850103 | 17:1 Lyso PI

1-(10Z-heptadecenoyl)-2-hydroxy-sn-glycero-3-phospho-(1'-myo-inositol) (ammonium salt)

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500µg 850103P-500ug 850103P-500ug $660.00
100µg 850103P-100ug 850103P-100ug $166.00
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17:1 Lyso PI

17:1 Lyso PI

1-(10Z-heptadecenoyl)-2-hydroxy-sn-glycero-3-phospho-(1'-myo-inositol) (ammonium salt)

Increased circulating levels of L-alpha-lysophosphatidylinositol (LPI) are associated with cancer and LPI is a potent ligand for the G-protein-coupled receptor GPR55.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C26H52NO12P
Percent Composition
C 51.90%, H 8.71%, N 2.33%, O 31.91%, P 5.15%
Purity
>99% LPI; may contain up to 10% of the 2-LPI isomer
Stability
1 Year
Storage Temperature
-20°C
CAS Number
1246353-39-8
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
601.664
Exact Mass
601.323
Synonyms
PI(17:1(10Z)/0:0)
110718

Song JW, Lam SM, Fan X, Cao WJ, Wang SY, Tian H, Chua GH, Zhang C, Meng FP, Xu Z, Fu JL, Huang L, Xia P, Yang T, Zhang S, Li B, Jiang TJ, Wang R, Wang Z, Shi M, Zhang JY, Wang FS, Shui G. Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis. Cell Metab. 2020 Jun 24:S1550-4131(20)30317-X. doi: 10.1016/j.cmet.2020.06.016. Epub ahead of print. PMID: 32610096; PMCID: PMC7311890.

 PubMed ID: 32610096

Yagi T, Kuschner CE, Shoaib M, Choudhary RC, Becker LB, Lee AT, Kim J. Relative Ratios Enhance the Diagnostic Power of Phospholipids in Distinguishing Benign and Cancerous Ovarian Masses. Cancers (Basel). 2019 Dec 26;12(1):E72. doi: 10.3390/cancers12010072. PMID: 31888002.

 PubMed ID: 31888002

Yagi T, Shoaib M, Kuschner C, Nishikimi M, Becker LB, Lee AT, Kim J. Challenges and Inconsistencies in Using Lysophosphatidic Acid as a Biomarker for Ovarian Cancer. Cancers (Basel). 2019 Apr 11;11(4). pii: E520. doi: 10.3390/cancers11040520.

 PubMed ID: 30979045

Zhu X, Gan-Schreier H, Otto AC, Cheng Y, Staffer S, Tuma-Kellner S, Ganzha A, Liebisch G, Chamulitrat W. iPla2β deficiency in mice fed with MCD diet does not correct the defect of phospholipid remodeling but attenuates hepatocellular injury via an inhibition of lipid uptake genes. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):677-687. doi: 10.1016/j.bbalip.2019.02.003. Epub 2019 Feb 5.

 PubMed ID: 30735854

Otto AC, Gan-Schreier H, Zhu X, Tuma-Kellner S, Staffer S, Ganzha A, Liebisch G, Chamulitrat W. Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):662-676. doi: 10.1016/j.bbalip.2019.01.012. Epub 2019 Feb 5.

 PubMed ID: 30735855

Inloes JM, Jing H, Cravatt BF. The Spastic Paraplegia-Associated Phospholipase DDHD1 Is a Primary Brain Phosphatidylinositol Lipase. Biochemistry. 2018 Sep 17. doi: 10.1021/acs.biochem.8b00810. [Epub ahead of print]

 PubMed ID: 30221923