791225 | 14:0 PE-DTPA(Cu)

1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (copper salt)


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14:0 PE-DTPA(Cu)

14:0 PE-DTPA(Cu)

1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (copper salt)

Inclusion of copper (Cu2+) ions in bicelles in the form of a lipid chelate resulted in a 10-fold T1 reduction and 2.7-fold increase in S/N of spectra for static experiments. This improvement would allow 2D experiments on membrane proteins in aligned lipid bilayers that typically take 3 days to be completed in <1.5 days. The technique is particularly beneficial to the study of membrane disrupting/permeating systems (such as antimicrobial peptides, toxins, amyloid peptides, and fusion peptides) whose concentration cannot be increased, as they result in nonlamellar conditions.

Figure kindly provided by Dr. Ayyalusamy Ramamoorthy, Department of Chemistry and Biophysics, University of Michigan.

Hygroscopic
No
Light Sensitive
No
Molecular Formula
C47H94CuN7O17P
Percent Composition
C 50.23%, H 8.43%, Cu 5.65%, N 8.72%, O 24.20%, P 2.76%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
2260795-18-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
1123.806
Exact Mass
1122.574

Yamamoto, K., J. Xu, K.E. Kawulka, J.C. Vederas, and A. Ramamoorthy. (2010). Use of a copper-chelated lipid speeds up NMR measurements from membrane proteins. J Am Chem Soc 132:6929-31 [Abstract]

PubMed ID: 20433169