850336 | MAPCHO®-12

n-dodecylphosphocholine


Powder

Size SKU Packaging Price
25g 850336P-25g 850336P-25g 1 x 25g $3,350.00
5g 850336P-5g 850336P-5g 1 x 5g $872.00
1g 850336P-1g 850336P-1g 1 x 1g $226.00
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MAPCHO®-12

MAPCHO®-12

n-dodecylphosphocholine

Dodecylphosphocholine is a structural analog of lauroyl lysophosphatidylcholine that is more stable to hydrolytic degradation. The lipid is often used as a detergent for membrane protein solubilization and purification.
Dodecylphosphocholine has been shown to improve paracellular permeability of hydrophilic compounds by modulating the tight junctions. This may have implications on its use for oral or nasal drug delivery.
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C17H38NO4P
Percent Composition
C 58.10%, H 10.90%, N 3.99%, O 18.21%, P 8.81%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
29557-51-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
351.462
Exact Mass
351.254
Synonyms

DPCFos-Choline-12FOS12FC-12

Palladino, P., Rossi, F., Ragone, R. (2010) Effective critical micellar concentration of a zwitterionic detergent: a fluorimetric study on n-dodecyl phosphocholine. J Fluoresc. 20:191-6. [PubMed] Vasudevan, S.V., Schulz, J., Zhou, C., Cocco, M.J. (2010) Protein folding at the membrane interface, the structure of Nogo-66 requires interactions with a phosphocholine surface. Proc Natl Acad Sci U S A. 107:6847-51. [PubMed] Liang, B., Tamm, L.K. (2007) Structure of outer membrane protein G by solution NMR spectroscopy. Proc Natl Acad Sci U S A. 104:16140-5. [PubMed] Brunecky, R., Lee, S., Rzepecki, P.W., Overduin, M., Prestwich, G.D., Kutateladze, A.G., Kutateladze, T.G. (2005) Investigation of the binding geometry of a peripheral membrane protein. Biochemistry. 44:16064-71. [PubMed] Liu, D.Z., LeCluyse, E.L., Thakker, D.R. (1999) Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers. J Pharm Sci. 88:1161-8. [PubMed]