850356 | 4ME 16:0 PC



Size SKU Packaging Price
25mg 850356C-25mg 850356C-25mg 1 x 25mg 10mg/mL 2.5mL $116.25
200mg 850356C-200mg 850356C-200mg 2 x 100mg 25mg/mL 4mL $370.00
500mg 850356C-500mg 850356C-500mg 1 x 500mg 25mg/mL 20mL $785.00


Size SKU Packaging Price
25mg 850356P-25mg 850356P-25mg 1 x 25mg $116.25
200mg 850356P-200mg 850356P-200mg 1 x 200mg $370.00
500mg 850356P-500mg 850356P-500mg 1 x 500mg $785.00
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4ME 16:0 PC

4ME 16:0 PC


Lipids containing diphytanoyl fatty acid chains have been used to produce stable planar lipid membranes (see References). Diphytanoyl phosphatidylcholine does not exhibit a detectable gel to liquid crystalline phase transition from -120°C to +120°C.

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC's. All of the products are purified by HPLC, and special precautions are taken to protect the products from oxidization and hydrolysis. Several of these products are manufactured under the current guidelines of Good Manufacturing Practice and are available for pharmaceutical use. If you have a requirement for a choline derivative not found on our list, please call us: custom synthesis is one of our specialties.

Light Sensitive
Molecular Formula
Percent Composition
C 68.13%, H 11.43%, N 1.66%, O 15.12%, P 3.66%
1 Years
Storage Temperature
CAS Number
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
Exact Mass

Das D, Bao H, Courtney KC, Wu L, Chapman ER. Resolving kinetic intermediates during the regulated assembly and disassembly of fusion pores. Nat Commun. 2020 Jan 13;11(1):231. doi: 10.1038/s41467-019-14072-7. PMID: 31932584; PMCID: PMC6957489.

PubMed ID: 31932584

Wang J, Li MY, Yang J, Wang YQ, Wu XY, Huang J, Ying YL, Long YT. Direct Quantification of Damaged Nucleotides in Oligonucleotides Using an Aerolysin Single Molecule Interface. ACS Cent Sci. 2020 Jan 22;6(1):76-82. doi: 10.1021/acscentsci.9b01129. Epub 2020 Jan 9. PMID: 31989027; PMCID: PMC6978832.

PubMed ID: 31989027

Vikraman D, Satheesan R, Kumar KS, Mahendran KR. Nanopore Passport Control for Substrate-Specific Translocation. ACS Nano. 2020 Jan 29:10.1021/acsnano.9b09408. doi: 10.1021/acsnano.9b09408. Epub ahead of print. PMID: 31976649.

PubMed ID: 31976649

Li J, Baxani DK, Jamieson WD, Xu W, Rocha VG, Barrow DA, Castell OK. Formation of Polarized, Functional Artificial Cells from Compartmentalized Droplet Networks and Nanomaterials, Using One-Step, Dual-Material 3D-Printed Microfluidics. Adv Sci (Weinh). 2019 Oct 24;7(1):1901719. doi: 10.1002/advs.201901719. PMID: 31921557; PMCID: PMC6947711.

PubMed ID: 31921557

Su Z, Juhaniewicz-Debinska J, Sek S, Lipkowski J. Water Structure in the Submembrane Region of a Floating Lipid Bilayer: The Effect of an Ion Channel Formation and the Channel Blocker. Langmuir. 2020 Jan 14;36(1):409-418. doi: 10.1021/acs.langmuir.9b03271. Epub 2019 Dec 23. PMID: 31815479.

PubMed ID: 31815479

Jiménez-Munguía I, Fedorov AK, Abdulaeva IA, Birin KP, Ermakov YA, Batishchev OV, Gorbunova YG, Sokolov VS. Lipid Membrane Adsorption Determines Photodynamic Efficiency of β-Imidazolyl-Substituted Porphyrins. Biomolecules. 2019 Dec 10;9(12):E853. doi: 10.3390/biom9120853. PMID: 31835568.

PubMed ID: 31835568

Fang Z, Liu L, Wang Y, Xi D, Zhang S. Unambiguous Discrimination of Multiple Protein Biomarkers by Nanopore Sensing with Double-Stranded DNA-Based Probes. Anal Chem. 2020 Jan 21;92(2):1730-1737. doi: 10.1021/acs.analchem.9b02965. Epub 2020 Jan 7. PMID: 31869203.

PubMed ID: 31869203

Snead WT, Zeno WF, Kago G, Perkins RW, Richter JB, Zhao C, Lafer EM, Stachowiak JC. BAR scaffolds drive membrane fission by crowding disordered domains. J Cell Biol. 2019 Feb 4;218(2):664-682. doi: 10.1083/jcb.201807119. Epub 2018 Nov 30. PMID: 30504247; PMCID: PMC6363457.

PubMed ID: 30504247

Cao J, Jia W, Zhang J, Xu X, Yan S, Wang Y, Zhang P, Chen HY, Huang S. Giant single molecule chemistry events observed from a tetrachloroaurate(III) embedded Mycobacterium smegmatis porin A nanopore. Nat Commun. 2019 Dec 11;10(1):5668. doi: 10.1038/s41467-019-13677-2.

PubMed ID: 31827098

Ouldali H, Sarthak K, Ensslen T, Piguet F, Manivet P, Pelta J, Behrends JC, Aksimentiev A, Oukhaled A. Electrical recognition of the twenty proteinogenic amino acids using an aerolysin nanopore. Nat Biotechnol. 2019 Dec 16. doi: 10.1038/s41587-019-0345-2. [Epub ahead of print]

PubMed ID: 31844293

Yamada T, Kamiya K, Osaki T, Takeuchi S. A pumpless solution exchange system for nanopore sensors. Biomicrofluidics. 2019 Nov 4;13(6):064104. doi: 10.1063/1.5123316. eCollection 2019 Nov.

PubMed ID: 31700563

Aminipour Z, Khorshid M, Keshvari H, Bonakdar S, Wagner P, Van der Bruggen B. Passive permeability assay of doxorubicin through model cell membranes under cancerous and normal membrane potential conditions. Eur J Pharm Biopharm. 2020 Jan;146:133-142. doi: 10.1016/j.ejpb.2019.10.011. Epub 2019 Nov 5.

PubMed ID: 31698041

Su Z, Wei Y, Kang XF. Simultaneous High-Resolution Detection of Bioenergetic Molecules using Biomimetic-Receptor Nanopore. Anal Chem. 2019 Dec 3;91(23):15255-15259. doi: 10.1021/acs.analchem.9b04268. Epub 2019 Nov 11.

PubMed ID: 31665602

Cao C, Cirauqui N, Marcaida MJ, Buglakova E, Duperrex A, Radenovic A, Dal Peraro M. Single-molecule sensing of peptides and nucleic acids by engineered aerolysin nanopores. Nat Commun. 2019 Oct 29;10(1):4918. doi: 10.1038/s41467-019-12690-9.

PubMed ID: 31664022

Diederichs T, Pugh G, Dorey A, Xing Y, Burns JR, Hung Nguyen Q, Tornow M, Tampé R, Howorka S. Synthetic protein-conductive membrane nanopores built with DNA. Nat Commun. 2019 Nov 4;10(1):5018. doi: 10.1038/s41467-019-12639-y.

PubMed ID: 31685824

Wang X, Agasid MT, Baker CA, Aspinwall CA. Surface Modification of Glass/PDMS Microfluidic Valve Assemblies Enhances Valve Electrical Resistance. ACS Appl Mater Interfaces. 2019 Sep 18;11(37):34463-34470. doi: 10.1021/acsami.9b12342. Epub 2019 Sep 9.

PubMed ID: 31496217

Restrepo-Pérez L, Huang G, Bohländer PR, Worp N, Eelkema R, Maglia G, Joo C, Dekker C. Resolving Chemical Modifications to a Single Amino Acid within a Peptide Using a Biological Nanopore. ACS Nano. 2019 Sep 19. doi: 10.1021/acsnano.9b05156. [Epub ahead of print]

PubMed ID: 31536327

Willems K, Ruić D, Biesemans A, Galenkamp NS, Van Dorpe P, Maglia G. Engineering and Modeling the Electrophoretic Trapping of a Single Protein Inside a Nanopore. ACS Nano. 2019 Aug 20. doi: 10.1021/acsnano.8b09137. [Epub ahead of print]

PubMed ID: 31403770

Wang H, Kasianowicz JJ, Robertson JWF, Poster DL, Ettedgui J. A comparison of ion channel current blockades caused by individual poly(ethylene glycol) molecules and polyoxometalate nanoclusters. Eur Phys J E Soft Matter. 2019 Jun 28;42(6):83. doi: 10.1140/epje/i2019-11838-3.

PubMed ID: 31250227

Baxter AM, Wittenberg NJ. Excitation of Fluorescent Lipid Probes Accelerates Supported Lipid Bilayer Formation via Photosensitized Lipid Oxidation. Langmuir. 2019 Sep 3;35(35):11542-11549. doi: 10.1021/acs.langmuir.9b01535. Epub 2019 Aug 22.

PubMed ID: 31411482

Hui Li, Shaoying Wang, Zhouxiang Ji, Congcong Xu, Lyudmila S. Shlyakhtenko, Peixuan Guo. Construction of RNA nanotubes. August 2019;8:1952-1958.

Megalathan A, Cox BD, Wilkerson PD, Kaur A, Sapkota K, Reiner JE, Dhakal S. Single-molecule analysis of i-motif within self-assembled DNA duplexes and nanocircles. Nucleic Acids Res. 2019 Jul 9. pii: gkz565. doi: 10.1093/nar/gkz565. [Epub ahead of print]

PubMed ID: 31287873

Su Z, Ho D, Merrill AR, Lipkowski J. In Situ Electrochemical and PM-IRRAS Studies of Colicin E1 Ion Channels in the Floating Bilayer Lipid Membrane. Langmuir. 2019 Jun 25;35(25):8452-8459. doi: 10.1021/acs.langmuir.9b01251. Epub 2019 Jun 13.

PubMed ID: 31194562

Liu YM, Fang XY, Fang F, Wu ZY. Investigation of hairpin DNA and chelerythrine interaction by a single bio-nanopore sensing interface. Analyst. 2019 Jul 7;144(13):4081-4085. doi: 10.1039/c9an00113a. Epub 2019 Jun 6.

PubMed ID: 31169284

Liu L, Fang Z, Zheng X, Xi D. Nanopore-Based Strategy for Sensing of Copper(II) Ion and Real-Time Monitoring of a Click Reaction. ACS Sens. 2019 May 24;4(5):1323-1328. doi: 10.1021/acssensors.9b00236. Epub 2019 May 10.

PubMed ID: 31050287

Tan S, Zhang L, Yu L, Xu L. Free-Standing Lipid Bilayers Based on Nanopore Array and Ion Channel Formation. J Nanosci Nanotechnol. 2019 Nov 1;19(11):7149-7155. doi: 10.1166/jnn.2019.16674.

PubMed ID: 31039869

Janilson J. S. Júnior, Thereza A. Soares, Laércio Pol-Fachin, Dijanah C. Machado, Victor H. Rusu, Juliana P. Aguiar, and Cláudio G. Rodrigues. Alpha-hemolysin nanopore allows discrimination of the microcystins variants. (Paper) RSC Adv., 2019, 9, 14683-14691. doi: 10.1039/C8RA10384D

Santos HJ, Imai K, Makiuchi T, Tomii K, Horton P, Nozawa A, Okada K, Tozawa Y, Nozaki T. Novel lineage-specific transmembrane β-barrel proteins in the endoplasmic reticulum of Entamoeba histolytica. FEBS J. 2019 May 2. doi: 10.1111/febs.14870. [Epub ahead of print]

PubMed ID: 31070654

Lee MT, Hung WC, Huang HW. Rhombohedral trap for studying molecular oligomerization in membranes: application to daptomycin. Soft Matter. 2019 May 29;15(21):4326-4333. doi: 10.1039/c9sm00323a.

PubMed ID: 31070654

Puthumadathil N, Jayasree P, Santhosh Kumar K, Nampoothiri KM, Bajaj H, Mahendran KR. Detecting the structural assembly pathway of human antimicrobial peptide pores at single-channel level. Biomater Sci. 2019 Jun 5. doi: 10.1039/c9bm00181f. [Epub ahead of print]

PubMed ID: 31165117

Vu T, Borgesi J, Soyring J, D'Alia M, Davidson SL, Shim J. Employing LiCl salt gradient in the wild-type α-hemolysin nanopore to slow down DNA translocation and detect methylated cytosine. Nanoscale. 2019 May 30;11(21):10536-10545. doi: 10.1039/c9nr00502a.

PubMed ID: 31116213

Ji Z, Guo P. Channel from bacterial virus T7 DNA packaging motor for the differentiation of peptides composed of a mixture of acidic and basic amino acids. Biomaterials. 2019 Sep;214:119222. doi: 10.1016/j.biomaterials.2019.119222. Epub 2019 May 21.

PubMed ID: 31158604

Wang K, Preisler SS, Zhang L, Cui Y, Missel JW, Grønberg C, Gotfryd K, Lindahl E, Andersson M, Calloe K, Egea PF, Klaerke DA, Pusch M, Pedersen PA, Zhou ZH, Gourdon P. Structure of the human ClC-1 chloride channel. PLoS Biol. 2019 Apr 25;17(4):e3000218. doi: 10.1371/journal.pbio.3000218. eCollection 2019 Apr.

PubMed ID: 31022181

Larimi MG, Mayse LA, Movileanu L. Interactions of a Polypeptide with a Protein Nanopore Under Crowding Conditions. ACS Nano. 2019 Apr 23;13(4):4469-4477. doi: 10.1021/acsnano.9b00008. Epub 2019 Apr 3.

PubMed ID: 30925041

Noakes MT, Brinkerhoff H, Laszlo AH, Derrington IM, Langford KW, Mount JW, Bowman JL, Baker KS, Doering KM, Tickman BI, Gundlach JH. Increasing the accuracy of nanopore DNA sequencing using a time-varying cross membrane voltage. Nat Biotechnol. 2019 Apr 22. doi: 10.1038/s41587-019-0096-0. [Epub ahead of print]

PubMed ID: 31011178

Khoury ME, Winterstein T, Weber W, Stein V, Schlaak HF, Thiel G. Photolithographic Fabrication of Micro Apertures in Dry Film Polymer Sheets for Channel Recordings in Planar Lipid Bilayers. J Membr Biol. 2019 Mar 12. doi: 10.1007/s00232-019-00062-9. [Epub ahead of print]

PubMed ID: 30863900

Zhao Y, Liu L, Tu Y, Wu HC. Investigating the effect of mono- and multivalent counterions on the conformation of poly(styrenesulfonic acid) by nanopores. Electrophoresis. 2019 Feb 27. doi: 10.1002/elps.201800539. [Epub ahead of print]

PubMed ID: 30811621

Wang J, Fertig N, Ying YL. Real-time monitoring β-lactam/β-lactamase inhibitor (BL/BLI) mixture towards the bacteria porin pathway at single molecule level. Anal Bioanal Chem. 2019 Mar 2. doi: 10.1007/s00216-019-01650-3. [Epub ahead of print]

PubMed ID: 30824965

Golla VK, Sans-Serramitjana E, Pothula KR, Benier L, Bafna JA, Winterhalter M, Kleinekathöfer U. Fosfomycin Permeation through the Outer Membrane Porin OmpF. Biophys J. 2019 Jan 22;116(2):258-269. doi: 10.1016/j.bpj.2018.12.002. Epub 2018 Dec 8.

PubMed ID: 30616836

Coker HLE, Cheetham MR, Kattnig DR, Wang YJ, Garcia-Manyes S, Wallace MI. Controlling Anomalous Diffusion in Lipid Membranes. Biophys J. 2019 Mar 19;116(6):1085-1094. doi: 10.1016/j.bpj.2018.12.024. Epub 2019 Jan 16.

PubMed ID: 30846364

Zhang L, Wang K, Klaerke DA, Calloe K, Lowrey L, Pedersen PA, Gourdon P, Gotfryd K. Purification of Functional Human TRP Channels Recombinantly Produced in Yeast. Cells. 2019 Feb 11;8(2). pii: E148. doi: 10.3390/cells8020148.

PubMed ID: 30754715

Schönrock M, Thiel G, Laube B. Coupling of a viral K+-channel with a glutamate-binding-domain highlights the modular design of ionotropic glutamate-receptors. Commun Biol. 2019 Feb 22;2:75. doi: 10.1038/s42003-019-0320-y. eCollection 2019.

PubMed ID: 30820470

Inada M, Kinoshita M, Sumino A, Oiki S, Matsumori N. A concise method for quantitative analysis of interactions between lipids and membrane proteins. Anal Chim Acta. 2019 Jun 20;1059:103-112. doi: 10.1016/j.aca.2019.01.042. Epub 2019 Feb 1.

PubMed ID: 30876624

Huang G, Voet A, Maglia G. FraC nanopores with adjustable diameter identify the mass of opposite-charge peptides with 44 dalton resolution. Nat Commun. 2019 Feb 19;10(1):835. doi: 10.1038/s41467-019-08761-6.

PubMed ID: 30783102

Krishnan R S, Satheesan R, Puthumadathil N, Kumar KS, Jayasree P, Mahendran KR. Autonomously Assembled Synthetic Transmembrane Peptide Pore. J Am Chem Soc. 2019 Feb 20;141(7):2949-2959. doi: 10.1021/jacs.8b09973. Epub 2019 Feb 12.

PubMed ID: 30702873

Huang G, Voet A, Maglia G. FraC nanopores with adjustable diameter identify the mass of opposite-charge peptides with 44 dalton resolution. Nat Commun. 2019 Feb 19;10(1):835. doi: 10.1038/s41467-019-08761-6.

PubMed ID: 30783102

Krishnan R S, Satheesan R, Puthumadathil N, Kumar KS, Jayasree P, Mahendran KR. Autonomously Assembled Synthetic Transmembrane Peptide Pore. J Am Chem Soc. 2019 Feb 20;141(7):2949-2959. doi: 10.1021/jacs.8b09973. Epub 2019 Feb 12.

PubMed ID: 30702873

Dugger ME, Baker CA. Automated formation of black lipid membranes within a microfluidic device via confocal fluorescence feedback-controlled hydrostatic pressure manipulations. Anal Bioanal Chem. 2019 Jan 7. doi: 10.1007/s00216-018-1550-4. [Epub ahead of print]

PubMed ID: 30617393

Mohid SA, Ghorai A, Ilyas H, Mroue KH, Narayanan G, Sarkar A, Ray SK, Biswas K, Bera AK, Malmsten M, Midya A, Bhunia A. Application of tungsten disulfide quantum dot-conjugated antimicrobial peptides in bio-imaging and antimicrobial therapy. Colloids Surf B Biointerfaces. 2019 Jan 8;176:360-370. doi: 10.1016/j.colsurfb.2019.01.020. [Epub ahead of print]

PubMed ID: 30658284

Bhamidimarri SP, Zahn M, Prajapati JD, Schleberger C, Söderholm S, Hoover J, West J, Kleinekathöfer U, Bumann D, Winterhalter M, van den Berg B. A Multidisciplinary Approach toward Identification of Antibiotic Scaffolds for Acinetobacter baumannii. Structure. 2019 Feb 5;27(2):268-280.e6. doi: 10.1016/j.str.2018.10.021. Epub 2018 Dec 13.

PubMed ID: 30554842

Golla VK, Sans-Serramitjana E, Pothula KR, Benier L, Bafna JA, Winterhalter M, Kleinekathöfer U. Fosfomycin Permeation through the Outer Membrane Porin OmpF. Biophys J. 2019 Jan 22;116(2):258-269. doi: 10.1016/j.bpj.2018.12.002. Epub 2018 Dec 8.

PubMed ID: 30616836

Yang J, Wang Y, Li M, Ying YL, Long YT. Direct Sensing of Single Native RNA with a Single-Biomolecule Interface of Aerolysin Nanopore. Langmuir. 2018 Nov 21. doi: 10.1021/acs.langmuir.8b03264. [Epub ahead of print].

PubMed ID: 30462509

Chengxiang Zhang, Weiyu Zhao , Cong Bian, Xucheng Hou, Binbin Deng, David W. McComb, Xiaofang Chen, and Yizhou Dong. Antibiotic-Derived Lipid Nanoparticles to Treat Intracellular Staphylococcus aureus. ACS Appl. Bio Mater., Article ASAP

Challita EJ, Freeman EC. Hydrogel Microelectrodes for the Rapid, Reliable, and Repeatable Characterization of Lipid Membranes. Langmuir. 2018 Nov 23. doi: 10.1021/acs.langmuir.8b02867. [Epub ahead of print]

PubMed ID: 30468580

Patrick Urban, Stefanie D. Pritzl, David B. Konrad, James A. Frank, Carla Pernpeintner, Christian R. Roeske, Dirk Trauner, and Theobald Lohmueller. Light-Controlled Lipid Interaction and Membrane Organization in Photolipid Bilayer Vesicles. Langmuir, Just Accepted Manuscript. DOI: 10.1021/acs.langmuir.8b03241. Publication Date (Web): October 10, 2018

PubMed ID: 30346771

Sacconi A, Tadini-Buoninsegni F, Tiribilli B, Margheri G. A Comparative Study of Phosphatidylcholine versus Phosphatidylserine-based Solid Supported Membranes for the Preparation of Liposome-Rich Interfaces. Langmuir. 2018 Sep 14. doi: 10.1021/acs.langmuir.8b02397. [Epub ahead of print]

PubMed ID: 30217106

Burden DL, Kim D, Cheng W, Chandler Lawler E, Dreyer DR, Burden LK. Mechanically Enhancing Planar Lipid Bilayers with a Minimal Actin Cortex. Langmuir. 2018 Aug 27. doi: 10.1021/acs.langmuir.8b01847. [Epub ahead of print]

PubMed ID: 30149716

Beltramo PJ, Scheidegger L, Vermant J. Toward Realistic Large-Area Cell Membrane Mimics: Excluding Oil, Controlling Composition, and Including Ion Channels. Langmuir. 2018 May 14. doi: 10.1021/acs.langmuir.8b00837.

PubMed ID: 29715042

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