700334 | Glyco-12-oxolithocholanoic acid

5ß-Cholanic acid-12-oxo-3α-ol N-(carboxymethyl)-amide

Glyco-12-oxolithocholanoic acid

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Glyco-12-oxolithocholanoic acid

5ß-Cholanic acid-12-oxo-3α-ol N-(carboxymethyl)-amide

Glyco-12-Oxolithocholanoic Acid is a bile salt (a lipid metabolite), involved in va2rious biological processes.

The compound is a glyco-conjugate, formed of 12-oxolithocholic acid (also known as 12-ketolithocholic acid or 12-oxolithocholanoic acid) - a ketoproduct of lthocholic acid.

Lithocholic acid, on the other hand, is a secondary bile acid, a byproduct of the intestinal microbiota.

Bile acids are physiological steroid molecules with amphipathic nature that prompt absorption, transport, and excretion of fats and sterols in the gastrointestinal tract (GIT) and liver. They exist as anions at physiological pH and require a transport carrier to pass through different enterohepatic membranes. As end products of cholesterol metabolism in the liver, BAs modulate bile flow and secretion and take part in the regulation of a range of key enzymes responsible for cholesterol, glucose, energy, and other BAs homeostasis. They also undergo enterohepatic circuit - after liver and bile duct excretion, they recirculate through the intestines and the portal vein to go back to the liver. Alongside their unique properties of enhancing various metabolic pathways, they have potent toxic effects when accumulate. High BA concentrations cause free radical generation, cell membrane, mitochondria, DNA damage, mutation, and reduced apoptosis.

This way, when present at high levels, lithocholic acid, alongside its derivatives, including the glyco-conjugate Glyco-12-Oxolithocholanoic Acid act as oncometabolites - they stimulate tumor growth and survival. The compounds are associated with different types of cancer - pancreatic, colon, esophageal, and other GIT cancers.

As a glyco-conjugate, 12-Oxolithocholanoic Acid is involved in many other interactions and processes in the organisms. So, it is an important compound, related to different metabolic disorders and diseases.

Avanti Polar Lipids offers a high-quality Glyco-12-Oxolithocholanoic Acid to analyze the structure and activity of glyco-conjugated lipids in relation to human health and medicine.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula

C26H41NO5

Percent Composition

C 69.77%, H 9.23%, N 3.13%, O 17.87%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
80846-41-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
447.62
Exact Mass
447.3
Certificates of Analysis

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