790310 | Transfection Reagent I

Transfection Reagent I, contains DOTAP:DOPE (1:1 w/w)


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10mg 790310P-10mg 790310P-10mg 1 x 10mg $303.50
25mg 790310P-25mg 790310P-25mg 1 x 25mg $397.00
200mg 790310P-200mg 790310P-200mg 2 x 100mg $580.00
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Info

Transfection Reagent I

Transfection Reagent I, contains DOTAP:DOPE (1:1 w/w)

DOTAP is one of the most widely used cationic lipids for gene transfection applications. DOTAP is proven to be efficient for in vitro and in vivo transfection applications. Various analogues of TAP are available for structure-activity relationship studies.

Simberg D, Weisman S, Talmon Y, Barenholz Y. DOTAP (and other cationic lipids): chemistry, biophysics, and transfection. Crit Rev Ther Drug Carrier Syst. 2004;21(4):257-317. doi: 10.1615/critrevtherdrugcarriersyst.v21.i4.10. PMID: 15638468.

Data
Hygroscopic
Yes
Light Sensitive
No
Stability
1 Year
Storage Temperature
-20°C
References

Kim BK, Hwang GB, Seu YB, Choi JS, Jin KS, Doh KO. DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes. Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):1996-2001. doi: 10.1016/j.bbamem.2015.06.020. Epub 2015 Jun 23. PMID: 26112463.

PubMed ID: 26112463

Pezzoli D, Kajaste-Rudnitski A, Chiesa R, Candiani G. Lipid-based nanoparticles as nonviral gene delivery vectors. Methods Mol Biol. 2013;1025:269-79. doi: 10.1007/978-1-62703-462-3_21. PMID: 23918345.

PubMed ID: 23918345

Li Y, Bhindi R, Deng ZJ, Morton SW, Hammond PT, Khachigian LM. Inhibition of vein graft stenosis with a c-jun targeting DNAzyme in a cationic liposomal formulation containing 1,2-dioleoyl-3-trimethylammonium propane (DOTAP)/1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE). Int J Cardiol. 2013 Oct 9;168(4):3659-64. doi: 10.1016/j.ijcard.2013.05.092. Epub 2013 Jul 22. PMID: 23886527; PMCID: PMC3951723.

PubMed ID: 23886527
Certificates of Analysis

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