810184 | TopFluor® PI(4,5)P2

1-oleoyl-2-{6-[4-(dipyrrometheneboron difluoride)butanoyl]amino}hexanoyl-sn-glycero-3-phosphoinositol-4,5-bisphosphate (ammonium salt)


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50µg 810184P-50µg 810184P-50µg $488.00
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TopFluor® PI(4,5)P<SUB>2</SUB>

TopFluor® PI(4,5)P<SUB>2</SUB>

1-oleoyl-2-{6-[4-(dipyrrometheneboron difluoride)butanoyl]amino}hexanoyl-sn-glycero-3-phosphoinositol-4,5-bisphosphate (ammonium salt)

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C50H92N6O20P3F2
Percent Composition
C 48.47%, H 7.48%, B 0.87%, F 3.07%, N 6.78%, O 25.83%, P 7.50%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
1246355-57-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
1239.023
Exact Mass
1238.564

Shi, X., M. Kohram, X. Zhuang, and A.W. Smith. (2016). Interactions and Translational Dynamics of Phosphatidylinositol Bisphosphate (PIP) Lipids in Asymmetric Lipid Bilayers. Langmuir [PubMed]

PubMed ID: 26829708

Maria J. Sarmento, Ana Coutinho, Aleksander Fedorov, Manuel Prieto, and Fabio Fernandes. Membrane Order Is a Key Regulator of Divalent Cation-Induced Clustering of PI(3,5)P2 and PI(4,5)P2. Langmuir. Article ASAP. [PubMed]

PubMed ID: 28961003
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