850356 | 4ME 16:0 PC

1,2-diphytanoyl-sn-glycero-3-phosphocholine


Chloroform

Size SKU Packaging Price
25mg 850356C-25mg 850356C-25mg 1 x 25mg 10mg/mL 2.5mL $113.50
200mg 850356C-200mg 850356C-200mg 2 x 100mg 25mg/mL 4mL $360.00
500mg 850356C-500mg 850356C-500mg 1 x 500mg 25mg/mL 20mL $765.00

Powder

Size SKU Packaging Price
25mg 850356P-25mg 850356P-25mg 1 x 25mg $113.50
200mg 850356P-200mg 850356P-200mg 1 x 200mg $360.00
500mg 850356P-500mg 850356P-500mg 1 x 500mg $765.00
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4ME 16:0 PC

4ME 16:0 PC

1,2-diphytanoyl-sn-glycero-3-phosphocholine

Lipids containing diphytanoyl fatty acid chains have been used to produce stable planar lipid membranes (see References). Diphytanoyl phosphatidylcholine does not exhibit a detectable gel to liquid crystalline phase transition from -120°C to +120°C.

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC's. All of the products are purified by HPLC, and special precautions are taken to protect the products from oxidization and hydrolysis. Several of these products are manufactured under the current guidelines of Good Manufacturing Practice and are available for pharmaceutical use. If you have a requirement for a choline derivative not found on our list, please call us: custom synthesis is one of our specialties.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C48H96NO8P
Percent Composition
C 68.13%, H 11.43%, N 1.66%, O 15.12%, P 3.66%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
207131-40-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
846.252
Exact Mass
845.687
Synonyms
<p>1,2-di-(3,7,11,15-tetramethylhexadecanoyl)-sn-glycero-3-phosphocholinePC(16:0(3me,7me,11me,15me)/16:0(3me,7me,11me,15me))</p>

Willems K, Ruić D, Biesemans A, Galenkamp NS, Van Dorpe P, Maglia G. Engineering and Modeling the Electrophoretic Trapping of a Single Protein Inside a Nanopore. ACS Nano. 2019 Aug 20. doi: 10.1021/acsnano.8b09137. [Epub ahead of print]

PubMed ID: 31403770

Wang H, Kasianowicz JJ, Robertson JWF, Poster DL, Ettedgui J. A comparison of ion channel current blockades caused by individual poly(ethylene glycol) molecules and polyoxometalate nanoclusters. Eur Phys J E Soft Matter. 2019 Jun 28;42(6):83. doi: 10.1140/epje/i2019-11838-3.

PubMed ID: 31250227

Baxter AM, Wittenberg NJ. Excitation of Fluorescent Lipid Probes Accelerates Supported Lipid Bilayer Formation via Photosensitized Lipid Oxidation. Langmuir. 2019 Sep 3;35(35):11542-11549. doi: 10.1021/acs.langmuir.9b01535. Epub 2019 Aug 22.

PubMed ID: 31411482

Hui Li, Shaoying Wang, Zhouxiang Ji, Congcong Xu, Lyudmila S. Shlyakhtenko, Peixuan Guo. Construction of RNA nanotubes. August 2019;8:1952-1958.


Megalathan A, Cox BD, Wilkerson PD, Kaur A, Sapkota K, Reiner JE, Dhakal S. Single-molecule analysis of i-motif within self-assembled DNA duplexes and nanocircles. Nucleic Acids Res. 2019 Jul 9. pii: gkz565. doi: 10.1093/nar/gkz565. [Epub ahead of print]

PubMed ID: 31287873

Su Z, Ho D, Merrill AR, Lipkowski J. In Situ Electrochemical and PM-IRRAS Studies of Colicin E1 Ion Channels in the Floating Bilayer Lipid Membrane. Langmuir. 2019 Jun 25;35(25):8452-8459. doi: 10.1021/acs.langmuir.9b01251. Epub 2019 Jun 13.

PubMed ID: 31194562

Liu YM, Fang XY, Fang F, Wu ZY. Investigation of hairpin DNA and chelerythrine interaction by a single bio-nanopore sensing interface. Analyst. 2019 Jul 7;144(13):4081-4085. doi: 10.1039/c9an00113a. Epub 2019 Jun 6.

PubMed ID: 31169284

Liu L, Fang Z, Zheng X, Xi D. Nanopore-Based Strategy for Sensing of Copper(II) Ion and Real-Time Monitoring of a Click Reaction. ACS Sens. 2019 May 24;4(5):1323-1328. doi: 10.1021/acssensors.9b00236. Epub 2019 May 10.

PubMed ID: 31050287

Tan S, Zhang L, Yu L, Xu L. Free-Standing Lipid Bilayers Based on Nanopore Array and Ion Channel Formation. J Nanosci Nanotechnol. 2019 Nov 1;19(11):7149-7155. doi: 10.1166/jnn.2019.16674.

PubMed ID: 31039869

Janilson J. S. Júnior, Thereza A. Soares, Laércio Pol-Fachin, Dijanah C. Machado, Victor H. Rusu, Juliana P. Aguiar, and Cláudio G. Rodrigues. Alpha-hemolysin nanopore allows discrimination of the microcystins variants. (Paper) RSC Adv., 2019, 9, 14683-14691. doi: 10.1039/C8RA10384D


Santos HJ, Imai K, Makiuchi T, Tomii K, Horton P, Nozawa A, Okada K, Tozawa Y, Nozaki T. Novel lineage-specific transmembrane β-barrel proteins in the endoplasmic reticulum of Entamoeba histolytica. FEBS J. 2019 May 2. doi: 10.1111/febs.14870. [Epub ahead of print]

PubMed ID: 31070654

Lee MT, Hung WC, Huang HW. Rhombohedral trap for studying molecular oligomerization in membranes: application to daptomycin. Soft Matter. 2019 May 29;15(21):4326-4333. doi: 10.1039/c9sm00323a.

PubMed ID: 31070654

Puthumadathil N, Jayasree P, Santhosh Kumar K, Nampoothiri KM, Bajaj H, Mahendran KR. Detecting the structural assembly pathway of human antimicrobial peptide pores at single-channel level. Biomater Sci. 2019 Jun 5. doi: 10.1039/c9bm00181f. [Epub ahead of print]

PubMed ID: 31165117

Vu T, Borgesi J, Soyring J, D'Alia M, Davidson SL, Shim J. Employing LiCl salt gradient in the wild-type α-hemolysin nanopore to slow down DNA translocation and detect methylated cytosine. Nanoscale. 2019 May 30;11(21):10536-10545. doi: 10.1039/c9nr00502a.

PubMed ID: 31116213

Ji Z, Guo P. Channel from bacterial virus T7 DNA packaging motor for the differentiation of peptides composed of a mixture of acidic and basic amino acids. Biomaterials. 2019 Sep;214:119222. doi: 10.1016/j.biomaterials.2019.119222. Epub 2019 May 21.

PubMed ID: 31158604

Wang K, Preisler SS, Zhang L, Cui Y, Missel JW, Grønberg C, Gotfryd K, Lindahl E, Andersson M, Calloe K, Egea PF, Klaerke DA, Pusch M, Pedersen PA, Zhou ZH, Gourdon P. Structure of the human ClC-1 chloride channel. PLoS Biol. 2019 Apr 25;17(4):e3000218. doi: 10.1371/journal.pbio.3000218. eCollection 2019 Apr.

PubMed ID: 31022181

Larimi MG, Mayse LA, Movileanu L. Interactions of a Polypeptide with a Protein Nanopore Under Crowding Conditions. ACS Nano. 2019 Apr 23;13(4):4469-4477. doi: 10.1021/acsnano.9b00008. Epub 2019 Apr 3.

PubMed ID: 30925041

Noakes MT, Brinkerhoff H, Laszlo AH, Derrington IM, Langford KW, Mount JW, Bowman JL, Baker KS, Doering KM, Tickman BI, Gundlach JH. Increasing the accuracy of nanopore DNA sequencing using a time-varying cross membrane voltage. Nat Biotechnol. 2019 Apr 22. doi: 10.1038/s41587-019-0096-0. [Epub ahead of print]

PubMed ID: 31011178

Khoury ME, Winterstein T, Weber W, Stein V, Schlaak HF, Thiel G. Photolithographic Fabrication of Micro Apertures in Dry Film Polymer Sheets for Channel Recordings in Planar Lipid Bilayers. J Membr Biol. 2019 Mar 12. doi: 10.1007/s00232-019-00062-9. [Epub ahead of print]

PubMed ID: 30863900

Zhao Y, Liu L, Tu Y, Wu HC. Investigating the effect of mono- and multivalent counterions on the conformation of poly(styrenesulfonic acid) by nanopores. Electrophoresis. 2019 Feb 27. doi: 10.1002/elps.201800539. [Epub ahead of print]

PubMed ID: 30811621

Wang J, Fertig N, Ying YL. Real-time monitoring β-lactam/β-lactamase inhibitor (BL/BLI) mixture towards the bacteria porin pathway at single molecule level. Anal Bioanal Chem. 2019 Mar 2. doi: 10.1007/s00216-019-01650-3. [Epub ahead of print]

PubMed ID: 30824965

Golla VK, Sans-Serramitjana E, Pothula KR, Benier L, Bafna JA, Winterhalter M, Kleinekathöfer U. Fosfomycin Permeation through the Outer Membrane Porin OmpF. Biophys J. 2019 Jan 22;116(2):258-269. doi: 10.1016/j.bpj.2018.12.002. Epub 2018 Dec 8.

PubMed ID: 30616836

Coker HLE, Cheetham MR, Kattnig DR, Wang YJ, Garcia-Manyes S, Wallace MI. Controlling Anomalous Diffusion in Lipid Membranes. Biophys J. 2019 Mar 19;116(6):1085-1094. doi: 10.1016/j.bpj.2018.12.024. Epub 2019 Jan 16.

PubMed ID: 30846364

Zhang L, Wang K, Klaerke DA, Calloe K, Lowrey L, Pedersen PA, Gourdon P, Gotfryd K. Purification of Functional Human TRP Channels Recombinantly Produced in Yeast. Cells. 2019 Feb 11;8(2). pii: E148. doi: 10.3390/cells8020148.

PubMed ID: 30754715

Schönrock M, Thiel G, Laube B. Coupling of a viral K+-channel with a glutamate-binding-domain highlights the modular design of ionotropic glutamate-receptors. Commun Biol. 2019 Feb 22;2:75. doi: 10.1038/s42003-019-0320-y. eCollection 2019.

PubMed ID: 30820470

Inada M, Kinoshita M, Sumino A, Oiki S, Matsumori N. A concise method for quantitative analysis of interactions between lipids and membrane proteins. Anal Chim Acta. 2019 Jun 20;1059:103-112. doi: 10.1016/j.aca.2019.01.042. Epub 2019 Feb 1.

PubMed ID: 30876624

Huang G, Voet A, Maglia G. FraC nanopores with adjustable diameter identify the mass of opposite-charge peptides with 44 dalton resolution. Nat Commun. 2019 Feb 19;10(1):835. doi: 10.1038/s41467-019-08761-6.

PubMed ID: 30783102

Krishnan R S, Satheesan R, Puthumadathil N, Kumar KS, Jayasree P, Mahendran KR. Autonomously Assembled Synthetic Transmembrane Peptide Pore. J Am Chem Soc. 2019 Feb 20;141(7):2949-2959. doi: 10.1021/jacs.8b09973. Epub 2019 Feb 12.

PubMed ID: 30702873

Huang G, Voet A, Maglia G. FraC nanopores with adjustable diameter identify the mass of opposite-charge peptides with 44 dalton resolution. Nat Commun. 2019 Feb 19;10(1):835. doi: 10.1038/s41467-019-08761-6.

PubMed ID: 30783102

Krishnan R S, Satheesan R, Puthumadathil N, Kumar KS, Jayasree P, Mahendran KR. Autonomously Assembled Synthetic Transmembrane Peptide Pore. J Am Chem Soc. 2019 Feb 20;141(7):2949-2959. doi: 10.1021/jacs.8b09973. Epub 2019 Feb 12.

PubMed ID: 30702873

Dugger ME, Baker CA. Automated formation of black lipid membranes within a microfluidic device via confocal fluorescence feedback-controlled hydrostatic pressure manipulations. Anal Bioanal Chem. 2019 Jan 7. doi: 10.1007/s00216-018-1550-4. [Epub ahead of print]


PubMed ID: 30617393

Mohid SA, Ghorai A, Ilyas H, Mroue KH, Narayanan G, Sarkar A, Ray SK, Biswas K, Bera AK, Malmsten M, Midya A, Bhunia A. Application of tungsten disulfide quantum dot-conjugated antimicrobial peptides in bio-imaging and antimicrobial therapy. Colloids Surf B Biointerfaces. 2019 Jan 8;176:360-370. doi: 10.1016/j.colsurfb.2019.01.020. [Epub ahead of print]

PubMed ID: 30658284

Bhamidimarri SP, Zahn M, Prajapati JD, Schleberger C, Söderholm S, Hoover J, West J, Kleinekathöfer U, Bumann D, Winterhalter M, van den Berg B. A Multidisciplinary Approach toward Identification of Antibiotic Scaffolds for Acinetobacter baumannii. Structure. 2019 Feb 5;27(2):268-280.e6. doi: 10.1016/j.str.2018.10.021. Epub 2018 Dec 13.

PubMed ID: 30554842

Golla VK, Sans-Serramitjana E, Pothula KR, Benier L, Bafna JA, Winterhalter M, Kleinekathöfer U. Fosfomycin Permeation through the Outer Membrane Porin OmpF. Biophys J. 2019 Jan 22;116(2):258-269. doi: 10.1016/j.bpj.2018.12.002. Epub 2018 Dec 8.

PubMed ID: 30616836

Yang J, Wang Y, Li M, Ying YL, Long YT. Direct Sensing of Single Native RNA with a Single-Biomolecule Interface of Aerolysin Nanopore. Langmuir. 2018 Nov 21. doi: 10.1021/acs.langmuir.8b03264. [Epub ahead of print].

PubMed ID: 30462509

Chengxiang Zhang, Weiyu Zhao , Cong Bian, Xucheng Hou, Binbin Deng, David W. McComb, Xiaofang Chen, and Yizhou Dong. Antibiotic-Derived Lipid Nanoparticles to Treat Intracellular Staphylococcus aureus. ACS Appl. Bio Mater., Article ASAP


Challita EJ, Freeman EC. Hydrogel Microelectrodes for the Rapid, Reliable, and Repeatable Characterization of Lipid Membranes. Langmuir. 2018 Nov 23. doi: 10.1021/acs.langmuir.8b02867. [Epub ahead of print]

PubMed ID: 30468580

Patrick Urban, Stefanie D. Pritzl, David B. Konrad, James A. Frank, Carla Pernpeintner, Christian R. Roeske, Dirk Trauner, and Theobald Lohmueller. Light-Controlled Lipid Interaction and Membrane Organization in Photolipid Bilayer Vesicles. Langmuir, Just Accepted Manuscript. DOI: 10.1021/acs.langmuir.8b03241. Publication Date (Web): October 10, 2018

PubMed ID: 30346771

Sacconi A, Tadini-Buoninsegni F, Tiribilli B, Margheri G. A Comparative Study of Phosphatidylcholine versus Phosphatidylserine-based Solid Supported Membranes for the Preparation of Liposome-Rich Interfaces. Langmuir. 2018 Sep 14. doi: 10.1021/acs.langmuir.8b02397. [Epub ahead of print]

PubMed ID: 30217106

Burden DL, Kim D, Cheng W, Chandler Lawler E, Dreyer DR, Burden LK. Mechanically Enhancing Planar Lipid Bilayers with a Minimal Actin Cortex. Langmuir. 2018 Aug 27. doi: 10.1021/acs.langmuir.8b01847. [Epub ahead of print]

PubMed ID: 30149716

Beltramo PJ, Scheidegger L, Vermant J. Toward Realistic Large-Area Cell Membrane Mimics: Excluding Oil, Controlling Composition, and Including Ion Channels. Langmuir. 2018 May 14. doi: 10.1021/acs.langmuir.8b00837.

PubMed ID: 29715042

Lindsey, H., N.O. Petersen, and S.I. Chan. (1979). Physicochemical characterization of 1,2-diphytanoyl-sn-glycero-3-phosphocholine in model membrane systems. Biochim Biophys Acta 555:147-67. [PubMed]

PubMed ID: 476096

Villar, G., A.D. Graham, and H. Bayley. (2013). A tissue-like printed material. Science 340:48-52. [PubMed]

PubMed ID: 23559243

Pan, J., X. Cheng, F.A. Heberle, B. Mostofian, N. Kucerka, P. Drazba, and J. Katsaras. (2012). Interactions between Ether Phospholipids and Cholesterol As Determined by Scattering and Molecular Dynamics Simulations. J Phys Chem B [PubMed]

PubMed ID: 23199292

Tristram-Nagle, S., Kim, D.J., Akhunzada, N., Kucerka, N., Mathai, J.C., Katsaras, J., Zeidel, M., Nagle, J.F. (2010) Structure and water permeability of fully hydrated diphytanoylPC. Chem Phys Lipids.163:630-7. [PubMed]

PubMed ID: 20447383

Redwood, W.R., Pfeiffer, F.R., Weisbach, J.A., Thompson, T.E. (1971) Physical properties of bilayer membranes formed from a synthetic saturated phospholipid in n-decane. Biochim Biophys Acta.233:1-6. [PubMed]

PubMed ID: 5579131