840035 | 18:1 PS (DOPS)

1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodium salt)


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Size SKU Packaging Price
10mg 840035P-10mg 840035P-10mg 1 x 10mg $93.90
25mg 840035P-25mg 840035P-25mg 1 x 25mg $131.00
200mg 840035P-200mg 840035P-200mg 2 x 100mg $728.00
500mg 840035P-500mg 840035P-500mg 5 x 100mg $1,255.00

Chloroform

Size SKU Packaging Price
10mg 840035C-10mg 840035C-10mg 1 x 10mg 10mg/mL 1mL $93.90
25mg 840035C-25mg 840035C-25mg 1 x 25mg 10mg/mL 2.5mL $131.00
200mg 840035C-200mg 840035C-200mg 2 x 100mg 25mg/mL 4mL $728.00
500mg 840035C-500mg 840035C-500mg 5 x 100mg 25mg/mL 4mL $1,255.00
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18:1 PS (DOPS)

18:1 PS (DOPS)

1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodium salt)

DOPS is an excellent substitute for the naturally occurring Brain PS. It has similar physical properties and is more stable to oxidation. DOPS has been used, along with DOPC and DOPE, in lipid mixtures to mimic platelet membranes for coagulation studies.

Hygroscopic
Yes
Light Sensitive
No
Molecular Formula
C42H77NO10PNa
Percent Composition
C 62.28%, H 9.58%, N 1.73%, Na 2.84%, O 19.75%, P 3.82%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
90693-88-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
810.025
Exact Mass
809.518
Synonyms
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine (sodium salt)
DOPS
PS(18:1(9Z)/18:1(9Z))

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Rovere M, Powers AE, Jiang H, Pitino JC, Fonseca-Ornelas L, Patel DS, Achille A, Langen R, Varkey J, Bartels T. E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity. J Biol Chem. 2019 Jun 21;294(25):9799-9812. doi: 10.1074/jbc.RA118.006551. Epub 2019 May 2.

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Velasco-Olmo A, Ormaetxea Gisasola J, Martinez Galvez JM, Vera Lillo J, Shnyrova AV. Combining patch-clamping and fluorescence microscopy for quantitative reconstitution of cellular membrane processes with Giant Suspended Bilayers. Sci Rep. 2019 May 10;9(1):7255. doi: 10.1038/s41598-019-43561-4.

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Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. Nature. 2019 May;569(7755):236-240. doi: 10.1038/s41586-019-1167-6. Epub 2019 May 1.

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Maity S, Caillat C, Miguet N, Sulbaran G, Effantin G, Schoehn G, Roos WH, Weissenhorn W. VPS4 triggers constriction and cleavage of ESCRT-III helical filaments. Sci Adv. 2019 Apr 10;5(4):eaau7198. doi: 10.1126/sciadv.aau7198. eCollection 2019 Apr.

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Shuddhodana, Zaher Judeh. Alginate-coating of artemisinin-loaded cochleates results in better control over gastro-intestinal release for effective oral delivery. Journal of Drug Delivery Science and Technology. August 2019;52:27-36. doi: 10.1016/j.jddst.2019.04.020


Bryk AH, Prior SM, Plens K, Konieczynska M, Hohendorff J, Malecki MT, Butenas S, Undas A. Predictors of neutrophil extracellular traps markers in type 2 diabetes mellitus: associations with a prothrombotic state and hypofibrinolysis. Cardiovasc Diabetol. 2019 Apr 16;18(1):49. doi: 10.1186/s12933-019-0850-0.

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Lakomek NA, Yavuz H, Jahn R, Pérez-Lara Á. Structural dynamics and transient lipid binding of synaptobrevin-2 tune SNARE assembly and membrane fusion. Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8699-8708. doi: 10.1073/pnas.1813194116. Epub 2019 Apr 11.

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Çoban Ö, Değim Z, Yılmaz Ş, Altıntaş L, Arsoy T, Sözmen M. Efficacy of targeted liposomes and nanocochleates containing imatinib plus dexketoprofen against fibrosarcoma. Drug Dev Res. 2019 Mar 22. doi: 10.1002/ddr.21530. [Epub ahead of print]

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Gaspar R, Pallbo J, Weininger U, Linse S, Sparr E. Reprint of "Ganglioside lipids accelerate α-synuclein amyloid formation". Biochim Biophys Acta Proteins Proteom. 2019 May;1867(5):508-518. doi: 10.1016/j.bbapap.2019.02.003. Epub 2019 Mar 13.

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Zhang W, Ou X, Wu X. Proteomics profiling of plasma exosomes in epithelial ovarian cancer: A potential role in the coagulation cascade, diagnosis and prognosis. Int J Oncol. 2019 May;54(5):1719-1733. doi: 10.3892/ijo.2019.4742. Epub 2019 Mar 7.

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Höfer CT, Di Lella S, Dahmani I, Jungnick N, Bordag N, Bobone S, Huang Q, Keller S, Herrmann A, Chiantia S. Structural determinants of the interaction between influenza A virus matrix protein M1 and lipid membranes. Biochim Biophys Acta Biomembr. 2019 Mar 20;1861(6):1123-1134. doi: 10.1016/j.bbamem.2019.03.013. [Epub ahead of print]

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Liou AY, Molday LL, Wang J, Andersen JP, Molday RS. Identification and functional analyses of disease-associated P4-ATPase phospholipid flippase variants in red blood cells. J Biol Chem. 2019 Mar 8. pii: jbc.RA118.007270. doi: 10.1074/jbc.RA118.007270. [Epub ahead of print]

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Quade B, Camacho M, Zhao X, Orlando M, Trimbuch T, Xu J, Li W, Nicastro D, Rosenmund C, Rizo J. Membrane bridging by Munc13-1 is crucial for neurotransmitter release. Elife. 2019 Feb 28;8. pii: e42806. doi: 10.7554/eLife.42806.

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Liu Q, Oesterlund EJ, Chi X, Pogmore J, Leber B, Andrews DW. Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2. Elife. 2019 Mar 12;8. pii: e37689. doi: 10.7554/eLife.37689.

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Zhou H, Wei Z, Wang S, Yao D, Zhang R, Ma C. Structural and Functional Analysis of the CAPS SNARE-Binding Domain Required for SNARE Complex Formation and Exocytosis. Cell Rep. 2019 Mar 19;26(12):3347-3359.e6. doi: 10.1016/j.celrep.2019.02.064.

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Ren C, Yuan Q, Braun M, Zhang X, Petri B, Zhang J, Kim D, Guez-Haddad J, Xue W, Pan W, Fan R, Kubes P, Sun Z, Opatowsky Y, Polleux F, Karatekin E, Tang W, Wu D. Leukocyte Cytoskeleton Polarization Is Initiated by Plasma Membrane Curvature from Cell Attachment. Dev Cell. 2019 Mar 23. pii: S1534-5807(19)30146-7. doi: 10.1016/j.devcel.2019.02.023. [Epub ahead of print]

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Lee EY, Zhang C, Di Domizio J, Jin F, Connell W, Hung M, Malkoff N, Veksler V, Gilliet M, Ren P, Wong GCL. Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9. Nat Commun. 2019 Mar 4;10(1):1012. doi: 10.1038/s41467-019-08868-w.

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AhYoung AP, Egea PF. Determining the Lipid-Binding Specificity of SMP Domains: An ERMES Subunit as a Case Study. Methods Mol Biol. 2019;1949:213-235. doi: 10.1007/978-1-4939-9136-5_16.

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Yücel Ç, Altintaş Y, Değim Z, Yılmaz Ş, Arsoy T, Altıntaş L, Çokçalışkan C, Sözmen M. Novel Approach to the Treatment of Diabetes: Embryonic Stem Cell and Insulin-Loaded Liposomes and Nanocochleates. J Nanosci Nanotechnol. 2019 Jul 1;19(7):3706-3719. doi: 10.1166/jnn.2019.16321.

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Shoji A, Takahashi Y, Osato S, Sugawara M. An enzyme-modified capillary as a platform for simultaneous fluorometric detection of d-glucose and l- lactate. J Pharm Biomed Anal. 2019 Jan 30;163:1-8. doi: 10.1016/j.jpba.2018.09.028. Epub 2018 Sep 19.

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Lianhua Shen, Nuriza Ulul Azmi, Xian Wen Tan, Shinsuke Yasuda, Arum Tri Wahyuningsih, Junko Inagaki, Kazuko Kobayashi, Eiji Ando, Takanori Sasaki, Eiji Matsuura. Mutants of β2-glycoprotein I: Their features and potent applications. Best Practice & Research Clinical Rheumatology. 2019 February 26. doi: 10.1016/j.berh.2019.01.007


Tran HT, Anderson LH, Knight JD. Membrane-Binding Cooperativity and Coinsertion by C2AB Tandem Domains of Synaptotagmins 1 and 7. Biophys J. 2019 Mar 19;116(6):1025-1036. doi: 10.1016/j.bpj.2019.01.035. Epub 2019 Feb 5.

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Emilsson G, Röder E, Malekian B, Xiong K, Manzi J, Tsai FC, Cho NJ, Bally M, Dahlin A. Nanoplasmonic Sensor Detects Preferential Binding of IRSp53 to Negative Membrane Curvature. Front Chem. 2019 Feb 4;7:1. doi: 10.3389/fchem.2019.00001. eCollection 2019.

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Zhang X, Xie X, Heckmann BL, Saarinen AM, Gu H, Zechner R, Liu J. Identification of an intrinsic lysophosphatidic acid acyltransferase activity in the lipolytic inhibitor G0/G1 switch gene 2 (G0S2). FASEB J. 2019 Feb 25:fj201802502R. doi: 10.1096/fj.201802502R. [Epub ahead of print]

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Ruiter M, Kádková A, Scheutzow A, Malsam J, Söllner TH, Sørensen JB. An Electrostatic Energy Barrier for SNARE-Dependent Spontaneous and Evoked Synaptic Transmission. Cell Rep. 2019 Feb 26;26(9):2340-2352.e5. doi: 10.1016/j.celrep.2019.01.103.

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Beber A, Taveneau C, Nania M, Tsai FC, Di Cicco A, Bassereau P, Lévy D, Cabral JT, Isambert H, Mangenot S, Bertin A. Membrane reshaping by micrometric curvature sensitive septin filaments. Nat Commun. 2019 Jan 24;10(1):420. doi: 10.1038/s41467-019-08344-5.

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Ciobanasu C, Dragomir I, Apetrei A. The penetrating properties of the tumor homing peptide LyP-1 in model lipid membranes. J Pept Sci. 2019 Mar;25(3):e3145. doi: 10.1002/psc.3145. Epub 2018 Dec 27.

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Misawa N, Fujii S, Kamiya K, Osaki T, Takaku T, Takahashi Y, Takeuchi S. Construction of a Biohybrid Odorant Sensor Using Biological Olfactory Receptors Embedded into Bilayer Lipid Membrane on a Chip. ACS Sens. 2019 Mar 13. doi: 10.1021/acssensors.8b01615. [Epub ahead of print]

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Janas T, Sapoń K, Stowell MH, Janas T. Selection of Membrane RNA Aptamers to Amyloid Beta Peptide: Implications for Exosome-Based Antioxidant Strategies. Int J Mol Sci. 2019 Jan 13;20(2). pii: E299. doi: 10.3390/ijms20020299.

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