850338 | MAPCHO®-14

n-tetradecylphosphocholine


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1g 850338P-1g 850338P-1g 1 x 1g $243.23
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MAPCHO®-14

MAPCHO®-14

n-tetradecylphosphocholine

Tetradecylphosphocholine is a structural analog of myristoyl lysophosphatidylcholine that is more stable to hydrolytic degradation. The lipid is often used as a detergent for membrane protein solubilization and purification. It has been used as a helper lipid for in vitro and in vivo gene transfer, and it has been shown to have some anticancer activity.
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C19H42NO4P
Percent Composition
C 60.13%, H 11.15%, N 3.69%, O 16.86%, P 8.16%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
77733-28-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
379.515
Exact Mass
379.285
Synonyms
TPCFos-Choline-14FOS14FC-14

Göbl C, Dulle M, Hohlweg W, Grossauer J, Falsone SF, Glatter O, Zangger K. Influence of phosphocholine alkyl chain length on peptide-micelle interactions and micellar size and shape. J Phys Chem B. 2010 Apr 8;114(13):4717-24. doi: 10.1021/jp9114089. PMID: 20225847.

PubMed ID: 20225847

Koehler J, Sulistijo ES, Sakakura M, Kim HJ, Ellis CD, Sanders CR. Lysophospholipid micelles sustain the stability and catalytic activity of diacylglycerol kinase in the absence of lipids. Biochemistry. 2010 Aug 24;49(33):7089-99. doi: 10.1021/bi100575s. PMID: 20666483; PMCID: PMC2923640.

PubMed ID: 20666483

Vernier G, Wang J, Jennings LD, Sun J, Fischer A, Song L, Collier RJ. Solubilization and characterization of the anthrax toxin pore in detergent micelles. Protein Sci. 2009 Sep;18(9):1882-95. doi: 10.1002/pro.199. PMID: 19609933; PMCID: PMC2777363.

PubMed ID: 19609933

Cook BL, Ernberg KE, Chung H, Zhang S. Study of a synthetic human olfactory receptor 17-4: expression and purification from an inducible mammalian cell line. PLoS One. 2008 Aug 6;3(8):e2920. doi: 10.1371/journal.pone.0002920. PMID: 18682799; PMCID: PMC2488374.

PubMed ID: 18682799

Zeisig R, Ress A, Fichtner I, Walther W. Lipoplexes with alkylphospholipid as new helper lipid for efficient in vitro and in vivo gene transfer in tumor therapy. Cancer Gene Ther. 2003 Apr;10(4):302-11. doi: 10.1038/sj.cgt.7700572. PMID: 12679803.

PubMed ID: 12679803