700333 | Tauro-12-oxolithocholanoic acid

5ß-Cholanic acid-12-oxo-3α-ol N-(2-sulphoethyl)-amide, sodium salt

Tauro-12-oxolithocholanoic acid

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Tauro-12-oxolithocholanoic acid

5ß-Cholanic acid-12-oxo-3α-ol N-(2-sulphoethyl)-amide, sodium salt

Tauro-12-Oxolithocholanoic Acid is a taurine-conjugated bile acid (BA), synthesized in the liver, forming a bile salt.

The biomolecule is a derivative of 12-ketolithocholic acid (12-oxolithocholanoic acid), formed in the process of taurine conjugation by specific enzymes to create BAs with increased solubility. 12-Oxolithocholanoic acid is a keto-metabolite of lithocholic acid, a secondary BA, and an end product of the enteric bacteria.

Bile acids are amphipathic physiological detergents with steroid molecules and a range of important biological properties. They are formed in the liver as products of cholesterol metabolism, exist as anions, require a transport carrier molecule to pass through different membranes, and undergo an enterohepatic circuit. The main role of BAs is to regulate digestion, absorption, and transport of fats and fat-soluble vitamins in the intestines and liver.

They have also been reported to modulate bile flow, BAs secretion, and metabolism, as well as cholesterol, glucose, and energy homeostasis. Besides their numerous properties, essential to normal occurring biological processes, BAs have pathological effects when present in high concentrations. Accumulated BAs lead to serious cellular damage and disruption of various metabolic pathways.

In that manner, lithocholic acid and its derivatives, including 12-oxolithocholanoic acid and Tauro-12-Oxolithocholanoic acid, tend to promote neoplastic growth, when accumulated.

In addition, it is found that levels of the BA and the conjugate Tauro-12-Oxolithocholanoic Acid are elevated in patients with type 2 diabetes.

The compound Tauro-12-Oxolithocholanoic Acid has many other effects and roles in the human organism, which makes it a reliable source to explore the correlation between specific metabolic pathways and diseases, development of new vaccines, pathological processes such as inflammation or cancer growth, etc.

Get bile salt Tauro-12-Oxolithocholanoic Acid from Avanti Polar Lipids to conduct successful studies on lipids and their derivatives.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula

C26H42NNaO6S

Percent Composition

C 60.09%, H 8.15%, N 2.70%, Na 4.42%, O 18.47%, S 6.7%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
2707415-29-8
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
519.67
Exact Mass
519.26
Certificates of Analysis

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