840046 | Brain PI(4,5)P2

L-α-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt)


Chloroform/Methanol

Size SKU Packaging Price
1mg 840046X-1mg 840046X-1mg 1 x 1mg 1mg/mL 1mL $305.00
5mg 840046X-5mg 840046X-5mg 1 x 5mg 5mg/mL 1mL $1,255.00
10mg 840046X-10mg 840046X-10mg 1 x 10mg 10mg/mL 1mL $2,179.00
25mg 840046X-25mg 840046X-25mg 1 x 25mg 10mg/mL 2.5mL $4,835.00

Powder

Size SKU Packaging Price
1mg 840046P-1mg 840046P-1mg 1 x 1mg $305.00
5mg 840046P-5mg 840046P-5mg 1 x 5mg $1,255.00
10mg 840046P-10mg 840046P-10mg 1 x 10mg $2,179.00
25mg 840046P-25mg 840046P-25mg 1 x 25mg $4,835.00
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Brain PI(4,5)P2

Brain PI(4,5)P2

L-α-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt)

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
Hygroscopic
Yes
Light Sensitive
Yes
Purity
>99%
Stability
3 Months
Storage Temperature
-20°C
CAS Number
383907-42-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
1096.385
Exact Mass
0.000
Synonyms
<p>Brain PI(4,5)P<sub>2</sub></p> cephalin

Bai J, Tucker WC, Chapman ER. PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane. Nat Struct Mol Biol. 2004 Jan;11(1):36-44. Epub 2003 Dec 29.

PubMed ID: 14718921

This Natural Lipid is a mixture and the structure shown above is only representative of one possible structure present in the product. Refer to chart for average fatty acid distribution.
840046FattyAcidDistribution.gif