850312 | DOCPe

2-((2,3-bis(oleoyloxy)propyl)dimethylammonio)ethyl ethyl phosphate


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DOCPe

DOCPe

2-((2,3-bis(oleoyloxy)propyl)dimethylammonio)ethyl ethyl phosphate

Inverse-phosphocholine lipids, a remix of a common phospholipid, contain headgroups with an inverted charge orientation relative to phosphocholine (PC) lipids. The iPC lipid headgroup has a quaternary amine adjacent to the bilayer interface and a phosphate that extends into the aqueous phase.
Therefore iPC lipids afford a unique opportunity to investigate the biophysical and bioactivity-related ramifications of a charge inversion at the bilayer surface.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C45H86NO8P
Percent Composition
C 67.55%, H 10.83%, N 1.75%, O16.00%, P3.87%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
1360461-58-0
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
800.140
Exact Mass
799.609

Wang X, Li X, Wang H, Zhang X, Zhang L, Wang F, Liu J. Charge and Coordination Directed Liposome Fusion onto SiO2 and TiO2 Nanoparticles. Langmuir. 2019 Feb 5;35(5):1672-1681. doi: 10.1021/acs.langmuir.8b02979. Epub 2018 Dec 26.

PubMed ID: 30558422

Wang X, Li X, Wang H, Zhang X, Zhang L, Wang F, Liu J. Charge and Coordination Directed Liposome Fusion onto SiO2 and TiO2 Nanoparticles. Langmuir. 2018 Dec 18. doi: 10.1021/acs.langmuir.8b02979. [Epub ahead of print]

PubMed ID: 30558422

Liu Y, Wang F, Liu J. Headgroup-Inversed Liposomes: Biointerfaces, Supported Bilayers and Applications. Langmuir. 2018 Aug 14;34(32):9337-9348. doi: 10.1021/acs.langmuir.7b04369. Epub 2018 Mar 16.

PubMed ID: 29526108

Wang, F. and J. Liu. (2015). A Stable Lipid/TiO Interface with Headgroup-Inversed Phosphocholine and a Comparison with SiO. J Am Chem Soc. 2015 Sep 16;137(36):11736-42. doi: 10.1021/jacs.5b06642. Epub 2015 Aug 28.

PubMed ID: 26302371

Perttu, E.K., A.G. Kohli, and F.C. Szoka Jr. (2012). Inverse-phosphocholine lipids: a remix of a common phospholipid. J Am Chem Soc 134:4485-8.

PubMed ID: 22364493