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MAPCHO-14 | 850338

n-tetradecylphosphocholine

850338P

Powder

1 g
$215.00
5 g
$830.00
10 g
$1520.00
25 g
$3190.00

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Tetradecylphosphocholine is a structural analog of myristoyl lysophosphatidylcholine that is more stable to hydrolytic degradation. The lipid is often used as a detergent for membrane protein solubilization and purification. It has been used as a helper lipid for in vitro and in vivo gene transfer, and it has been shown to have some anticancer activity.
Molecular Formula
C19H42NO4P
Percent Composition
C 60.13%, H 11.15%, N 3.69%, O 16.86%, P 8.16%
Purity
>99%
Stability
1 Years
Storage
-20°C
CAS Number
77733-28-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
379.515
Exact Mass
379.285
CMC
~0.12 mM
Synonyms
TPC
Fos-Choline-14
FOS14
FC-14
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Notes
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File. 
Göbl, C., Dulle, M., Hohlweg, W., Grossauer, J., Falsone, S.F., Glatter, O., Zangger, K. (2010) Influence of phosphocholine alkyl chain length on peptide-micelle interactions and micellar size and shape. J Phys Chem B. 114:4717-24. [PubMed]

Koehler, J., Sulistijo, E.S., Sakakura, M., Kim, H.J., Ellis, C.D., Sanders, C.R. (2010) Lysophospholipid micelles sustain the stability and catalytic activity of diacylglycerol kinase in the absence of lipids.Biochemistry. 49:7089-99. [PubMed]

Vernier, G., Wang, J., Jennings, L.D., Sun, J., Fischer, A., Song, L., Collier, R.J. (2009) Solubilization and characterization of the anthrax toxin pore in detergent micelles. Protein Sci. 18:1882-95. [PubMed]

Cook, B.L., Ernberg, K.E., Chung, H., Zhang, S. (2008)Study of a synthetic human olfactory receptor 17-4: expression and purification from an inducible mammalian cell line. PLoS One. 3:e2920. [PubMed]

Zeisig, R., Ress, A., Fichtner, I., Walther, W. (2003) Lipoplexes with alkylphospholipid as new helper lipid for efficient in vitro and in vivo gene transfer in tumor therapy. Cancer Gene Ther. 10:302-11. [PubMed]