25mg/mL 4mL $415.00
1g 850457C-1g 850457C-1g 2 x 500mg 25mg/mL 20mL $594.00

Powder

Size SKU Packaging Price
25mg 850457P-25mg 850457P-25mg 1 x 25mg $89.75
200mg 850457P-200mg 850457P-200mg 2 x 100mg $234.00
500mg 850457P-500mg 850457P-500mg 5 x 100mg $415.00
1g 850457P-1g 850457P-1g 1 x 1g $594.00
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16:0-18:1 PC (POPC)

16:0-18:1 PC (POPC)

1-palmitoyl-2-oleoyl-glycero-3-phosphocholine

POPC is typically considered one of the model lipids for biophysical experiments. The fatty acid composition, i.e., saturated chain in the sn-1 position and unsaturated chain in the sn-2 position, mimics mammalian phospholipid composition. Since the major constituent in Egg PC is 1-palmitoyl-2-oleoyl PC, POPC is an excellent synthetic substitute for EPC.

Hygroscopic
Yes
Light Sensitive
No
Molecular Formula
C42H82NO8P
Percent Composition
C 66.37%, H 10.87%, N 1.84%, O 16.84%, P 4.08%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
26853-31-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
760.076
Exact Mass
759.578
Synonyms
1-hexadecanoyl-2--(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
POPC
PC(16:0/18:1(9Z))

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Paananen RO, Viitaja T, Olżyńska A, Ekholm FS, Moilanen J, Cwiklik L. Interactions of polar lipids with cholesteryl ester multilayers elucidate tear film lipid layer structure. Ocul Surf. 2020 Jun 17:S1542-0124(20)30098-7. doi: 10.1016/j.jtos.2020.06.001. Epub ahead of print. PMID: 32562857.

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Cörek E, Rodgers G, Siegrist S, Einfalt T, Detampel P, Schlepütz CM, Sieber S, Fluder P, Schulz G, Unterweger H, Alexiou C, Müller B, Puchkov M, Huwyler J. Shedding Light on Metal-Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution. Small. 2020 Jun 22:e2000746. doi: 10.1002/smll.202000746. Epub ahead of print. PMID: 32567135.

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Wetzel L, Blanchard S, Rama S, Beier V, Kaufmann A, Wollert T. TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes. Nat Commun. 2020 Jun 12;11(1):2993. doi: 10.1038/s41467-020-16689-5. PMID: 32532970; PMCID: PMC7293217.

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Hauseman ZJ, Harvey EP, Newman CE, Wales TE, Bucci JC, Mintseris J, Schweppe DK, David L, Fan L, Cohen DT, Herce HD, Mourtada R, Ben-Nun Y, Bloch NB, Hansen SB, Wu H, Gygi SP, Engen JR, Walensky LD. Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization. Mol Cell. 2020 Jul 2;79(1):68-83.e7. doi: 10.1016/j.molcel.2020.05.029. Epub 2020 Jun 12. PMID: 32533918.

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Alexander TE, Smith IM, Lipsky ZW, Lozeau LD, Camesano TA. Role of lipopolysaccharides and lipoteichoic acids on C-Chrysophsin-1 interactions with model Gram-positive and Gram-negative bacterial membranes. Biointerphases. 2020 May 26;15(3):031007. doi: 10.1116/1.5130774. PMID: 32456440.

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Martins DB, Pacca CC, da Silva AMB, de Souza BM, de Almeida MTG, Palma MS, Arcisio-Miranda M, Dos Santos Cabrera MP. Comparing activity, toxicity and model membrane interactions of Jelleine-I and Trp/Arg analogs: analysis of peptide aggregation. Amino Acids. 2020 May;52(5):725-741. doi: 10.1007/s00726-020-02847-y. Epub 2020 May 4. PMID: 32367434.

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Rottet S, Iqbal S, Beales PA, Lin A, Lee J, Rug M, Scott C, Callaghan R. Characterisation of Hybrid Polymersome Vesicles Containing the Efflux Pumps NaAtm1 or P-Glycoprotein. Polymers (Basel). 2020 May 3;12(5):1049. doi: 10.3390/polym12051049. PMID: 32375237; PMCID: PMC7284524.

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Caviglia C, Garbarino F, Canali C, Melander F, Raiteri R, Ferrari G, Sampietro M, Heiskanen A, Andresen TL, Zór K, Emnéus J. Monitoring cell endocytosis of liposomes by real-time electrical impedance spectroscopy. Anal Bioanal Chem. 2020 May 25. doi: 10.1007/s00216-020-02592-x. Epub ahead of print. PMID: 32451643.

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Dey S, Das A, Dey A, Maiti S. Membrane affinity of individual toxic protein oligomers determined at the single-molecule level. Phys Chem Chem Phys. 2020 Jun 2. doi: 10.1039/d0cp00450b. Epub ahead of print. PMID: 32483579.

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Roussel G, White SH. The SecA ATPase motor protein binds to Escherichia coli liposomes only as monomers. Biochim Biophys Acta Biomembr. 2020 Sep 1;1862(9):183358. doi: 10.1016/j.bbamem.2020.183358. Epub 2020 May 19. PMID: 32416191.

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de Oliveira C, Khatua B, El-Kurdi B, Patel K, Mishra V, Navina S, Grim BJ, Gupta S, Belohlavek M, Cherry B, Yarger J, Green MD, Singh VP. Thermodynamic interference with bile acid demicelleization reduces systemic entry and injury during cholestasis. Sci Rep. 2020 May 21;10(1):8462. doi: 10.1038/s41598-020-65451-w. PMID: 32439972; PMCID: PMC7242474.

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Trapani G, Caruso VCL, Cucci LM, Attanasio F, Tabbì G, Forte G, La Mendola D, Satriano C. Graphene Oxide Nanosheets Tailored With Aromatic Dipeptide Nanoassemblies for a Tuneable Interaction With Cell Membranes. Front Bioeng Biotechnol. 2020 May 8;8:427. doi: 10.3389/fbioe.2020.00427. PMID: 32457892; PMCID: PMC7227426.

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Matos ALL, Kudruk S, Moratz J, Heflik M, Grill D, Ravoo BJ, Gerke V. Membrane Binding Promotes Annexin A2 Oligomerization. Cells. 2020 May 8;9(5):1169. doi: 10.3390/cells9051169. PMID: 32397265; PMCID: PMC7291239.

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Hu XY, Gao J, Chen FY, Guo DS. A host-guest drug delivery nanosystem for supramolecular chemotherapy. J Control Release. 2020 May 8;324:124-133. doi: 10.1016/j.jconrel.2020.05.008. Epub ahead of print. PMID: 32430277.

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Xu X, Hou B, Fulzele A, Masubuchi T, Zhao Y, Wu Z, Hu Y, Jiang Y, Ma Y, Wang H, Bennett EJ, Fu G, Hui E. PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2. J Cell Biol. 2020 Jun 1;219(6):e201905085. doi: 10.1083/jcb.201905085. PMID: 32437509; PMCID: PMC7265324.

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Gault J, Liko I, Landreh M, Shutin D, Bolla JR, Jefferies D, Agasid M, Yen HY, Ladds MJGW, Lane DP, Khalid S, Mullen C, Remes PM, Huguet R, McAlister G, Goodwin M, Viner R, Syka JEP, Robinson CV. Combining native and 'omics' mass spectrometry to identify endogenous ligands bound to membrane proteins. Nat Methods. 2020 May;17(5):505-508. doi: 10.1038/s41592-020-0821-0. Epub 2020 May 4. PMID: 32371966.

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Phan MD, Lee KY, Lee J, Satija SK, Shin K. The Effect of Cholesterol on Membrane Binding and Self-Assembly of Collagen Fibrils. Langmuir. 2020 May 27. doi: 10.1021/acs.langmuir.0c00574. Epub ahead of print. PMID: 32460498.

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Liu KN, Boxer SG. Target Membrane Cholesterol Modulates Single Influenza Virus Membrane Fusion Efficiency but Not Rate. Biophys J. 2020 May 19;118(10):2426-2433. doi: 10.1016/j.bpj.2020.03.021. Epub 2020 Apr 4. PMID: 32298636; PMCID: PMC7231891.

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Yamamoto A, Tsukamoto T, Suzuki K, Hashimoto E, Kobashigawa Y, Shibasaki K, Uchida T, Inagaki F, Demura M, Ishimori K. Spectroscopic Characterization of Halorhodopsin Reconstituted into Nanodisks Using Native Lipids. Biophys J. 2020 Apr 29:S0006-3495(20)30344-1. doi: 10.1016/j.bpj.2020.04.021. Epub ahead of print. PMID: 32396848.

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Li M, Heller WT, Liu CH, Gao CY, Cai Y, Hou Y, Nieh MP. Effects of fluidity and charge density on the morphology of a bicellar mixture - A SANS study. Biochim Biophys Acta Biomembr. 2020 Apr 15;1862(9):183315. doi: 10.1016/j.bbamem.2020.183315. Epub ahead of print. PMID: 32304755.

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Zimbone S, Santoro AM, La Mendola D, Giacomelli C, Trincavelli ML, Tomasello MF, Milardi D, García-Viñuales S, Sciacca MFM, Martini C, Grasso G. The Ionophoric Activity of a Pro-Apoptotic VEGF165 Fragment on HUVEC Cells. Int J Mol Sci. 2020 Apr 20;21(8):2866. doi: 10.3390/ijms21082866. PMID: 32325956; PMCID: PMC7216235.

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Lee H, Jiang D, Pardridge WM. Lyoprotectant Optimization for the Freeze-Drying of Receptor-Targeted Trojan Horse Liposomes for Plasmid DNA Delivery. Mol Pharm. 2020 Apr 29. doi: 10.1021/acs.molpharmaceut.0c00310. Epub ahead of print. PMID: 32315188.

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Koseki K, Suzuki H. Deformation Dynamics of Giant Unilamellar Vesicles in the Large Surface-to-Volume Ratio Regime: The Emergence of Neuron-like Morphology. Langmuir. 2020 May 18. doi: 10.1021/acs.langmuir.0c00872. Epub ahead of print. PMID: 32364747.

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Sun J, Singaram I, Soflaee MH, Cho W. A Direct Fluorometric Activity Assay for Lipid Kinases and Phosphatases. J Lipid Res. 2020 Apr 27:jlr.D120000794. doi: 10.1194/jlr.D120000794. Epub ahead of print. PMID: 32341006.

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Cholak E, Bugge K, Khondker A, Gauger K, Pedraz-Cuesta E, Pedersen ME, Bucciarelli S, Vestergaard B, Pedersen SF, Rheinstädter MC, Langkilde AE, Kragelund BB. Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion. FASEB J. 2020 Apr 11. doi: 10.1096/fj.202000107R. Epub ahead of print. PMID: 32277854.

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Gozem S, Johnson PJM, Halpin A, Luk HL, Morizumi T, Prokhorenko VI, Ernst OP, Olivucci M, Miller RJD. Excited-State Vibronic Dynamics of Bacteriorhodopsin from Two-Dimensional Electronic Photon Echo Spectroscopy and Multiconfigurational Quantum Chemistry. J Phys Chem Lett. 2020 May 4:3889-3896. doi: 10.1021/acs.jpclett.0c01063. Epub ahead of print. PMID: 32330041.

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Roy D, Steinkühler J, Zhao Z, Lipowsky R, Dimova R. Mechanical Tension of Biomembranes Can Be Measured by Super Resolution (STED) Microscopy of Force-Induced Nanotubes. Nano Lett. 2020 May 13;20(5):3185-3191. doi: 10.1021/acs.nanolett.9b05232. Epub 2020 Apr 29. PMID: 32320255.

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Santos TCB, Vaz A, Ventura AE, M Saied E, Arenz C, Fedorov A, Prieto M, Silva LC. Canonical and 1-Deoxy(methyl) Sphingoid Bases: Tackling the Effect of the Lipid Structure on Membrane Biophysical Properties. Langmuir. 2020 May 15. doi: 10.1021/acs.langmuir.0c01000. Epub ahead of print. PMID: 32369370.

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Maravilla E, Le DP, Tran JJ, Chiu MH, Prenner EJ, Weers PMM. Apolipophorin III interaction with phosphatidylglycerol and lipopolysaccharide: A potential mechanism for antimicrobial activity. Chem Phys Lipids. 2020 Mar 21;229:104909. doi: 10.1016/j.chemphyslip.2020.104909. Epub ahead of print. PMID: 32209325.

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Zhang W, Metzger JM, Hackel BJ, Bates FS, Lodge TP. Influence of the Headgroup on the Interaction of Poly(ethylene oxide)-Poly(propylene oxide) Block Copolymers with Lipid Bilayers. J Phys Chem B. 2020 Mar 26;124(12):2417-2424. doi: 10.1021/acs.jpcb.0c00553. Epub 2020 Mar 16. PMID: 32175743.

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Passos Gibson V, Fauquignon M, Ibarboure E, Leblond Chain J, Le Meins JF. Switchable Lipid Provides pH-Sensitive Properties to Lipid and Hybrid Polymer/Lipid Membranes. Polymers (Basel). 2020 Mar 11;12(3):E637. doi: 10.3390/polym12030637. PMID: 32168824.

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Pham QD, Carlström G, Lafon O, Sparr E, Topgaard D. Quantification of the amount of mobile components in intact stratum corneum with natural-abundance 13C solid-state NMR. Phys Chem Chem Phys. 2020 Mar 25;22(12):6572-6583. doi: 10.1039/d0cp00079e. PMID: 32159206.

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Škerle J, Humpolíčková J, Johnson N, Rampírová P, Poláchová E, Fliegl M, Dohnálek J, Suchánková A, Jakubec D, Strisovsky K. Membrane Protein Dimerization in Cell-Derived Lipid Membranes Measured by FRET with MC Simulations. Biophys J. 2020 Apr 21;118(8):1861-1875. doi: 10.1016/j.bpj.2020.03.011. Epub 2020 Mar 29. PMID: 32246901; PMCID: PMC7175701.

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Josey BP, Heinrich F, Silin V, Lösche M. Association of Model Neurotransmitters with Lipid Bilayer Membranes. Biophys J. 2020 Mar 10;118(5):1044-1057. doi: 10.1016/j.bpj.2020.01.016. Epub 2020 Jan 28. PMID: 32032504; PMCID: PMC7063487.

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Malabed R, Hanashima S, Murata M, Sakurai K. Interactions of OSW-1 with Lipid Bilayers in Comparison with Digitonin and Soyasaponin. Langmuir. 2020 Apr 7;36(13):3600-3610. doi: 10.1021/acs.langmuir.9b03957. Epub 2020 Mar 30. PMID: 32160747.

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Bryce DA, Kitt JP, Myres GJ, Harris JM. Confocal Raman Microscopy Investigation of Phospholipid Monolayers Deposited on Nitrile-Modified Surfaces in Porous Silica Particles. Langmuir. 2020 Apr 21;36(15):4071-4079. doi: 10.1021/acs.langmuir.0c00456. Epub 2020 Apr 7. PMID: 32212663.

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Kim M, Heinrich F, Haugstad G, Yu G, Yuan G, Satija SK, Zhang W, Seo HS, Metzger JM, Azarin SM, Lodge TP, Hackel BJ, Bates FS. Spatial Distribution of PEO-PPO-PEO Block Copolymer and PEO Homopolymer in Lipid Bilayers. Langmuir. 2020 Apr 7;36(13):3393-3403. doi: 10.1021/acs.langmuir.9b03208. Epub 2020 Mar 27. PMID: 32216370.

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Olżyńska A, Wizert A, Štefl M, Iskander DR, Cwiklik L. Mixed polar-nonpolar lipid films as minimalistic models of Tear Film Lipid Layer: A Langmuir trough and fluorescence microscopy study. Biochim Biophys Acta Biomembr. 2020 Mar 31;1862(9):183300. doi: 10.1016/j.bbamem.2020.183300. Epub ahead of print. PMID: 32243884.

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Raheem N, Kumar P, Lee E, Cheng JTJ, Hancock REW, Straus SK. Insights into the mechanism of action of two analogues of aurein 2.2. Biochim Biophys Acta Biomembr. 2020 Jun 1;1862(6):183262. doi: 10.1016/j.bbamem.2020.183262. Epub 2020 Mar 5. PMID: 32147356.

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Faraj BHA, Collard L, Cliffe R, Blount LA, Lonnen R, Wallis R, Andrew PW, Hudson AJ. Formation of pre-pore complexes of pneumolysin is accompanied by a decrease in short-range order of lipid molecules throughout vesicle bilayers. Sci Rep. 2020 Mar 12;10(1):4585. doi: 10.1038/s41598-020-60348-0. PMID: 32165654; PMCID: PMC7067851.

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