840046 | Brain PI(4,5)P2

L-α-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt)


Chloroform/Methanol

Size SKU Packaging Price
1mg 840046X-1mg 840046X-1mg 1 x 1mg 1mg/mL 1mL $320.25
5mg 840046X-5mg 840046X-5mg 1 x 5mg 5mg/mL 1mL $1,317.75
10mg 840046X-10mg 840046X-10mg 1 x 10mg 10mg/mL 1mL $2,288.00
25mg 840046X-25mg 840046X-25mg 1 x 25mg 10mg/mL 2.5mL $5,076.75

Powder

Size SKU Packaging Price
1mg 840046P-1mg 840046P-1mg 1 x 1mg $320.25
5mg 840046P-5mg 840046P-5mg 1 x 5mg $1,317.75
10mg 840046P-10mg 840046P-10mg 1 x 10mg $2,288.00
25mg 840046P-25mg 840046P-25mg 1 x 25mg $5,076.75
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Brain PI(4,5)P2

Brain PI(4,5)P2

L-α-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt)

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
Hygroscopic
Yes
Light Sensitive
Yes
Purity
>99%
Stability
3 Months
Storage Temperature
-20°C
CAS Number
383907-42-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
1096.385
Exact Mass
0.000
Synonyms
<p>Brain PI(4,5)P<sub>2</sub></p> cephalin

Kreutzberger AJB, Kiessling V, Stroupe C, Liang B, Preobraschenski J, Ganzella M, Kreutzberger MAB, Nakamoto R, Jahn R, Castle JD, Tamm LK. In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties. Nat Commun. 2019 Aug 29;10(1):3904. doi: 10.1038/s41467-019-11873-8.

PubMed ID: 31467284

Shukla S, Jin R, Robustelli J, Zimmerman ZE, Baumgart T. PIP2 Reshapes Membranes through Asymmetric Desorption. Biophys J. 2019 Sep 3;117(5):962-974. doi: 10.1016/j.bpj.2019.07.047. Epub 2019 Aug 5.

PubMed ID: 31445680

Dai A, Yu L, Wang HW. WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes. Nat Commun. 2019 Aug 16;10(1):3699. doi: 10.1038/s41467-019-11694-9.

PubMed ID: 31420534

Mahajan D, Tie HC, Chen B, Lu L. Dopey1-Mon2 complex binds to dual-lipids and recruits kinesin-1 for membrane trafficking. Nat Commun. 2019 Jul 19;10(1):3218. doi: 10.1038/s41467-019-11056-5.

PubMed ID: 31324769

Valverde D, Yu, Boggavarapu V, Kumar N, Lees JA, Walz T, Reinisch KM, Melia TJ. ATG2 transports lipids to promote autophagosome biogenesis. J Cell Biol. 2019 Apr 5. pii: jcb.201811139. doi: 10.1083/jcb.201811139. [Epub ahead of print]

PubMed ID: 30952800

Zhou H, Wei Z, Wang S, Yao D, Zhang R, Ma C. Structural and Functional Analysis of the CAPS SNARE-Binding Domain Required for SNARE Complex Formation and Exocytosis. Cell Rep. 2019 Mar 19;26(12):3347-3359.e6. doi: 10.1016/j.celrep.2019.02.064.

PubMed ID: 30893606

Tran HT, Anderson LH, Knight JD. Membrane-Binding Cooperativity and Coinsertion by C2AB Tandem Domains of Synaptotagmins 1 and 7. Biophys J. 2019 Mar 19;116(6):1025-1036. doi: 10.1016/j.bpj.2019.01.035. Epub 2019 Feb 5.

PubMed ID: 30795874

Beber A, Taveneau C, Nania M, Tsai FC, Di Cicco A, Bassereau P, Lévy D, Cabral JT, Isambert H, Mangenot S, Bertin A. Membrane reshaping by micrometric curvature sensitive septin filaments. Nat Commun. 2019 Jan 24;10(1):420. doi: 10.1038/s41467-019-08344-5.

PubMed ID: 30679428

Beber A, Taveneau C, Nania M, Tsai FC, Di Cicco A, Bassereau P, Lévy D, Cabral JT, Isambert H, Mangenot S, Bertin A. Membrane reshaping by micrometric curvature sensitive septin filaments. Nat Commun. 2019 Jan 24;10(1):420. doi: 10.1038/s41467-019-08344-5.

PubMed ID: 30679428

Wang S, Li Y, Gong J, Ye S, Yang X, Zhang R, Ma C. Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly. Nat Commun. 2019 Jan 8;10(1):69. doi: 10.1038/s41467-018-08028-6.

PubMed ID: 30622273

Bai J, Tucker WC, Chapman ER. PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane. Nat Struct Mol Biol. 2004 Jan;11(1):36-44. Epub 2003 Dec 29.

PubMed ID: 14718921

This Natural Lipid is a mixture and the structure shown above is only representative of one possible structure present in the product. Refer to chart for average fatty acid distribution.
840046FattyAcidDistribution.gif