850200 | Regadenoson

2-[4-[(methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine


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Regadenoson

Regadenoson

2-[4-[(methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine

Regadenoson (Lexiscan) is an A2A adenosine receptor agonist used as a coronary vasodilator in pharmacologic stress testing. Recently, it has been demonstrated that regadenoson can temporarily disrupt the integrity of the blood-brain barrier (BBB) by inhibiting P-glycoprotein function.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C15H18N8O5
Percent Composition
C 46.15%, H 4.65%, N 28.71%, O 20.49%
Purity
>99%
Stability
1 year
Storage Temperature
-20°C
CAS Number
313348-27-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
390.354
Exact Mass
390.140
Synonyms
<p>LexiscanCVT-3146</p>

Cerqueira MD. The future of pharmacologic stress: selective A2A adenosine receptor agonists. Am J Cardiol. 2004 Jul 22;94(2A):33D-40D; discussion 40D-42D. doi: 10.1016/j.amjcard.2004.04.017. PMID: 15261132.

PubMed ID: 15261132

Kim DG, Bynoe MS. A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier. J Clin Invest. 2016 May 2;126(5):1717-33. doi: 10.1172/JCI76207. Epub 2016 Apr 4. PMID: 27043281; PMCID: PMC4855938.

PubMed ID: 27043281