850156 | 18:1 PI(3,4,5)P3

1,2-dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) (ammonium salt)


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100µg 850156P-100ug 850156P-100ug $121.00
500µg 850156P-500ug 850156P-500ug $490.00
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18:1 PI(3,4,5)P3

18:1 PI(3,4,5)P3

1,2-dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) (ammonium salt)

Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C45H98N4O22P4
Percent Composition
C 46.15%, H 8.43%, N 4.78%, O 30.05%, P 10.58%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
799268-57-8
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
1171.168
Exact Mass
1170.562
Synonyms
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-[phosphoinositol-3,4,5-trisphosphate] (ammonium salt)
PIP3[3',4',5'](18:1(9Z)/18:1(9Z))

Last MGF, Deshpande S, Dekker C. pH-Controlled Coacervate-Membrane Interactions within Liposomes. ACS Nano. 2020 Apr 28;14(4):4487-4498. doi: 10.1021/acsnano.9b10167. Epub 2020 Apr 7. PMID: 32239914; PMCID: PMC7199211.

PubMed ID: 32239914

Yu CY, Kanehara K. The unfolded protein response modulates a phosphoinositide-binding protein through the IRE1-bZIP60 pathway. Plant Physiol. 2020 Mar 23:pp.01488.2019. doi: 10.1104/pp.19.01488. Epub ahead of print. PMID: 32205450.

PubMed ID: 32205450

Khuong TM, Habets RL, Kuenen S, Witkowska A, Kasprowicz J, Swerts J, Jahn R, van den Bogaart G, Verstreken P. Synaptic PI(3,4,5)P3 is required for Syntaxin1A clustering and neurotransmitter release. Neuron. 2013 Mar 20;77(6):1097-108. doi: 10.1016/j.neuron.2013.01.025. PMID: 23522045.

PubMed ID: 23522045

Jiang RH, Marti M. A PIP Gets the plasmodium protein export pathway going. Cell Host Microbe. 2012 Feb 16;11(2):99-100. doi: 10.1016/j.chom.2012.01.011. PMID: 22341457.

PubMed ID: 22341457

Baskaran S, Ragusa MJ, Boura E, Hurley JH. Two-site recognition of phosphatidylinositol 3-phosphate by PROPPINs in autophagy. Mol Cell. 2012 Aug 10;47(3):339-48. doi: 10.1016/j.molcel.2012.05.027. Epub 2012 Jun 14. PMID: 22704557; PMCID: PMC3595537.

PubMed ID: 22704557

Hammond GR, Fischer MJ, Anderson KE, Holdich J, Koteci A, Balla T, Irvine RF. PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity. Science. 2012 Aug 10;337(6095):727-30. doi: 10.1126/science.1222483. Epub 2012 Jun 21. PMID: 22722250; PMCID: PMC3646512.

PubMed ID: 22722250