700334 | Glyco-12-oxolithocholanoic acid

5ß-Cholanic acid-12-oxo-3α-ol N-(carboxymethyl)-amide

Glyco-12-oxolithocholanoic acid


Size SKU Packaging Price
5mg 700334P-5mg 700334P-5mg 1 x 5mg $195.00
Request Bulk Pricing


Glyco-12-oxolithocholanoic acid

5ß-Cholanic acid-12-oxo-3α-ol N-(carboxymethyl)-amide

Glyco-12-Oxolithocholanoic Acid is a bile salt (a lipid metabolite), involved in va2rious biological processes.

The compound is a glyco-conjugate, formed of 12-oxolithocholic acid (also known as 12-ketolithocholic acid or 12-oxolithocholanoic acid) - a ketoproduct of lthocholic acid.

Lithocholic acid, on the other hand, is a secondary bile acid, a byproduct of the intestinal microbiota.

Bile acids are physiological steroid molecules with amphipathic nature that prompt absorption, transport, and excretion of fats and sterols in the gastrointestinal tract (GIT) and liver. They exist as anions at physiological pH and require a transport carrier to pass through different enterohepatic membranes. As end products of cholesterol metabolism in the liver, BAs modulate bile flow and secretion and take part in the regulation of a range of key enzymes responsible for cholesterol, glucose, energy, and other BAs homeostasis. They also undergo enterohepatic circuit - after liver and bile duct excretion, they recirculate through the intestines and the portal vein to go back to the liver. Alongside their unique properties of enhancing various metabolic pathways, they have potent toxic effects when accumulate. High BA concentrations cause free radical generation, cell membrane, mitochondria, DNA damage, mutation, and reduced apoptosis.

This way, when present at high levels, lithocholic acid, alongside its derivatives, including the glyco-conjugate Glyco-12-Oxolithocholanoic Acid act as oncometabolites - they stimulate tumor growth and survival. The compounds are associated with different types of cancer - pancreatic, colon, esophageal, and other GIT cancers.

As a glyco-conjugate, 12-Oxolithocholanoic Acid is involved in many other interactions and processes in the organisms. So, it is an important compound, related to different metabolic disorders and diseases.

Avanti Polar Lipids offers a high-quality Glyco-12-Oxolithocholanoic Acid to analyze the structure and activity of glyco-conjugated lipids in relation to human health and medicine.

Light Sensitive
Molecular Formula


Percent Composition

C 69.77%, H 9.23%, N 3.13%, O 17.87%

1 Year
Storage Temperature
CAS Number
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
Exact Mass
Certificates of Analysis

Related Products

Glyco-α-muricholanoic acid Glyco-α-muricholanoic acid Buy Now
Glycoallolithocholanoic acid Glycoallolithocholanoic acid Buy Now
Glyco-ω-muricholanoic acid Glyco-ω-muricholanoic acid Buy Now
Glyco-3ß,5α,6ß -trihydroxycholanoic acid (NPCBA2) Glyco-3ß,5α,6ß -trihydroxycholanoic acid (NPCBA2) Buy Now


Item Price Qty.
${ item.sku }
Base Price: $${ (item.price - (item.options.custompackaging * 4.2 + (item.options.custompackaging > 50 ? 250 : 150))).toFixed(2) }
Custom Packaging: +${ (item.options.custompackaging * 4.2 + (item.options.custompackaging > 50 ? 250 : 150)).toFixed(2) }

Change Custom Packaging
$ ${ item.total.toFixed(2) }
Subtotal: ${ cart.itemSubtotal|money }
${ adjustment.name } ${ adjustment.amountAsCurrency }
Order Total: ${ cart.totalPriceAsCurrency }