N-P Tyrosine PA | 800725

N-palmitoyl-tyrosine phosphoric acid (ammonium salt)




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Lysophosphatidic acid (LPA) receptor modulators include N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid. N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid are competitive inhibitors of the LPA receptor in Xenopus oocytes [Neidlinger et al, 2006; Liliom et al, 1996]. However, in mammalian cells, N-palmitoyl-tyrosine phosphoric acid may act as an agonist for the LPA receptor [An et al, 1998]. LPA is a lipid mediator that acts similar to growth factors through G-protein coupled plasma membrane receptors [Neidlinger et al, 2006; Liliom et al, 1996; Bittman et al, 1996; An et al, 1998]. LPA may play a role in platelet aggregation, smooth muscle contraction, vasoactive changes, cytoskeletal reorganization and cell proliferation [Neidlinger et al, 2006].
Product use:
N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acid can be used for cell studies. An et al. dissolved these lipids in 0.1 mL PBS containing 0.1 mg/mL human serum albumin before adding to cells [An et al, 1998]. In X. laevis studies, these LPA inhibitors were dissolved in DMSO at 1 mM and filtered through a 0.45 mM membrane filter before injection [Liliom et al, 1996].
Molecular Formula
Percent Composition
C 56.27%, H 9.07%, N 7.87%, O 20.99%, P 5.80%
1 Years
CAS Number
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
Exact Mass
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Neidlinger, N.A., Larkin, S.K., Bhagat, A., Victorino, G.P., Kuypers, F.A. (2006) Hydrolysis of phosphatidylserine-exposing red blood cells by secretory phospholipase A2 generates lysophosphatidic acid and results in vascular dysfunction. J Biol Chem. 281:775-81. [PubMed]Liliom, K., Bittman, R., Swords, B., Tigyi, G. (1996) N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids are selective competitive antagonists of the lysophosphatidic acid receptors. Mol Pharmacol. 50:616-23. [PubMed]Bittman, R., Swords, B., Liliom, K., Tigyi, G. (1996) Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids. J Lipid Res. 37:391-8. [PubMed]An, S., Bleu, T., Zheng, Y., Goetzl, E.J. (1998) Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. Mol Pharmacol. 54:881-8. [PubMed]