850165 | 18:0-20:4 PI(4,5)P2

1-stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1'-myo-inositol-4',5'-bisphosphate) (ammonium salt)

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100µg 850165P-100ug 850165P-100ug $172.00
500µg 850165P-500ug 850165P-500ug $690.00
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18:0-20:4 PI(4,5)P2

18:0-20:4 PI(4,5)P2

1-stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1'-myo-inositol-4',5'-bisphosphate) (ammonium salt)

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C47H94N3O19P3
Percent Composition
C 51.40%, H 8.63%, N 3.83%, O 27.68%, P 8.46%
Purity
>99%
Stability
3 Months
Storage Temperature
-20°C
CAS Number
799268-59-0
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
1098.179
Exact Mass
1097.569
Synonyms
<p>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-[phosphoinositol-4,5-bisphosphate] (ammonium salt)PIP2[4',5'](18:0/20:4(5Z,8Z,11Z,14Z))</p>

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Wang K, Yang Z, Liu X, Mao K, Nair U, Klionsky DJ. Phosphatidylinositol 4-kinases are required for autophagic membrane trafficking. J Biol Chem. 2012 Nov 2;287(45):37964-72. doi: 10.1074/jbc.M112.371591. Epub 2012 Sep 13. PMID: 22977244; PMCID: PMC3488067.

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Khelashvili G, Galli A, Weinstein H. Phosphatidylinositol 4,5-biphosphate (PIP(2)) lipids regulate the phosphorylation of syntaxin N-terminus by modulating both its position and local structure. Biochemistry. 2012 Oct 2;51(39):7685-98. doi: 10.1021/bi300833z. Epub 2012 Sep 18. PMID: 22950482; PMCID: PMC3462474.

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 PubMed ID: 22722250