850305 | 06:0 PC (DHPC)

1,2-dihexanoyl-sn-glycero-3-phosphocholine


Powder

Size SKU Packaging Price
25mg 850305P-25mg 850305P-25mg 1 x 25mg $80.75
200mg 850305P-200mg 850305P-200mg 1 x 200mg $138.00
500mg 850305P-500mg 850305P-500mg 1 x 500mg $220.00
1g 850305P-1g 850305P-1g 1 x 1g $350.00

Chloroform

Size SKU Packaging Price
25mg 850305C-25mg 850305C-25mg 1 x 25mg 10mg/mL 2.5mL $80.75
200mg 850305C-200mg 850305C-200mg 2 x 100mg 25mg/mL 4mL $138.00
1g 850305C-1g 850305C-1g 2 x 500mg 25mg/mL 20mL $350.00
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06:0 PC (DHPC)

06:0 PC (DHPC)

1,2-dihexanoyl-sn-glycero-3-phosphocholine

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC's. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis. Several of these products are manufactured under the current guidelines of Good Manufacturing Practice and are available for pharmaceutical use. If you have a requirement for a choline derivative not found on our list, please call us: custom synthesis is one of our specialties.

Hygroscopic
Yes
Light Sensitive
No
Molecular Formula
C20H40NO8P
Percent Composition
C 52.97%, H 8.89%, N 3.09%, O 28.22%, P 6.83%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
34506-67-7
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
453.507
Exact Mass
453.249
Synonyms
<p>DHPC</p> <p>1,2-dicaproyl-sn-glycero-3-phosphocholine</p> <p>PC(6:0/6:0)</p>

Nishimura N, Nakayama S, Horiuchi A, Kumoda M, Miyatake T. Reversible Aggregation of Chlorophyll Derivative Induced by Phase Transition of Lipid. Langmuir. 2019 Jun 4;35(22):7242-7248. doi: 10.1021/acs.langmuir.9b00586. Epub 2019 May 16.

PubMed ID: 31063389

Hirano Y, Gao YG, Stephenson DJ, Vu NT, Malinina L, Simanshu DK, Chalfant CE, Patel DJ, Brown RE. Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2α. Elife. 2019 May 3;8. pii: e44760. doi: 10.7554/eLife.44760.

PubMed ID: 31050338

Ip CK, Zhang L, Farzi A, Qi Y, Clarke I, Reed F, Shi YC, Enriquez R, Dayas C, Graham B, Begg D, Brüning JC, Lee NJ, Hernandez-Sanchez D, Gopalasingam G, Koller J, Tasan R, Sperk G, Herzog H. Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions. Cell Metab. 2019 Apr 25. pii: S1550-4131(19)30185-8. doi: 10.1016/j.cmet.2019.04.001. [Epub ahead of print]

PubMed ID: 31031093

Pan J, Dalzini A, Song L. Cholesterol and phosphatidylethanolamine lipids exert opposite effects on membrane modulations caused by the M2 amphipathic helix. Biochim Biophys Acta Biomembr. 2019 Jan;1861(1):201-209. doi: 10.1016/j.bbamem.2018.07.013. Epub 2018 Jul 30

PubMed ID: 30071193

Shogo Taguchi, Keishi Suga, Keita Hayashi, Yukihiro Okamoto, Ho-Sup Jung, Hidemi Nakamura, and Hiroshi Umakoshi. Systematic Characterization of DMPC/DHPC Self-Assemblies and Their Phase Behaviors in Aqueous Solution. 2018 Dec 14. Colloids Interfaces 2018, 2(4), 73; doi: 10.3390/colloids2040073


Taguchi S, Suga K, Hayashi K, Yoshimoto M, Okamoto Y, Nakamura H, Umakoshi H. Aggregation of chlorophyll a induced in self-assembled membranes composed of DMPC and DHPC. Colloids Surf B Biointerfaces. 2019 Mar 1;175:403-408. doi: 10.1016/j.colsurfb.2018.12.008. Epub 2018 Dec 5.

PubMed ID: 30557742

Mortensen HG, Jensen GV, Hansen SK, Vosegaard T, Pedersen JS. Structure of Phospholipid Mixed Micelles (Bicelles) Studied by Small-Angle X-ray Scattering. Langmuir. 2018 Nov 1. doi: 10.1021/acs.langmuir.8b02704. [Epub ahead of print]

PubMed ID: 30383384

Zhang Q, Horst R, Geralt M, Ma X, Hong WX, Finn MG, Stevens RC, Wüthrich K. Microscale NMR screening of new detergents for membrane protein structural biology. J Am Chem Soc. 2008 Jun 11;130(23):7357-63. doi: 10.1021/ja077863d. Epub 2008 May 14.

PubMed ID: 18479092

Miranda C, Booth VK, Morrow MR. Effects of Amphipathic Polypeptides on Membrane Organization Inferred from Studies Using Bicellar Lipid Mixtures. Langmuir. 2018 Sep 20. doi: 10.1021/acs.langmuir.8b02257. [Epub ahead of print]

PubMed ID: 30196696

Kot EF, Arseniev AS, Mineev KS. On the behavior of most widely spread lipids in isotropic bicelles. Langmuir. 2018 Jun 20. doi: 10.1021/acs.langmuir.8b01454. [Epub ahead of print]

PubMed ID: 29924628

Cook, G.A., L.A. Dawson, Y. Tian, and S.J. Opella. (2013). The Three Dimensional Structure and Interaction Studies of HCV p7 in DHPC by Solution NMR. Biochemistry

PubMed ID: 23841474

Liquid Disordered–Liquid Ordered Phase Coexistence in Lipid/Cholesterol Mixtures: A Deuterium 2D NMR Exchange Study Miranda L. Schmidt and James H. Davis* University of Guelph, Department of Physics, 50 Stone Road East, Guelph, Ontario, Canada, N1G 2W1 Langmuir, Article ASAP DOI: 10.1021/acs.langmuir.6b02834 Publication Date (Web): February 6, 2017 Copyright © 2017 American Chemical Society

PubMed ID: 28165749

Kot EF, Goncharuk SA, Arseniev AS, Mineev KS. Phase Transitions in Small Isotropic Bicelles. Langmuir. 2018 Mar 6. doi: 10.1021/acs.langmuir.7b03610.

PubMed ID: 29486112

Bicelles can be integrated into standard crystallization protocols, and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Reference/Protocol