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MAPCHO®-12 | 850336

n-dodecylphosphocholine

850336P

Powder

850336P-
1g
$226.00
850336P-
5g
$872.00
850336P-
25g
$3350.00

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Dodecylphosphocholine is a structural analog of lauroyl lysophosphatidylcholine that is more stable to hydrolytic degradation. The lipid is often used as a detergent for membrane protein solubilization and purification.
Dodecylphosphocholine has been shown to improve paracellular permeability of hydrophilic compounds by modulating the tight junctions. This may have implications on its use for oral or nasal drug delivery.
Molecular Formula
C17H38NO4P
Percent Composition
C 58.10%, H 10.90%, N 3.99%, O 18.21%, P 8.81%
Purity
>99%
Stability
1 Years
Storage
-20°C
CAS Number
29557-51-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
351.462
Exact Mass
351.254
CMC
1.1 mM
Synonyms
DPC
Fos-Choline-12
FOS12
FC-12
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Notes
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File. 
Palladino, P., Rossi, F., Ragone, R. (2010) Effective critical micellar concentration of a zwitterionic detergent: a fluorimetric study on n-dodecyl phosphocholine. J Fluoresc. 20:191-6. [PubMed]Vasudevan, S.V., Schulz, J., Zhou, C., Cocco, M.J. (2010) Protein folding at the membrane interface, the structure of Nogo-66 requires interactions with a phosphocholine surface. Proc Natl Acad Sci U S A. 107:6847-51. [PubMed]Liang, B., Tamm, L.K. (2007) Structure of outer membrane protein G by solution NMR spectroscopy. Proc Natl Acad Sci U S A. 104:16140-5. [PubMed]Brunecky, R., Lee, S., Rzepecki, P.W., Overduin, M., Prestwich, G.D., Kutateladze, A.G., Kutateladze, T.G. (2005) Investigation of the binding geometry of a peripheral membrane protein. Biochemistry. 44:16064-71. [PubMed]Liu, D.Z., LeCluyse, E.L., Thakker, D.R. (1999) Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers. J Pharm Sci. 88:1161-8. [PubMed]