790981 | 14:0 PE-DTPA (Gd)

1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt)


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14:0 PE-DTPA (Gd)

14:0 PE-DTPA (Gd)

1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt)

Lipid nanoparticles containing DMPE-DTPA(Gd) provide high quality contrast enhanced vascular MRI at 97% reduced dose of Gd and do not rely on renal clearance.
Structure as shown by Cormode, D.P. et al
Cormode, D.P., T. Skajaa, M.M. van Schooneveld, R. Koole, P. Jarzyna, M.E. Lobatto, C. Calcagno, A. Barazza, R.E. Gordon, P. Zanzonico, E.A. Fisher, Z.A. Fayad, and W.J. Mulder. (2008). Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform.  Nano Lett 8:3715-23. [PubMed]
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C47H90GdN6O17P
Percent Composition
C 47.06%, H 7.56%, Gd 13.11%, N 7.01%, O 22.68%, P 2.58%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
827020-81-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
1199.471
Exact Mass
1199.534
Synonyms
<p>1,2-ditetradecanoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt)</p> <p>DMPE-DTPA (Gd)</p>
Barazza, A., C. Blachford, O. Even-Or, V.A. Joaquin, K.C. Briley-Saebo, W. Chen, X.C. Jiang, W.J. Mulder, D.P. Cormode, Z.A. Fayad, and E.A. Fisher. (2013). The Complex Fate in Plasma of Gadolinium Incorporated into High-Density Lipoproteins Used for Magnetic Imaging of Atherosclerotic Plaques. Bioconjug Chem [PubMed] Bui, T., Stevenson, J., Hoekman, J., Zhang, S., Maravilla, K., Ho, R.J. (2010) Novel Gd nanoparticles enhance vascular contrast for high-resolution magnetic resonance imaging. PLoS ONE 5(9). [PubMed] Briley-Saebo, K.C.,Geninatti-Crich, S.,Cormode, D.P.,Barazza, A., Mulder, W.J.M, Chen, W.,Giovenzana, G.B.,Fisher, E.A., Aime, S., Fayad, Z.A. (2009) High-Relaxivity Gadolinium-Modified High-Density Lipoproteins as Magnetic Resonance Imaging Contrast Agents. J. Phys. Chem. B, 113:6283–6289. [ACS Pub] Bertini, I., Bianchini, F., Calorini, L., Colagrande, S., Fragai, M., Franchi, A., Gallo, O., Gavazzi, C., Luchinat, C. (2004)Persistent contrast enhancement by sterically stabilized paramagnetic liposomes in murine melanoma. Magn Reson Med., 52:669-72. [PubMed] Alhaique, F.,Bertini, I.,Fragai, M.,Carafa, M., Luchinat, C.,Parigi, G. (2002) Solvent 1H NMRD study of biotinylated paramagnetic liposomes containing Gd-bis-SDA-DTPA or Gd-DMPE-DTPA. Inorganica Chimica Acta, 331:151-157. [ScienceDirect]