850153 | 18:1 PI(3,4)P2

1,2-dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4'-bisphosphate) (ammonium salt)


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100µg 850153P-100μg 850153P-100μg $90.00
500µg 850153P-500μg 850153P-500μg $360.00
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18:1 PI(3,4)P2

18:1 PI(3,4)P2

1,2-dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4'-bisphosphate) (ammonium salt)

Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C45H94N3O19P3
Percent Composition
C 50.32%, H 8.82%, N 3.91%, O 28.30%, P 8.65%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
799268-54-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
1074.158
Exact Mass
1073.569
Synonyms
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-[phosphoinositol-3,4-bisphosphate] (ammonium salt)PIP2[3',4'](18:1(9Z)/18:1(9Z))
Comprehensive and Quantitative Analysis of Polyphosphoinositide Species by Shotgun Lipidomics Revealed Their Alterations in db/db Mouse Brain Chunyan Wang, Juan Pablo Palavicini, Miao Wang, Linyuan Chen, Kui Yang, Peter A. Crawford and Xianlin Han Anal. Chem., Article ASAP DOI: 10.1021/acs.analchem.6b02947 Hammond, G.R., M.J. Fischer, K.E. Anderson, J. Holdich, A. Koteci, T. Balla, and R.F. Irvine. (2012). PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity. Science 337:727-30. The quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P(2)] fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned PM roles apart from PI(4,5)P(2) synthesis. We used a combination of pharmacological and chemical genetic approaches to probe the function of PM PI4P, most of which was not required for the synthesis or functions of PI(4,5)P(2). However, depletion of both lipids was required to prevent PM targeting of proteins that interact with acidic lipids or activation of the transient receptor potential vanilloid 1 cation channel. Therefore, PI4P contributes to the pool of polyanionic lipids that define plasma membrane identity and to some functions previously attributed specifically to PI(4,5)P(2), which may be fulfilled by a more general polyanionic lipid requirement.[PubMed]