840875 | 18:1 PA

1,2-dioleoyl-sn-glycero-3-phosphate (sodium salt)


Chloroform

Size SKU Packaging Price
25mg 840875C-25mg 840875C-25mg 1 x 25mg 10mg/mL 2.5mL $78.00
200mg 840875C-200mg 840875C-200mg 2 x 100mg 25mg/mL 4mL $234.00
500mg 840875C-500mg 840875C-500mg 5 x 100mg 25mg/mL 4mL $420.00
1g 840875C-1g 840875C-1g 2 x 500mg 25mg/mL 20mL $610.00

Powder

Size SKU Packaging Price
25mg 840875P-25mg 840875P-25mg 1 x 25mg $78.00
200mg 840875P-200mg 840875P-200mg 2 x 100mg $234.00
500mg 840875P-500mg 840875P-500mg 5 x 100mg $420.00
1g 840875P-1g 840875P-1g 1 x 1g $610.00
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18:1 PA

18:1 PA

1,2-dioleoyl-sn-glycero-3-phosphate (sodium salt)

Hygroscopic
Yes
Light Sensitive
No
Molecular Formula
C39H72O8PNa
Percent Composition
C 64.79%, H 10.04%, Na 3.18%, O 17.70%, P 4.28%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
108392-02-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
722.948
Exact Mass
722.486
Synonyms
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate (sodium salt)
DOPA
PA(18:1(9Z)/18:1(9Z))

Yamada H, Hoshino F, Lu Q, Sakane F. Cellular phosphatidic acid sensor, α-synuclein N-terminal domain, detects endogenous phosphatidic acid in macrophagic phagosomes and neuronal growth cones. Biochem Biophys Rep. 2020 May 20;22:100769. doi: 10.1016/j.bbrep.2020.100769. PMID: 32490215; PMCID: PMC7261706.

PubMed ID: 32490215

Rudolphi-Szydło E, Filek M, Dyba B, Miszalski Z, Zembala M. Antioxidative action of polyamines in protection of phospholipid membranes exposed to ozone stress. Acta Biochim Pol. 2020 May 21;67(2):259-262. doi: 10.18388/abp.2020_5230. PMID: 32436672.

PubMed ID: 32436672

Hu Z, Nizzero S, Goel S, Hinkle LE, Wu X, Li C, Ferrari M, Shen H. Molecular targeting of FATP4 transporter for oral delivery of therapeutic peptide. Sci Adv. 2020 Apr 1;6(14):eaba0145. doi: 10.1126/sciadv.aba0145. PMID: 32270048; PMCID: PMC7112756.

PubMed ID: 32270048

Han X, Yang Y, Zhao F, Zhang T, Yu X. An improved protein lipid overlay assay for studying lipid-protein interactions. Plant Methods. 2020 Mar 6;16:33. doi: 10.1186/s13007-020-00578-5. PMID: 32165912; PMCID: PMC7060618.

PubMed ID: 32165912

Hong AW, Meng Z, Plouffe SW, Lin Z, Zhang M, Guan KL. Critical roles of phosphoinositides and NF2 in Hippo pathway regulation. Genes Dev. 2020 Apr 1;34(7-8):511-525. doi: 10.1101/gad.333435.119. Epub 2020 Feb 27. PMID: 32115406; PMCID: PMC7111263.

PubMed ID: 32115406

Peppino Margutti M, Wilke N, Villasuso AL. Influence of Ca2+ on the surface behavior of phosphatidic acid and its mixture with diacylglycerol pyrophosphate at different pHs. Chem Phys Lipids. 2020 May;228:104887. doi: 10.1016/j.chemphyslip.2020.104887. Epub 2020 Feb 3. PMID: 32027867.

PubMed ID: 32027867

Huang Y, Chen Y, Zhou S, Chen L, Wang J, Pei Y, Xu M, Feng J, Jiang T, Liang K, Liu S, Song Q, Jiang G, Gu X, Zhang Q, Gao X, Chen J. Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors. Nat Commun. 2020 Jan 30;11(1):622. doi: 10.1038/s41467-020-14425-7. PMID: 32001695; PMCID: PMC6992734.

PubMed ID: 32001695

Zhu H, Liu Q, Miao L, Musetti S, Huo M, Huang L. Remodeling the fibrotic tumor microenvironment of desmoplastic melanoma to facilitate vaccine immunotherapy. Nanoscale. 2020 Feb 7;12(5):3400-3410. doi: 10.1039/c9nr09610h. Epub 2020 Jan 28. PMID: 31989142.

PubMed ID: 31989142

Huang KW, Hsu FF, Qiu JT, Chern GJ, Lee YA, Chang CC, Huang YT, Sung YC, Chiang CC, Huang RL, Lin CC, Dinh TK, Huang HC, Shih YC, Alson D, Lin CY, Lin YC, Chang PC, Lin SY, Chen Y. Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer. Sci Adv. 2020 Jan 15;6(3):eaax5032. doi: 10.1126/sciadv.aax5032. PMID: 31998834; PMCID: PMC6962042.

PubMed ID: 31998834

Gusti-Ngurah-Putu EP, Huang L, Hsu YC. Effective Combined Photodynamic Therapy with Lipid Platinum Chloride Nanoparticles Therapies of Oral Squamous Carcinoma Tumor Inhibition. J Clin Med. 2019 Dec 2;8(12):2112. doi: 10.3390/jcm8122112. PMID: 31810241; PMCID: PMC6947167.

PubMed ID: 31810241

Huang Y, Xiao Z, Guan Z, Shen Y, Jiang Y, Xu X, Huang Z, Zhao C. A light-triggered self-reinforced nanoagent for targeted chemo-photodynamic therapy of breast cancer bone metastases via ER stress and mitochondria mediated apoptotic pathways. J Control Release. 2019 Dec 25;319:119-134. doi: 10.1016/j.jconrel.2019.12.043. [Epub ahead of print]. PMID: 31883459.

PubMed ID: 31883459

Cao Z, Wang X, Pang Y, Cheng S, Liu J. Biointerfacial self-assembly generates lipid membrane coated bacteria for enhanced oral delivery and treatment. Nat Commun. 2019 Dec 19;10(1):5783. doi: 10.1038/s41467-019-13727-9.

PubMed ID: 31857577

Fantin SM, Parson KF, Niu S, Liu J, Polasky DA, Dixit SM, Ferguson-Miller SM, Ruotolo BT. Collision Induced Unfolding Classifies Ligands Bound to the Integral Membrane Translocator Protein. Anal Chem. 2019 Dec 17;91(24):15469-15476. doi: 10.1021/acs.analchem.9b03208. Epub 2019 Dec 5.

PubMed ID: 31743004

Zhang R, Qiao C, Jia Q, Wang Y, Huang H, Chang W, Wang H, Zhang H, Wang Z. Highly Stable and Long-Circulating Metal-Organic Frameworks Nanoprobes for Sensitive Tumor Detection In Vivo. Adv Healthc Mater. 2019 Jul 31:e1900761. doi: 10.1002/adhm.201900761. [Epub ahead of print]

PubMed ID: 31368240

An Y, Zhu J, Liu F, Deng J, Meng X, Liu G, Wu H, Fan A, Wang Z, Zhao Y. Boosting the Ferroptotic Antitumor Efficacy via Site-Specific Amplification of Tailored Lipid Peroxidation. ACS Appl Mater Interfaces. 2019 Aug 21;11(33):29655-29666. doi: 10.1021/acsami.9b10954. Epub 2019 Aug 8.

PubMed ID: 31359759

Yanjuan Huang, Yali Jiang, Zhanghong Xiao, Yifeng Shen, Liangfeng Huang, Xiaoyu Xu, Gaofei Wei, Congjun Xu, Chunshun Zhao. Three birds with one stone: A ferric pyrophosphate based nanoagent for synergetic NIR-triggered photo/chemodynamic therapy with glutathione depletion. Chemical Engineering Journal. 15 January 2020;380:122369. doi: 10.1016/j.cej.2019.1222369


Khan MW, Zhao P, Khan A, Raza F, Raza SM, Sarfraz M, Chen Y, Li M, Yang T, Ma X, Xiang G. Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity. Int J Nanomedicine. 2019 May 28;14:3753-3771. doi: 10.2147/IJN.S196651. eCollection 2019.

PubMed ID: 31239661

Tang J, Li B, Howard CB, Mahler SM, Thurecht KJ, Wu Y, Huang L, Xu ZP. Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy. Biomaterials. 2019 May 31;216:119232. doi: 10.1016/j.biomaterials.2019.119232. [Epub ahead of print]

PubMed ID: 31195300

Kulig W, Korolainen H, Zatorska M, Kwolek U, Wydro P, Kepczynski M, Róg T. Complex Behavior of Phosphatidylcholine-Phosphatidic Acid Bilayers and Monolayers: Effect of Acyl Chain Unsaturation. Langmuir. 2019 Apr 30;35(17):5944-5956. doi: 10.1021/acs.langmuir.9b00381. Epub 2019 Apr 16.

PubMed ID: 30942590

Zang X, Zhang X, Hu H, Qiao M, Zhao X, Deng Y, Chen D. Targeted Delivery of Zoledronate to Tumor-Associated Macrophages for Cancer Immunotherapy. Mol Pharm. 2019 May 6;16(5):2249-2258. doi: 10.1021/acs.molpharmaceut.9b00261. Epub 2019 Apr 22.

PubMed ID: 30969779

Duan X, Chan C, Han W, Guo N, Weichselbaum RR, Lin W. Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors. Nat Commun. 2019 Apr 23;10(1):1899. doi: 10.1038/s41467-019-09221-x.

PubMed ID: 31015397

Wu Y, Gu W, Li J, Chen C, Xu ZP. Silencing PD-1 and PD-L1 with nanoparticle-delivered small interfering RNA increases cytotoxicity of tumor-infiltrating lymphocytes. Nanomedicine (Lond). 2019 Apr;14(8):955-967. doi: 10.2217/nnm-2018-0237. Epub 2019 Mar 22.

PubMed ID: 3091292

Kulig W, Korolainen H, Zatorska M, Kwolek U, Wydro P, Kepczynski M, Róg T. Complex Behavior of Phosphatidylcholine-Phosphatidic Acid Bilayers and Monolayers: Effect of Acyl Chain Unsaturation. Langmuir. 2019 Apr 16. doi: 10.1021/acs.langmuir.9b00381. [Epub ahead of print]

PubMed ID: 30942590

Gao S, Wan Y, Li W, Huang C. Visualized Networking of Co-Regulated Lipids in Human Blood Based on High-Throughput Screening Data: Implications for Exposure Assessment. Environ Sci Technol. 2019 Mar 5;53(5):2862-2872. doi: 10.1021/acs.est.8b06289. Epub 2019 Feb 21.

PubMed ID: 30739451

Zhang Y, Bush X, Yan B, Chen JA. Gemcitabine nanoparticles promote antitumor immunity against melanoma. Biomaterials. 2019 Jan;189:48-59. doi: 10.1016/j.biomaterials.2018.10.022. Epub 2018 Oct 20.

PubMed ID: 30388589

Amdursky N, Lin Y, Aho N, Groenhof G. Exploring fast proton transfer events associated with lateral proton diffusion on the surface of membranes. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2443-2451. doi: 10.1073/pnas.1812351116. Epub 2019 Jan 24.

PubMed ID: 30679274

Woo J, Jeon YK, Zhang YH, Nam JH, Shin DH, Kim SJ. Am J Physiol Cell Physiol. 2019 Mar 1;316(3):C312-C324. doi: 10.1152/ajpcell.00417.2018. Epub 2018 Dec 21. Triple arginine residues in the proximal C-terminus of TREK K+ channels are critical for biphasic regulation by phosphatidylinositol 4,5-bisphosphate.

PubMed ID: 30576235

McCulloch KM, Yamakawa I, Shifrin DA Jr, McConnell RE, Foegeding NJ, Singh PK, Mao S, Tyska MJ, Iverson TM. An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding. J Biol Chem. 2019 Mar 8;294(10):3454-3463. doi: 10.1074/jbc.RA118.004571. Epub 2019 Jan 4.

PubMed ID: 30610115

Hennessy M, Granade ME, Hassaninasab A, Wang D, Kwiatek JM, Han GS, Harris TE, Carman GM. Casein kinase II-mediated phosphorylation of lipin 1β phosphatidate phosphatase at Ser-285 and Ser-287 regulates its interaction with 14-3-3β protein. J Biol Chem. 2019 Feb 15;294(7):2365-2374. doi: 10.1074/jbc.RA118.007246. Epub 2019 Jan 7.

PubMed ID: 30617183

Hennessy M, Granade ME, Hassaninasab A, Wang D, Kwiatek JM, Han GS, Harris TE, Carman GM. Casein kinase II-mediated phosphorylation of lipin 1β phosphatidate phosphatase at Ser-285 and Ser-287 regulates its interaction with 14-3-3β protein. J Biol Chem. 2019 Feb 15;294(7):2365-2374. doi: 10.1074/jbc.RA118.007246. Epub 2019 Jan 7.

PubMed ID: 30617183

Binte Mustafiz SS, Uyama T, Hussain Z, Kawai K, Tsuboi K, Araki N, Ueda N. The role of intracellular anionic phospholipids in the production of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ε. J Biochem. 2018 Dec 4. doi: 10.1093/jb/mvy104. [Epub ahead of print]

PubMed ID: 30517655

Mizuno H, Kihara Y, Kussrow A, Chen A, Ray M, Rivera R, Bornhop DJ, Chun J. Lysophospholipid G protein-coupled receptor binding parameters as determined by backscattering interferometry. J Lipid Res. 2019 Jan;60(1):212-217. doi: 10.1194/jlr.D089938. Epub 2018 Nov 21.

PubMed ID: 30463988

Gao S, Wan Y, Li W, Huang C. Visualized Networking of Co-Regulated Lipids in Human Blood Based on High-Throughput Screening Data: Implications for Exposure Assessment. Environ Sci Technol. 2019 Feb 21. doi: 10.1021/acs.est.8b06289. [Epub ahead of print

PubMed ID: 30739451

Das M, Shen L, Liu Q, Goodwin TJ, Huang L. Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer. Mol Ther. 2018 Nov 17. pii: S1525-0016(18)30548-3. doi: 10.1016/j.ymthe.2018.11.012. [Epub ahead of print].

PubMed ID: 30545600

Thomas LL, van der Vegt SA, Fromme JC. A Steric Gating Mechanism Dictates the Substrate Specificity of a Rab-GEF. Dev Cell. 2019 Jan 7;48(1):100-114.e9. doi: 10.1016/j.devcel.2018.11.013. Epub 2018 Dec 6.

PubMed ID: 30528786

Feng Y, Chen B, Yu Q, Li L. Identification of Double Bond Position Isomers in Unsaturated Lipids by m-CPBA Epoxidation and Mass Spectrometry Fragmentation. Anal Chem. 2019 Jan 4. doi: 10.1021/acs.analchem.8b04905. [Epub ahead of print]

PubMed ID: 30608661

Chung PJ, Hwang HL, Dasbiswas K, Leong A, Lee KYC. Osmotic shock-triggered assembly of highly-charged, nanoparticle-supported membranes. Langmuir. 2018 Oct 10. doi: 10.1021/acs.langmuir.8b03026. [Epub ahead of print]

PubMed ID: 30303390

Ma L, Li Y, Ma J, Hu S, Li M. Watching Three-Dimensional Movements of Single Membrane Proteins in Lipid Bilayers. Biochemistry. 2018 Apr 12. doi: 10.1021/acs.biochem.8b00253

PubMed ID: 29619828