790981 | 14:0 PE-DTPA (Gd)

1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt)


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14:0 PE-DTPA (Gd)

14:0 PE-DTPA (Gd)

1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt)

Lipid nanoparticles containing DMPE-DTPA(Gd) provide high quality contrast enhanced vascular MRI at 97% reduced dose of Gd and do not rely on renal clearance.
Structure as shown by Cormode, D.P. et al
Cormode, D.P., T. Skajaa, M.M. van Schooneveld, R. Koole, P. Jarzyna, M.E. Lobatto, C. Calcagno, A. Barazza, R.E. Gordon, P. Zanzonico, E.A. Fisher, Z.A. Fayad, and W.J. Mulder. (2008). Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform.  Nano Lett 8:3715-23. [PubMed]
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C47H90GdN6O17P
Percent Composition
C 47.06%, H 7.56%, Gd 13.11%, N 7.01%, O 22.68%, P 2.58%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
2260795-83-1
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
1199.471
Exact Mass
1199.534
Synonyms
1,2-ditetradecanoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt)
DMPE-DTPA (Gd)

Barazza A, Blachford C, Even-Or O, Joaquin VA, Briley-Saebo KC, Chen W, Jiang XC, Mulder WJ, Cormode DP, Fayad ZA, Fisher EA. The complex fate in plasma of gadolinium incorporated into high-density lipoproteins used for magnetic imaging of atherosclerotic plaques. Bioconjug Chem. 2013 Jun 19;24(6):1039-48. doi: 10.1021/bc400105j. Epub 2013 May 10. PMID: 23617731; PMCID: PMC3928357.

PubMed ID: 23617731

Bui T, Stevenson J, Hoekman J, Zhang S, Maravilla K, Ho RJ. Novel Gd nanoparticles enhance vascular contrast for high-resolution magnetic resonance imaging. PLoS One. 2010 Sep 30;5(9):e13082. doi: 10.1371/journal.pone.0013082. PMID: 20927340; PMCID: PMC2948015.

PubMed ID: 20927340

Briley-Saebo KC, Geninatti-Crich S, Cormode DP, Barazza A, Mulder WJ, Chen W, Giovenzana GB, Fisher EA, Aime S, Fayad ZA. High-relaxivity gadolinium-modified high-density lipoproteins as magnetic resonance imaging contrast agents. J Phys Chem B. 2009 May 7;113(18):6283-9. doi: 10.1021/jp8108286. PMID: 19361222; PMCID: PMC2688742.

PubMed ID: 19361222

Bertini I, Bianchini F, Calorini L, Colagrande S, Fragai M, Franchi A, Gallo O, Gavazzi C, Luchinat C. Persistent contrast enhancement by sterically stabilized paramagnetic liposomes in murine melanoma. Magn Reson Med. 2004 Sep;52(3):669-72. doi: 10.1002/mrm.20189. PMID: 15334589.

PubMed ID: 15334589

Bicelles can be integrated into standard crystallization protocols, and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Reference/Protocol