800725 | N-P Tyrosine PA

N-palmitoyl-tyrosine phosphoric acid (ammonium salt)

N-P Tyrosine PA

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1mg 800725P-1mg 800725P-1mg 1 x 1mg $177.62

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N-P Tyrosine PA

N-palmitoyl-tyrosine phosphoric acid (ammonium salt)

Lysophosphatidic acid (LPA) receptor modulators include N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid. N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid are competitive inhibitors of the LPA receptor in Xenopus oocytes [Neidlinger et al, 2006; Liliom et al, 1996]. However, in mammalian cells, N-palmitoyl-tyrosine phosphoric acid may act as an agonist for the LPA receptor [An et al, 1998]. LPA is a lipid mediator that acts similar to growth factors through G-protein coupled plasma membrane receptors [Neidlinger et al, 2006; Liliom et al, 1996; Bittman et al, 1996; An et al, 1998]. LPA may play a role in platelet aggregation, smooth muscle contraction, vasoactive changes, cytoskeletal reorganization and cell proliferation [Neidlinger et al, 2006].
Product use:
N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acid can be used for cell studies. An et al. dissolved these lipids in 0.1 mL PBS containing 0.1 mg/mL human serum albumin before adding to cells [An et al, 1998]. In X. laevis studies, these LPA inhibitors were dissolved in DMSO at 1 mM and filtered through a 0.45 mM membrane filter before injection [Liliom et al, 1996].
Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C25H48N3O7P
Percent Composition
C 56.27%, H 9.07%, N 7.87%, O 20.99%, P 5.80%
Purity
<99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
799268-45-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
533.638
Exact Mass
533.323
References

Neidlinger NA, Larkin SK, Bhagat A, Victorino GP, Kuypers FA. Hydrolysis of phosphatidylserine-exposing red blood cells by secretory phospholipase A2 generates lysophosphatidic acid and results in vascular dysfunction. J Biol Chem. 2006 Jan 13;281(2):775-81. doi: 10.1074/jbc.M505790200. Epub 2005 Nov 8. PMID: 16278219.

PubMed ID: 16278219

Liliom K, Bittman R, Swords B, Tigyi G. N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids are selective competitive antagonists of the lysophosphatidic acid receptors. Mol Pharmacol. 1996 Sep;50(3):616-23. PMID: 8794902.

PubMed ID: 8794902

Bittman R, Swords B, Liliom K, Tigyi G. Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids. J Lipid Res. 1996 Feb;37(2):391-8. PMID: 9026536.

PubMed ID: 9026536

An S, Bleu T, Zheng Y, Goetzl EJ. Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. Mol Pharmacol. 1998 Nov;54(5):881-8. doi: 10.1124/mol.54.5.881. PMID: 9804623.

PubMed ID: 9804623
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