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TopFluor® PI(4,5)P2 | 810184

1-oleoyl-2-{6-[4-(dipyrrometheneboron difluoride)butanoyl]amino}hexanoyl-sn-glycero-3-phosphoinositol-4,5-bisphosphate (ammonium salt)

810184P

50µg Powder

1 Ea
$488.00

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  • Reference
  • Spectrum
Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
Molecular Formula
C50H92N6O20P3F2
Percent Composition
C 48.47%, H 7.48%, B 0.87%, F 3.07%, N 6.78%, O 25.83%, P 7.50%
Purity
>99%
Stability
6 Months
Storage
-20°C
CAS Number
1246355-57-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
1239.023
Exact Mass
1238.564
Ex/Em
495/503nm
Download
Notes
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File. 
Shi, X., M. Kohram, X. Zhuang, and A.W. Smith. (2016). Interactions and Translational Dynamics of Phosphatidylinositol Bisphosphate (PIP) Lipids in Asymmetric Lipid Bilayers.  Langmuir [PubMed]