850305 | 06:0 PC (DHPC)


06:0 PC (DHPC)


Size SKU Packaging Price
25mg 850305P-25mg 850305P-25mg 1 x 25mg $108.75
200mg 850305P-200mg 850305P-200mg 1 x 200mg $186.00
500mg 850305P-500mg 850305P-500mg 1 x 500mg $295.00
1g 850305P-1g 850305P-1g 1 x 1g $474.01
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Size SKU Packaging Price
25mg 850305C-25mg 850305C-25mg 1 x 25mg 10mg/mL 2.5mL $108.75 108.75
200mg 850305C-200mg 850305C-200mg 2 x 100mg 25mg/mL 4mL $186.00 186
1g 850305C-1g 850305C-1g 2 x 500mg 25mg/mL 20mL $474.01 474.01
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06:0 PC (DHPC)


The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC's. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis. Several of these products are manufactured under the current guidelines of Good Manufacturing Practice and are available for pharmaceutical use. If you have a requirement for a choline derivative not found on our list, please call us: custom synthesis is one of our specialties.

Light Sensitive
Molecular Formula
Percent Composition
C 52.97%, H 8.89%, N 3.09%, O 28.22%, P 6.83%
1 Years
Storage Temperature
CAS Number
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
Exact Mass
Solubility in Different Solvents
Soluble in ethanol, DMSO, and Chloroform:Methanol:Water (65:25:4) at 5mg/mL

Evans LS, Hussain R, Siligardi G, Williamson PTF. Magnetically aligned membrane mimetics enabling comparable chiroptical and magnetic resonance spectroscopy studies. Biochim Biophys Acta Biomembr. 2020 Sep 1;1862(9):183343. doi: 10.1016/j.bbamem.2020.183343. Epub 2020 May 14. PMID: 32417184.

PubMed ID: 32417184

Piai A, Fu Q, Cai Y, Ghantous F, Xiao T, Shaik MM, Peng H, Rits-Volloch S, Chen W, Seaman MS, Chen B, Chou JJ. Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein. Nat Commun. 2020 May 8;11(1):2317. doi: 10.1038/s41467-020-16165-0. PMID: 32385256; PMCID: PMC7210310.

PubMed ID: 32385256

Zhou X, Dalai P, Sahai N. Semipermeable Mixed Phospholipid-Fatty Acid Membranes Exhibit K+/Na+ Selectivity in the Absence of Proteins. Life (Basel). 2020 Apr 14;10(4):39. doi: 10.3390/life10040039. PMID: 32295197; PMCID: PMC7235748.

PubMed ID: 32295197

Ribić R, Manček-Keber M, Chain F, Sinnaeve D, Martins JC, Jerala R, Tomić S, Fehér K. Targeted Delivery of Adamantylated Peptidoglycan Immunomodulators in Lipid Nanocarriers: NMR Shows That Cargo Fragments Are Available on the Surface. J Phys Chem B. 2020 May 21;124(20):4132-4145. doi: 10.1021/acs.jpcb.0c00029. Epub 2020 May 8. PMID: 32283934.

PubMed ID: 32283934

Li M, Heller WT, Liu CH, Gao CY, Cai Y, Hou Y, Nieh MP. Effects of fluidity and charge density on the morphology of a bicellar mixture - A SANS study. Biochim Biophys Acta Biomembr. 2020 Apr 15;1862(9):183315. doi: 10.1016/j.bbamem.2020.183315. Epub ahead of print. PMID: 32304755.

PubMed ID: 32304755

Yoneda T, Tanimoto Y, Takagi D, Morigaki K. Photosynthetic Model Membranes of Natural Plant Thylakoid Embedded in a Patterned Polymeric Lipid Bilayer. Langmuir. 2020 Jun 2;36(21):5863-5871. doi: 10.1021/acs.langmuir.0c00613. Epub 2020 May 21. PMID: 32390435.

PubMed ID: 32390435

Golubev A, Fatkhullin B, Gabdulkhakov A, Bikmullin A, Nurullina L, Garaeva N, Islamov D, Klochkova E, Klochkov V, Aganov A, Khusainov I, Validov S, Yusupova G, Yusupov M, Usachev K. NMR and crystallographic structural studies of the Elongation factor P from Staphylococcus aureus. Eur Biophys J. 2020 Mar 9. doi: 10.1007/s00249-020-01428-x. Epub ahead of print. PMID: 32152681.

PubMed ID: 32152681

Suga K, Kitagawa K, Taguchi S, Okamoto Y, Umakoshi H. Evaluation of Molecular Ordering in Bicelle Bilayer Membranes Based on Induced Circular Dichroism Spectra. Langmuir. 2020 Mar 20. doi: 10.1021/acs.langmuir.9b03710. Epub ahead of print. PMID: 32163713.

PubMed ID: 32163713

DeLisle CF, Malooley AL, Banerjee I, Lorieau JL. Pro-islet amyloid polypeptide in micelles contains a helical prohormone segment. FEBS J. 2020 Feb 19. doi: 10.1111/febs.15253. Epub ahead of print. PMID: 32077246.

PubMed ID: 32077246

Suga K, Kitagawa K, Taguchi S, Okamoto Y, Umakoshi H. Evaluation of Molecular Ordering in Bicelle Bilayer Membranes Based on Induced Circular Dichroism Spectra. Langmuir. 2020 Mar 12. doi: 10.1021/acs.langmuir.9b03710. Epub ahead of print. PMID: 32163713.

PubMed ID: 32163713

Schmidt ML, Davis JH. 2 H NMR of oriented phospholipid/cholesterol bilayers containing an amphiphilic peptide. Biochim Biophys Acta Biomembr. 2020 Jan 18;1862(5):183196. doi: 10.1016/j.bbamem.2020.183196. Epub ahead of print. PMID: 31958437.

PubMed ID: 31958437

Gao YG, My Le LT, Zhai X, Boldyrev IA, Mishra SK, Tischer A, Murayama T, Nishida A, Molotkovsky JG, Alam A, Brown RE. Measuring Lipid Transfer Protein Activity Using Bicelle-Dilution Model Membranes. Anal Chem. 2020 Feb 18;92(4):3417-3425. doi: 10.1021/acs.analchem.9b05523. Epub 2020 Feb 4. PMID: 31970977.

PubMed ID: 31970977

Mias-Lucquin D, Dos Santos Morais R, Chéron A, Lagarrigue M, Winder SJ, Chenuel T, Pérez J, Appavou MS, Martel A, Alviset G, Le Rumeur E, Combet S, Hubert JF, Delalande O. How the central domain of dystrophin acts to bridge F-actin to sarcolemmal lipids. J Struct Biol. 2020 Jan 1;209(1):107411. doi: 10.1016/j.jsb.2019.107411. Epub 2019 Nov 2. PMID: 31689503.

PubMed ID: 31689503

Ostroff LE, Santini E, Sears R, Deane Z, Kanadia RN, LeDoux JE, Lhakhang T, Tsirigos A, Heguy A, Klann E. Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala. Elife. 2019 Dec 11;8:e51607. doi: 10.7554/eLife.51607. PMID: 31825308; PMCID: PMC6924958.

PubMed ID: 31825308

Leninger M, Sae Her A, Traaseth NJ. Inducing conformational preference of the membrane protein transporter EmrE through conservative mutations. Elife. 2019 Oct 22;8. pii: e48909. doi: 10.7554/eLife.48909.

PubMed ID: 31637997

Szymkowicz L, Lento C, Wilson DJ. Impact of Cardiolipin and Phosphatidylcholine Interactions on the Conformational Ensemble of Cytochrome c. Biochemistry. 2019 Aug 27;58(34):3617-3626. doi: 10.1021/acs.biochem.9b00495. Epub 2019 Aug 12.

PubMed ID: 31380624

Grieco SF, Wang G, Mahapatra A, Lai C, Holmes TC, Xu X. Neuregulin and ErbB expression is regulated by development and sensory experience in mouse visual cortex. J Comp Neurol. 2019 Aug 27. doi: 10.1002/cne.24762. [Epub ahead of print]

PubMed ID: 31454079

Sut TN, Jackman JA, Yoon BK, Park S, Kolahdouzan K, Ma GJ, Zhdanov VP, Cho NJ. Influence of NaCl Concentration on Bicelle-Mediated SLB Formation. Langmuir. 2019 Aug 13;35(32):10658-10666. doi: 10.1021/acs.langmuir.9b01644. Epub 2019 Aug 1.

PubMed ID: 31318563

Crihfield CL, Kristoff CJ, Veltri LM, Penny WM, Holland LA. Semi-permanent cationic coating for protein separations. J Chromatogr A. 2019 Jul 25:460397. doi: 10.1016/j.chroma.2019.460397. [Epub ahead of print]

PubMed ID: 31378525

Sut TN, Jackman JA, Cho NJ. Understanding How Membrane Surface Charge Influences Lipid Bicelle Adsorption onto Oxide Surfaces. Langmuir. 2019 Jun 25;35(25):8436-8444. doi: 10.1021/acs.langmuir.9b00570. Epub 2019 Jun 10.

PubMed ID: 31141663

Nishimura N, Nakayama S, Horiuchi A, Kumoda M, Miyatake T. Reversible Aggregation of Chlorophyll Derivative Induced by Phase Transition of Lipid. Langmuir. 2019 Jun 4;35(22):7242-7248. doi: 10.1021/acs.langmuir.9b00586. Epub 2019 May 16.

PubMed ID: 31063389

Hirano Y, Gao YG, Stephenson DJ, Vu NT, Malinina L, Simanshu DK, Chalfant CE, Patel DJ, Brown RE. Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2α. Elife. 2019 May 3;8. pii: e44760. doi: 10.7554/eLife.44760.

PubMed ID: 31050338

Ip CK, Zhang L, Farzi A, Qi Y, Clarke I, Reed F, Shi YC, Enriquez R, Dayas C, Graham B, Begg D, Brüning JC, Lee NJ, Hernandez-Sanchez D, Gopalasingam G, Koller J, Tasan R, Sperk G, Herzog H. Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions. Cell Metab. 2019 Apr 25. pii: S1550-4131(19)30185-8. doi: 10.1016/j.cmet.2019.04.001. [Epub ahead of print]

PubMed ID: 31031093

Pan J, Dalzini A, Song L. Cholesterol and phosphatidylethanolamine lipids exert opposite effects on membrane modulations caused by the M2 amphipathic helix. Biochim Biophys Acta Biomembr. 2019 Jan;1861(1):201-209. doi: 10.1016/j.bbamem.2018.07.013. Epub 2018 Jul 30

PubMed ID: 30071193

Shogo Taguchi, Keishi Suga, Keita Hayashi, Yukihiro Okamoto, Ho-Sup Jung, Hidemi Nakamura, and Hiroshi Umakoshi. Systematic Characterization of DMPC/DHPC Self-Assemblies and Their Phase Behaviors in Aqueous Solution. 2018 Dec 14. Colloids Interfaces 2018, 2(4), 73; doi: 10.3390/colloids2040073

Taguchi S, Suga K, Hayashi K, Yoshimoto M, Okamoto Y, Nakamura H, Umakoshi H. Aggregation of chlorophyll a induced in self-assembled membranes composed of DMPC and DHPC. Colloids Surf B Biointerfaces. 2019 Mar 1;175:403-408. doi: 10.1016/j.colsurfb.2018.12.008. Epub 2018 Dec 5.

PubMed ID: 30557742

Mortensen HG, Jensen GV, Hansen SK, Vosegaard T, Pedersen JS. Structure of Phospholipid Mixed Micelles (Bicelles) Studied by Small-Angle X-ray Scattering. Langmuir. 2018 Nov 1. doi: 10.1021/acs.langmuir.8b02704. [Epub ahead of print]

PubMed ID: 30383384

Zhang Q, Horst R, Geralt M, Ma X, Hong WX, Finn MG, Stevens RC, Wüthrich K. Microscale NMR screening of new detergents for membrane protein structural biology. J Am Chem Soc. 2008 Jun 11;130(23):7357-63. doi: 10.1021/ja077863d. Epub 2008 May 14.

PubMed ID: 18479092

Miranda C, Booth VK, Morrow MR. Effects of Amphipathic Polypeptides on Membrane Organization Inferred from Studies Using Bicellar Lipid Mixtures. Langmuir. 2018 Sep 20. doi: 10.1021/acs.langmuir.8b02257. [Epub ahead of print]

PubMed ID: 30196696

Kot EF, Arseniev AS, Mineev KS. On the behavior of most widely spread lipids in isotropic bicelles. Langmuir. 2018 Jun 20. doi: 10.1021/acs.langmuir.8b01454. [Epub ahead of print]

PubMed ID: 29924628

Cook, G.A., L.A. Dawson, Y. Tian, and S.J. Opella. (2013). The Three Dimensional Structure and Interaction Studies of HCV p7 in DHPC by Solution NMR. Biochemistry

PubMed ID: 23841474

Liquid Disordered–Liquid Ordered Phase Coexistence in Lipid/Cholesterol Mixtures: A Deuterium 2D NMR Exchange Study Miranda L. Schmidt and James H. Davis* University of Guelph, Department of Physics, 50 Stone Road East, Guelph, Ontario, Canada, N1G 2W1 Langmuir, Article ASAP DOI: 10.1021/acs.langmuir.6b02834 Publication Date (Web): February 6, 2017 Copyright © 2017 American Chemical Society

PubMed ID: 28165749

Kot EF, Goncharuk SA, Arseniev AS, Mineev KS. Phase Transitions in Small Isotropic Bicelles. Langmuir. 2018 Mar 6. doi: 10.1021/acs.langmuir.7b03610.

PubMed ID: 29486112
Bicelle Preparation

Bicelles can be integrated into standard crystallization protocols, and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Reference/Protocol

Certificates of Analysis

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