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NBD AA | 810106

12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino] arachidonic acid

810106C

Chloroform

1 mg
$1225

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The endocannabinoid pathway influences behavior, lipogenesis, embryologic development, and pathophysiological effects including pain, inflammation, stress, obesity, and non-alcoholic fatty liver disease. Endogenous endocannabinoids including arachidonoylethanolamide (anandamide, AEA) and 2-arachidonoylglycerol (2-AG) are derived from arachidonic acid (AA). Fluorescent NBD-AA and NBD-AEA analogues are direct probes that can be used for visualizing the uptake, intracellular trafficking, and targeting of these molecules by living cells, as well as measuring the binding of endocannabinoids to cytosolic binding proteins. Importantly, direct binding studies show the affinities of the fluorescent analogues are in the same range as the respective unlabeled ligands. Fluorescent endocannabinoid probes are useful for mapping the impact of various treatments, inhibitors, etc on endocannabinoid uptake and distribution in living cells.
Molecular Formula
C26H34 N4O5
Percent Composition
C 64.71%, H 7.10%, N 11.61%, O 16.58%
Purity
>99%
Stability
3 months
Storage
-20°C
Molecular Weight
482.572
Exact Mass
482.253
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Notes
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File.