810255 | TopFluor® Cholesterol

23-(dipyrrometheneboron difluoride)-24-norcholesterol

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5mg 810255P-5mg 810255P-5mg 1 x 5mg $408.45
10mg 810255P-10mg 810255P-10mg 1 x 10mg $739.20
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TopFluor® Cholesterol

TopFluor® Cholesterol

23-(dipyrrometheneboron difluoride)-24-norcholesterol

Hygroscopic
Yes
Light Sensitive
Yes
Molecular Formula
C36H51BF2N2O
Percent Composition
C 74.99%, H 8.92%, B 1.87%, F 6.59%, N 4.86%, O 2.77%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
878557-19-8
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
576.611
Exact Mass
576.406
Synonyms
<p>Bodipy CholesterolBdp-Chol</p>

Nagano Y, Otake H, Toba T, Kuroda K, Shinkura Y, Tahara N, Tsukiyama Y, Yanaka K, Yamamoto H, Nagasawa A, Onishi H, Sugizaki Y, Takeshige R, Harada A, Murakami K, Kiriyama M, Oshita T, Irino Y, Kawamori H, Ishida T, Toh R, Shinke T, Hirata KI. Impaired Cholesterol-Uptake Capacity of HDL Might Promote Target-Lesion Revascularization by Inducing Neoatherosclerosis After Stent Implantation. J Am Heart Assoc. 2019 May 7;8(9):e011975. doi: 10.1161/JAHA.119.011975.

 PubMed ID: 30995875

Stumpf SK, Berghoff SA, Trevisiol A, Spieth L, Düking T, Schneider LV, Schlaphoff L, Dreha-Kulaczewski S, Bley A, Burfeind D, Kusch K, Mitkovski M, Ruhwedel T, Guder P, Röhse H, Denecke J, Gärtner J, Möbius W, Nave KA, Saher G. Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease. Acta Neuropathol. 2019 Mar 27. doi: 10.1007/s00401-019-01985-2. [Epub ahead of print]

 PubMed ID: 30919030

Cockburn CL, Green RS, Damle SR, Martin RK, Ghahrai NN, Colonne PM, Fullerton MS, Conrad DH, Chalfant CE, Voth DE, Rucks EA, Gilk SD, Carlyon JA. Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens. Life Sci Alliance. 2019 Mar 22;2(2). pii: e201800292. doi: 10.26508/lsa.201800292. Print 2019 Apr.

 PubMed ID: 30902833

Otis JP, Shen MC, Caldwell BA, Reyes Gaido OE, Farber SA. Dietary cholesterol and apolipoprotein A-I are trafficked in endosomes and lysosomes in the live zebrafish intestine. Am J Physiol Gastrointest Liver Physiol. 2019 Mar 1;316(3):G350-G365. doi: 10.1152/ajpgi.00080.2018. Epub 2019 Jan 10.

 PubMed ID: 30629468

Dergunov AD, Litvinov DY, Bazaeva EV, Dmitrieva VG, Nosova EV, Rozhkova AV, Dergunova LV. Relation of High-Density Lipoprotein Charge Heterogeneity, Cholesterol Efflux Capacity, and the Expression of High-Density Lipoprotein-Related Genes in Mononuclear Cells to the HDL-Cholesterol Level. Lipids. 2018 Oct;53(10):979-991. doi: 10.1002/lipd.12104. Epub 2018 Nov 15.

 PubMed ID: 30430582

Nyholm TKM, Jaikishan S, Engberg O, Hautala V, Slotte JP. The Affinity of Sterols for Different Phospholipid Classes and Its Impact on Lateral Segregation. Biophys J. 2019 Jan 22;116(2):296-307. doi: 10.1016/j.bpj.2018.11.3135. Epub 2018 Dec 6.

 PubMed ID: 30583790

Wang M, Liu Z, Zhan W. Janus Liposomes: Gel-Assisted Formation and Bioaffinity-Directed Clustering. Langmuir. 2018 Jun 12. doi: 10.1021/acs.langmuir.8b00798. [Epub ahead of print]

 PubMed ID: 29852065

Crowley, J.T., A.M. Toledo, T.J. LaRocca, J.L. Coleman, E. London, and J.L. Benach. (2013). Lipid exchange between Borrelia burgdorferi and host cells. PLoS Pathog 9:e1003109

 PubMed ID: 23326230

Lund, F.W., M.A. Lomholt, L.M. Solanko, R. Bittman, and D. Wustner. (2012). Two-photon time-lapse microscopy of BODIPY-cholesterol reveals anomalous sterol diffusion in chinese hamster ovary cells. BMC Biophys. 2012 Oct 18;5:20. doi: 10.1186/2046-1682-5-20.

 PubMed ID: 23078907

Littleton, R.M., M. Miller, and J.R. Hove. (2012). Whole plant based treatment of hypercholesterolemia with Crataegus laevigata in a zebrafish model. BMC Complement Altern Med. 2012 Jul 23;12:105. doi: 10.1186/1472-6882-12-105.

 PubMed ID: 22824306

C. Röhrl, C. Meisslitzer-Ruppitsch, R. Bittman, Z. Li, G. Pabst, R. Prassl, W. Strobl, J. Neumüller, A. Ellinger, M. Pavelka, and H. Stangl, “Combined Light and Electron Microscopy using Diaminobenzidine Photooxidation to Monitor Trafficking of Lipids Derived from Lipoprotein Particles,” Curr. Pharm. Biotechnol. 13, 331-340 (2012).

PubMed ID: 21470121

S. Sankaranarayanan, G. Kellner-Weibel, M. de la Llera-Moya, M. C. Phillips, B. F. Asztalos, R. Bittman, and G. H. Rothblat, “A Sensitive Assay for ABCA1-Mediated Cholesterol Efflux Using Bodipy-Cholesterol," J. Lipid Res. 52, 2332-2340 (2011).

 PubMed ID: 21957199

D. Wüstner, L. Solanko, F. W. Lund, O. Garvik, Z. Li, R. Bittman, T. Korte, and A. Herrmann, “Quantitative Assessment of Sterol Traffic in Living Cells by Dual Labeling with Dehydroergosterol and BODIPY-Cholesterol,” Chem. Phys. Lipids 164, 221-235 (2011).

PubMed ID: 21291873

S. Scolari, K. Müller, R. Bittman, A. Herrmann, and P. Müller, “Interaction of Mammalian Seminal Plasma Protein PDC-109 with Cholesterol – Implications for a Putative CRAC Domain,” Biochemistry 49, 9027-9031 (2010).

PubMed ID: 20863067

K. Trajkovic, C. Hsu, S. Chianti, L. Rajendran, D. Wenzel, F. Wieland, P. Schwille, B. Brügger, and M. Simons, "Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes," Science 319, 1244-1247 (2008).

PubMed ID: 18309083

S. Chiantia, J. Ries, G. Chwastek, D. Carrer, Z. Li, R. Bittman, and P. Schwille, “Role of Ceramide in Membrane Protein Organization Investigated by Combined AFM and FCS,” Biochim. Biophys. Acta Biomembranes 1778, 1356-1364 (2008).

PubMed ID: 18346453

B. Y. Baker, R. F. Epand, R. M. Epand, and W. L. Miller, "Cholesterol Binding Does Not predict Activity of the Steroidogenic Acute Regulatory Protein, StAR," Biochemistry 282, 10223-10232 (2007).

PubMed ID: 17301050

J. E. Shaw, R. F. Epand, K. Sinnathamby, Z. Li, R. Bittman, R. M. Epand, and C. M. Yip, “Tracking Peptide-Membrane Interactions: Insights from in situ Coupled Confocal-Atomic Force Microscopy Imaging of NAP-22 Peptide Insertion and Assembly,” J. Struct. Biol. 155, 458-469 (2006).

PubMed ID: 16889981

J. E. Shaw, R. F. Epand, R. M. Epand, Z. Li, R. Bittman, and C. M. Yip, “Correlated Fluorescence-Atomic Force Microscopy of Membrane Domains: Structure of Fluorescence Probes Determines Lipid Localization,” Biophys J. 90, 2170-2178 (2006).

 PubMed ID: 16361347

Z. Li and R. Bittman, “Synthesis and Spectral Properties of Cholesterol- and FTY720-containing Boron Dipyrromethene Dyes,” J. Org. Chem. 72, 8376-8382 (2007).

PubMed ID: 17914846

M. Hölttä-Vuori, R. L. Uronen, J. Repakova, E. Salonen, I. Vattulainen, P. Panula, Z. Li, R. Bittman, and E. Ikonen, “BODIPY-Cholesterol: A New Tool to Visualize Sterol Trafficking in Living Cells and Organisms,” Traffic 9, 1839-1849 (2008).

 PubMed ID: 18647169

D. L. Marks, R. Bittman, and R. E. Pagano, “Use of Bodipy-labeled Sphingolipid and Cholesterol Analogs to Examine Membrane Microdomains in Cells,” Histochem. Cell Biol. 130, 819-832 (2008).

PubMed ID: 18820942

F. S. Ariola, Z. Li, C. Cornejo, R. Bittman, and A. A. Heikal, “Membrane Fluidity and Lipid Order in Ternary Giant Unilamellar Vesicles Using a New Bodipy-Cholesterol Derivative,” Biophys J. 96, 2696-2708 (2009).

PubMed ID: 19348752

Z. Li, E. Mintzer, and R. Bittman, “First Synthesis of Free Cholesterol – BODIPY Conjugates,” J. Org. Chem. 71, 1718-1721 (2006).

PubMed ID: 16468832

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